Platelet-Mimicking Biotaxis Targeting Vasculature-Disrupted Tumors for Cascade Amplification of Hypoxia-Sensitive Therapy
Abstract
Tumorous vasculature plays key roles in sustaining tumor growth. Vascular disruption is accompanied by internal coagulation along with platelet recruitment and the resulting suppression of oxygen supply. We intend to artificially create this physiological process to establish the mutual feedback between vascular disruption and platelet-mimicking biotaxis for the cascade amplification of hypoxia-dependent therapy. To prove this concept, mesoporous silica nanoparticles are co-loaded with a hypoxia-activated prodrug (HAP) and a vessel-disruptive agent and then coated with platelet membranes. Upon entering into tumors, our nanotherapeutic can disrupt local vasculature for tumor inhibition. This platelet membrane-coated nanoplatform shares the hemorrhage-tropic function with parental platelets and can be persistently recruited by the vasculature-disrupted tumors. In this way, the intratumoral vascular disruption and tumor targeting are biologically interdependent and mutually reinforced. Relying on this mutual feedback, tumorous hypoxia was largely promoted by more than 20-fold, accounting for the effective recovery of the HAP’s cytotoxicity. Consequently, our bioinspired nanodesign has demonstrated highly specific and effective antitumor potency via the biologically driven cooperation among intratumoral vascular disruption, platelet-mimicking biotaxis, cascade hypoxia amplification, and hypoxia-sensitive chemotherapy. This study offers a paradigm of correlating the therapeutic design with the physiologically occurring events to achieve better therapy performance.
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Hypoxia occurs in the majority of solid tumors due to a poor vascular oxygen supply that is not sufficient to meet the needs of rapidly proliferating cancer cells.
“Hypoxia occurs in the majority of solid tumors due to a poor vascular oxygen supply that is not sufficient to meet the needs of rapidly proliferating cancer cells.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [5]
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- Authors
- Zhang, M., Ye, J.-J., Xia, Y., Wang, Z.-Y., Li, C.-X., Wang, X.-S., Yu, W., Song, W., Feng, J., & Zhang, X.-Z.
- Affiliations
- Wuhan University (CN)
- Wuhan University , , ,
- Corresponding author
- Feng, Jun
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-11-12
- Volume
- 13
- Issue
- 12
- Pages
- 14230-14240
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2985710337
- Cited by
- 89
- References
- 65
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 6 · 2023: 9 · 2022: 22 · 2021: 21 · 2020: 8
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2016YFB0700802)
- National Natural Science Foundation of China (21374085, 51533006)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- tumor vasculature disruption, tumor hypoxia, hypoxia-activated prodrug, mesoporous silica nanoparticles, platelet membrane coating
- MeSH terms
- Tumor Hypoxia, Animals, Aorta, Blood Platelets, Cell Adhesion, Epithelial Cells, Female, Mice, Inbred BALB C, Neoplasms, Neovascularization, Pathologic, 3T3 Cells, Biomimetics, Cell Line, Tumor, Mice, Nanoparticles
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