The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Multifunctional Two-Dimensional Core–Shell MXene@Gold Nanocomposites for Enhanced Photo–Radio Combined Therapy in the Second Biological Window
Abstract
Multifunctional nanoplatforms with special advantages in the diagnosis and treatment of cancer have been widely explored in nanomedicine. Herein, we synthesize two-dimensional core–shell nanocomposites (Ti 3 C 2 @Au) via a seed-growth method starting from the titanium carbide (Ti 3 C 2 ) nanosheets, a classical type of MXene nanostructure. After growing gold on the surface of Ti 3 C 2 nanosheets, the stability and biocompatibility of the nanocomposites are greatly improved by the thiol modification. Also importantly, the optical absorption in the near-infrared region is enhanced. Utilizing the ability of the high optical absorbance and strong X-ray attenuation, the synthesized Ti 3 C 2 @Au nanocomposites are used for photoacoustic and computed tomography dual-modal imaging. Importantly, the mild photothermal effect of the Ti 3 C 2 @Au nanocomposites could improve the tumor oxygenation, which significantly enhances the radiotherapy. No obvious long-term toxicity of the nanocomposites is found at the injected dose. This work highlights the promise of special properties of MXene-based multifunctional nanostructures for cancer theranostics.
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Cites
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Cited by
Jiang, X., Kuklin, A. V., Baev, A., Ge, Y., Ågren, H., Zhang, H., & Prasad, P. N. (2020) · Physics Reports · doi:10.1016/j.physrep.2019.12.006 · Cited by 914
Liu, G., Zhu, J., Guo, H., Sun, A., Chen, P., Xi, L., Huang, W., Song, X., & Dong, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201910815 · Cited by 394
Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics
Gong, F., Yang, N., Wang, X., Zhao, Q., Chen, Q., Liu, Z., & Cheng, L. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100851 · Cited by 359
Self-citationRecent Advances in Functional 2D MXene‐Based Nanostructures for Next‐Generation Devices
Huang, W., Hu, L., Tang, Y., Xie, Z., & Zhang, H. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202005223 · Cited by 359
Deng, X., Liang, S., Cai, X., Huang, S., Cheng, Z., Shi, Y., Pang, M., Ma, P., & Lin, J. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b01716 · Cited by 319
Metadata
- Authors
- Tang, W., Dong, Z., Zhang, R., Yi, X., Yang, K., Jin, M., Yuan, C., Xiao, Z., Liu, Z., & Cheng, L.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-12-13
- Volume
- 13
- Issue
- 1
- Pages
- 284-294
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2904434219
- Cited by
- 314
- References
- 4
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tang, W., Dong, Z., Zhang, R., Yi, X., Yang, K., Jin, M., Yuan, C., Xiao, Z., Liu, Z., & Cheng, L. (2019). Multifunctional Two-Dimensional Core–Shell MXene@Gold Nanocomposites for Enhanced Photo–Radio Combined Therapy in the Second Biological Window. ACS Nano. https://doi.org/10.1021/acsnano.8b05982
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