The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy
Open accessAbstract
Achieving effective treatment of deep-seated tumors is a major challenge for traditional photodynamic therapy (PDT) due to difficulties in delivering light into the subsurface. Thanks to their great tissue penetration, X-rays hold the potential to become an ideal excitation source for activating photosensitizers (PS) that accumulate in deep tumor tissue. Recently, a wide variety of nanoparticles have been developed for this purpose. The nanoparticles are designed as carriers for loading various kinds of PSs and can facilitate the activation process by transferring energy harvested from X-ray irradiation to the loaded PS. In this review, we focus on recent developments of nanoscintillators with high energy transfer efficiency, their rational designs, as well as potential applications in next-generation PDT. Treatment of deep-seated tumors by using radioisotopes as an internal light source will also be discussed.
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Cites
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145
Optical properties of biological tissues: A review
Jacques, S. L. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/11/r37 · Cited by 4,008
Second window for in vivo imaging
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Tada‐Oikawa, S., Oikawa, S., Hirayama, J., Hirakawa, K., & Kawanishi, S. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00600.x · Cited by 80
Cited by
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
Zhou, Z., Song, J., Nie, L., & Chen, X. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00271d · Cited by 2,098
Photosensitizers for Photodynamic Therapy
Lan, M., Zhao, S., Liu, W., Lee, C., Zhang, W., & Wang, P. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900132 · Cited by 1,081
Yang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601
Phototherapy in cancer treatment: strategies and challenges
Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
Qi, J., Chen, C., Zhang, X., Hu, X., Ji, S., Kwok, R. T. K., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2018) · Nature Communications · doi:10.1038/s41467-018-04222-8 · Cited by 350
Metadata
- Authors
- Kamkaew, A., Chen, F., Zhan, Y., Majewski, R. L., & Cai, W.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-04-08
- Volume
- 10
- Issue
- 4
- Pages
- 3918-3935
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2332423385
- Cited by
- 355
- References
- 4
- FWCI
- 34.16
- Type
- journal article
- Language
- en
- Open access
- green
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