Nanodrug Delivery Systems Modulate Tumor Vessels to Increase the Enhanced Permeability and Retention Effect
Open accessAbstract
The use of nanomedicine for antitumor therapy has been extensively investigated for a long time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently regarded as an effective way to bring drugs to tumors, especially macromolecular drugs and drug-loaded pharmaceutical nanocarriers. However, a disordered vessel network, and occluded or embolized tumor blood vessels seriously limit the EPR effect. To augment the EPR effect and improve curative effects, in this review, we focused on the perspective of tumor blood vessels, and analyzed the relationship among abnormal angiogenesis, abnormal vascular structure, irregular blood flow, extensive permeability of tumor vessels, and the EPR effect. In this commentary, nanoparticles including liposomes, micelles, and polymers extravasate through the tumor vasculature, which are based on modulating tumor vessels, to increase the EPR effect, thereby increasing their therapeutic effect.
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Many clinical cancers such as late-stage and refractory tumors are associated with poor blood flow due to coagulation and thrombi formation, exhibiting poor EPR effect.
“However, many clinical cancers such as late-stage tumors and refractory tumors are associated with poor blood flow due to the coagulation and thrombi formation exhibiting poor EPR effect [7,8,9,10,11,12].”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [11]
Sections 2.1 and 2.2 (pages not provided) explain that abnormal tumor vessels can impair blood flow and interfere with the EPR effect. They attribute poor perfusion to vascular abnormalities and solid stress, not to coagulation or thrombi formation, and do not establish the claim specifically for late-stage or refractory tumors. (LLM, conf=0.87)
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2 retracted
Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy
Kunjachan, S., Detappe, A., Kumar, R., Ireland, T. J., Cameron, L., Biancur, D. E., Motto‐Ros, V., Sancey, L., Sridhar, S., Makrigiorgos, G. M., et al. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b03073 · Cited by 153 · see citing works
RetractedBharali, D. J., Yalçın, M., Davis, P. J., & Mousa, S. A. (2013) · Nanomedicine · doi:10.2217/nnm.12.200 · Cited by 69 · see citing works
RetractedBray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109 · see citing works
Siegel, R. L., Miller, K. D., & Jemal, A. (2020) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21590 · Cited by 20,444 · see citing works
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399 · see citing works
Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,771 · see citing works
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
Jain, R. K. (2005) · Science · doi:10.1126/science.1104819 · Cited by 5,527 · cited 3× · see citing works
“In addition, the proliferating cancer cells in the center of the tumor tissue will form excessive pressure and compress the blood vessels and lymphatic vessels, leading to vascular collapse [88,94,95].”
BackgroundMolecular mechanisms and clinical applications of angiogenesis
Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467 · see citing works
Doxil® — The first FDA-approved nano-drug: Lessons learned
Barenholz, Y. (. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.020 · Cited by 4,792 · see citing works
What Is the Evidence That Tumors Are Angiogenesis Dependent?
Folkman, J. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.1.4 · Cited by 4,509 · see citing works
Angiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,258 · see citing works
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981 · see citing works
Tumour heterogeneity and resistance to cancer therapies
Dagogo-Jack, I., & Shaw, A. T. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.166 · Cited by 3,846 · see citing works
Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759 · see citing works
Fang, J. Q., Nakamura, H., & Maeda, H. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.04.009 · Cited by 3,573 · see citing works
Delivering nanomedicine to solid tumors
Jain, R. K., & Stylianopoulos, T. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.139 · Cited by 3,196 · see citing works
Angiogenesis as a therapeutic target
Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653 · see citing works
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
Ferrara, N., Hillan, K. J., Gerber, H.-P., & Novotny, W. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1381 · Cited by 2,625 · see citing works
Molecular regulation of vessel maturation
Jain, R. K. (2003) · Nature Medicine · doi:10.1038/nm0603-685 · Cited by 2,515 · see citing works
Role of platelet-derived growth factors in physiology and medicinePreprint
Andræ, J., Gallini, R., & Betsholtz, C. (2008) · Genes & Development · doi:10.1101/gad.1653708 · Cited by 2,444 · see citing works
Maeda, H., Nakamura, H., & Fang, J. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.002 · Cited by 2,376 · see citing works
Drug Resistance and the Solid Tumor Microenvironment
Tredan, O., Galmarini, C. M., Patel, K., & Tannock, I. F. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm135 · Cited by 2,116 · cited 1× · see citing works
“Unlike normal blood vessels, tumor blood vessels with abnormal structure and function impede the delivery of adequate and effective oxygen, as well as therapeutic drugs to cancer cells [88,89].”
BackgroundEnhancing cancer immunotherapy using antiangiogenics: opportunities and challenges
Fukumura, D., Kloepper, J., Amoozgar, Z., Duda, D. G., & Jain, R. K. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2018.29 · Cited by 2,027 · see citing works
Ornitz, D. M., & Itoh, N. (2001) · Genome biology · doi:10.1186/gb-2001-2-3-reviews3005 · Cited by 1,985 · see citing works
Millauer, B., Wizigmann-Voos, S., Schnürch, H., Martínez, R., Møller, N. P. H., Risau, W., & Ullrich, A. (1993) · Cell · doi:10.1016/0092-8674(93)90573-9 · Cited by 1,925 · see citing works
The entry of nanoparticles into solid tumours
Sindhwani, S., Syed, A. M., Ngai, J., Kingston, B. R., Maiorino, L., Rothschild, J., MacMillan, P., Zhang, Y., Rajesh, N. U., Hoang, T., et al. (2020) · Nature Materials · doi:10.1038/s41563-019-0566-2 · Cited by 1,732 · see citing works
The therapeutic potential of carbon monoxide
Motterlini, R., & Otterbein, L. E. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3228 · Cited by 1,643 · see citing works
Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia
Jain, R. K. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.006 · Cited by 1,589 · see citing works
Prabhakar, U., Maeda, H., Jain, R. K., Sevick-Muraca, E. M., Zamboni, W. C., Farokhzad, O. C., Barry, S. T., Gabizón, A., Grodzinski, P. A., & Blakey, D. C. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4561 · Cited by 1,493 · see citing works
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
Facciabene, A., Peng, X., Hagemann, I. S., Balint, K., Barchetti, A., Wang, L.-P., Gimotty, P. A., Gilks, C. B., Lal, P., Zhang, L., et al. (2011) · Nature · doi:10.1038/nature10169 · Cited by 1,376 · see citing works
Li, A., Dubey, S., Varney, M. L., Davé, B. J., & Singh, R. K. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3369 · Cited by 1,324 · see citing works
Danhier, F. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.11.015 · Cited by 1,288 · see citing works
Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers
Jain, R. K. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.46.3653 · Cited by 1,248 · see citing works
Challenges and strategies in anti-cancer nanomedicine development: An industry perspective
Hare, J. I., Lammers, T., Ashford, M. B., Puri, S., Storm, G., & Barry, S. T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.025 · Cited by 1,246 · see citing works
Papapetropoulos, A., García‐Cardeña, G., Madri, J. A., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119868 · Cited by 1,192 · see citing works
Tong, R. T., Boucher, Y., Kozin, S. V., Winkler, F., Hicklin, D. J., & Jain, R. K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0074 · Cited by 1,189 · see citing works
Role of extracellular matrix assembly in interstitial transport in solid tumors.
Netti, P. A., Berk, D. A., Swartz, M. A., Grodzinsky, A. J., & Jain, R. K. (2000) · PubMed · Cited by 1,165 · see citing works
Du, R., Lu, K. V., Petritsch, C. K., Liu, P., Ganß, R., Passegue, E. A., Song, H., VandenBerg, S. R., Johnson, R. S., Werb, Z., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.034 · Cited by 1,131 · see citing works
Pharmacological and Clinical Aspects of Heme Oxygenase
Abraham, N. G., & Kappas, A. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07104 · Cited by 1,115 · see citing works
Chauhan, V. P., Stylianopoulos, T., Martin, J. D., Popović, Z., Chen, O., Kamoun, W. S., Bawendi, M. G., Fukumura, D., & Jain, R. K. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.45 · Cited by 1,101 · see citing works
Chauhan, V. P., Martin, J. D., Liu, H., Lacorre, D. A., Jain, S. R., Kozin, S. V., Stylianopoulos, T., Mousa, A. S., Han, X., Adstamongkonkul, P., et al. (2013) · Nature Communications · doi:10.1038/ncomms3516 · Cited by 1,031 · see citing works
Prospects for combining targeted and conventional cancer therapy with immunotherapy
Gotwals, P. J., Cameron, S. B., Cipolletta, D., Cremasco, V., Crystal, A., Hewes, B., Mueller, B., Quaratino, S., Sabatos-Peyton, C. A., Petruzzelli, L., et al. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.17 · Cited by 948 · see citing works
Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system
Sengupta, S., Eavarone, D. A., Capila, I., Zhao, G., Watson, N., Kiziltepe, T., & Sasisekharan, R. (2005) · Nature · doi:10.1038/nature03794 · Cited by 946 · see citing works
Seghezzi, G., Patel, S., Ren, C. J., Gualandris, A., Pintucci, G., Robbins, E., Shapiro, R., Galloway, A., Rifkin, D., & Mignatti, P. (1998) · Journal of Cell Biology · doi:10.1083/jcb.141.7.1659 · Cited by 887 · see citing works
Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.
Itoh, T., Tanioka, M., Yoshida, H., Yoshioka, T., Nishimoto, H., & Itohara, S. (1998) · PubMed · Cited by 875 · see citing works
Cancer cells compress intratumour vessels
Padera, T. P., Stoll, B. R., Tooredman, J. B., Capen, D., Tomaso, E. D., & Jain, R. K. (2004) · Nature · doi:10.1038/427695a · Cited by 857 · see citing works
Kalyane, D., Raval, N., Maheshwari, R., Tambe, V., Kalia, K., & Tekade, R. K. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.01.066 · Cited by 851 · see citing works
Palucka, A. K., & Coussens, L. M. (2016) · Cell · doi:10.1016/j.cell.2016.01.049 · Cited by 843 · see citing works
Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion
Wu, Y., Deng, J., Rychahou, P. G., Qiu, S., Evers, B. M., & Zhou, B. P. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.016 · Cited by 797 · see citing works
Transport of drugs from blood vessels to tumour tissue
Dewhirst, M. W., & Secomb, T. W. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.93 · Cited by 749 · see citing works
Rolny, C., Mazzone, M., Tugues, S., Laoui, D., Johansson, I., Coulon, C., Squadrito, M. L., Segura, I., Li, X., Knevels, E., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.11.009 · Cited by 695 · cited 3× · see citing works
“Thus far, 28 proangiogenic factors/genes have been found to mediate tumor angiogenesis [76,77], including the fibroblast growth factor (FGF), hypoxiainducible factor (HIF), platelet-derived growth factor-B (PDGF-B), tumor necrosis factor-α (TNF-α), chemokines, integrins, and transforming growth factor-β (TGF-β), as we…”
BackgroundLee, C. G., Heijn, M., di Tomaso, E., Griffon, G., Ancukiewicz, M., Koike, C., Park, K. R., Ferrara, N., Jain, R. K., Suit, H. D., et al. (2000) · PubMed · Cited by 674 · see citing works
Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy
Huang, Y., Goel, S., Duda, D. G., Fukumura, D., & Jain, R. K. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4354 · Cited by 669 · see citing works
Why are tumour blood vessels abnormal and why is it important to know?
Nagy, J. A., Chang, S.-H., Dvorak, A. M., & Dvorak, H. F. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6604929 · Cited by 611 · see citing works
Siemann, D. W. (2011) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2010.05.001 · Cited by 611 · see citing works
Vascular endothelial growth factor (VEGF) signaling in tumor progression
Roskoski, R. J. (2007) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.01.006 · Cited by 602 · see citing works
Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies
Chauhan, V. P., Stylianopoulos, T., Boucher, Y., & Jain, R. K. (2011) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-061010-114300 · Cited by 597 · see citing works
Dynamics of endothelial cell behavior in sprouting angiogenesis
Eilken, H. M., & Adams, R. H. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.08.010 · Cited by 566 · see citing works
Nagy, J. A., Vasile, E., Feng, D., Sundberg, C., Brown, L. F., Detmar, M. J., Lawitts, J. A., Benjamin, L. E., Tan, X., Manseau, E. J., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021244 · Cited by 559 · see citing works
A reevaluation of integrins as regulators of angiogenesis
Hynes, R. O. (2002) · Nature Medicine · doi:10.1038/nm0902-918 · Cited by 546 · see citing works
Maeda, H., Fang, J. Q., Inutsuka, T., & Kitamoto, Y. (2003) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00271-0 · Cited by 537 · see citing works
Cooke, V. G., LeBleu, V. S., Keskin, D., Khan, Z., O'Connell, J. T., Teng, Y., Duncan, M. B., Xie, L., Maeda, G., Vong, S., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2011.11.024 · Cited by 530 · see citing works
Murohara, T., Horowitz, J. R., Silver, M., Tsurumi, Y., Chen, D., Sullivan, A. B., & Isner, J. M. (1998) · Circulation · doi:10.1161/01.cir.97.1.99 · Cited by 518 · see citing works
Combining two strategies to improve perfusion and drug delivery in solid tumors
Stylianopoulos, T., & Jain, R. K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318415110 · Cited by 508 · see citing works
History of Cancer, Ancient and Modern Treatment Methods
Sudhakar, A. (2009) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.100000e2 · Cited by 507 · see citing works
Size-Tunable Strategies for a Tumor Targeted Drug Delivery System
Yu, W., Liu, R., Zhou, Y., & Gao, H. (2020) · ACS Central Science · doi:10.1021/acscentsci.9b01139 · Cited by 494 · see citing works
Chow, M. T., & Luster, A. D. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0160 · Cited by 491 · see citing works
Manzoor, A. A., Lindner, L. H., Landon, C. D., Park, J. Y., Simnick, A. J., Dreher, M. R., Das, S. K., Hanna, G., Park, W., Chilkoti, A., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1683 · Cited by 461 · see citing works
Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature.
Kong, G., Braun, R. D., & Dewhirst, M. W. (2001) · PubMed · Cited by 438 · see citing works
Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery
Matsumoto, Y., Nichols, J. W., Toh, K., Nomoto, T., Cabral, H., Miura, Y., Christie, R. J., Yamada, N., Ogura, T., Kano, M. R., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2015.342 · Cited by 412 · see citing works
Sheldon, H., Heikamp, E., Turley, H., Dragovic, R., Thomas, P. H., Oon, C. E., Leek, R., Edelmann, M. J., Kessler, B. M., Sainson, R. C. A., et al. (2010) · Blood · doi:10.1182/blood-2009-08-239228 · Cited by 409 · see citing works
McKee, T. D., Grandi, P., Mok, W., Alexandrakis, G., Insin, N., Zimmer, J. P., Bawendi, M. G., Boucher, Y., Breakefield, X. O., & Jain, R. K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2242 · Cited by 397 · see citing works
Batchelor, T. T., Gerstner, E. R., Emblem, K. E., Duda, D. G., Kalpathy–Cramer, J., Snuderl, M., Ancukiewicz, M., Polaskova, P., Pinho, M. C., Jennings, D. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318022110 · Cited by 343 · see citing works
VEGF-Induced Vascular Permeability Is Mediated by FAK
Chen, X. L., Nam, J., Jean, C., Lawson, C., Walsh, C. T., Goka, E. T., Lim, S., Tomar, A., Tancioni, I., Uryu, S. A., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.002 · Cited by 341 · see citing works
Ferrari, G. M., Ferrari, G., Cook, B., Terushkin, V., Pintucci, G., & Mignatti, P. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21706 · Cited by 340 · see citing works
Maeda, H., Tsukigawa, K., & Fang, J. Q. (2015) · Microcirculation · doi:10.1111/micc.12228 · Cited by 336 · see citing works
Passive versus Active Tumor Targeting Using RGD- and NGR-Modified Polymeric Nanomedicines
Kunjachan, S., Pola, R., Gremse, F., Theek, B., Ehling, J., Moeckel, D., Hermanns‐Sachweh, B., Pechar, M., Ulbrich, K., Hennink, W. E., et al. (2014) · Nano Letters · doi:10.1021/nl404391r · Cited by 317 · see citing works
Peterson, T. E., Kirkpatrick, N. D., Huang, Y., Farrar, C. T., Marijt, K. A., Kloepper, J., Datta, M., Amoozgar, Z., Seano, G., Jung, K., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525349113 · Cited by 317 · see citing works
Greish, K. F., Fang, J. Q., Inutsuka, T., Nagamitsu, A., & Maeda, H. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342130-00002 · Cited by 277 · see citing works
Suzuki, M., Hori, K., Abe, I., Saito, S., & Sato, H. (1981) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/67.3.663 · Cited by 268 · see citing works
Moroianu, J., & Riordan, J. (1994) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.91.5.1677 · Cited by 265 · see citing works
Zhao, Y., Cao, J., Melamed, A., Worley, M. J., Gockley, A. A., Jones, D., Nia, H. T., Zhang, Y., Stylianopoulos, T., Kumar, A. S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818357116 · Cited by 262 · see citing works
Ojha, T., Pathak, V., Shi, Y., Hennink, W. E., Moonen, C. T. W., Storm, G., Kiessling, F., & Lammers, T. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.007 · Cited by 260 · see citing works
Duan, L., Li, Y., Jin, J., Yang, F., Liu, D., Hu, K., Wang, Q., Yue, Y., & Gu, N. (2019) · Theranostics · doi:10.7150/thno.37593 · Cited by 254 · see citing works
Eikenes, L., Bruland, Ø. S., Brekken, C., & Davies, C. D. L. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1472 · Cited by 251 · see citing works
Fibroblast growth factors are required for efficient tumor angiogenesis.
Compagni, A., Wilgenbus, P., Impagnatiello, M.-A., Cotten, M. L., & Christofori, G. (2000) · PubMed · Cited by 227 · see citing works
Davis, F. B., Mousa, S. A., O’Connor, L., Mohamed, S. N., Lin, H., Cao, H. J., & Davis, P. J. (2004) · Circulation Research · doi:10.1161/01.res.0000130784.90237.4a · Cited by 225 · see citing works
Fang, J. Q., Sawa, T., & Maeda, H. (2005) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-47932-x_2 · Cited by 221 · see citing works
Maeda, H., Noguchi, Y., Sato, K., & Akaike, T. (1994) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1994.tb02362.x · Cited by 221 · see citing works
Tang, H., Lin, H., Zhang, S., Davis, F. B., & Davis, P. J. (2004) · Endocrinology · doi:10.1210/en.2004-0308 · Cited by 216 · see citing works
Wu, J., Akaike, T., & Maeda, H. (1998) · PubMed · Cited by 212 · see citing works
Placental Growth Factor (PlGF) and Its Receptor Flt‐1 (VEGFR‐1)
Luttun, A., Tjwa, M., & Carmeliet, P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04870.x · Cited by 203 · see citing works
Loeffler, S., Fayard, B., Weis, J., & Weissenberger, J. (2005) · International Journal of Cancer · doi:10.1002/ijc.20871 · Cited by 201 · see citing works
Smart Nanotherapeutic Targeting of Tumor Vasculature
Li, Z., Di, C., Li, S., Yang, X., & Nie, G. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00283 · Cited by 196 · see citing works
Dephosphorylation of Endothelial Nitric-oxide Synthase by Vascular Endothelial Growth Factor
Kou, R., Greif, D. M., & Michel, T. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204519200 · Cited by 192 · see citing works
Koukourakis, M. I., Koukouraki, S. I., Giatromanolaki, A. N., Archimandritis, S. C., Skarlatos, J., Beroukas, K., Bizakis, J. G., Retalis, G., Karkavitsas, N., & Helidonis, E. S. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.11.3512 · Cited by 191 · see citing works
Extravasation of polymeric nanomedicines across tumor vasculature
Danquah, M. K., Zhang, X. A., & Mahato, R. I. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.11.005 · Cited by 190 · see citing works
Angiopoietin-2 Stimulates Breast Cancer Metastasis through the α5β1 Integrin-Mediated Pathway
Imanishi, Y., Hu, B., Jarzynka, M. J., Guo, P., Elishaev, E., Bar-Joseph, I., & Cheng, S.-Y. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4100 · Cited by 190 · see citing works
Huber, P. E., Bischof, M., Jenne, J., Heiland, S., Peschke, P., Saffrich, R., Gröne, H., Debus, J., Lipson, K. E., & Abdollahi, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1668 · Cited by 185 · see citing works
Nagamitsu, A., Greish, K. F., & Maeda, H. (2009) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyp074 · Cited by 180 · see citing works
Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application
Seki, T., Fang, J. Q., & Maeda, H. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01323.x · Cited by 179 · see citing works
Friedl, J., Puhlmann, M., Bartlett, D. L., Libutti, S. K., Turner, E. N., Gnant, M., & Alexander, H. R. (2002) · Blood · doi:10.1182/blood.v100.4.1334.h81602001334_1334_1339 · Cited by 177 · see citing works
Epidermal growth factor receptor in tumor angiogenesis
Ellis, L. M. (2004) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2004.06.002 · Cited by 172 · see citing works
Li, S., Zhang, Y., Wang, J., Zhao, Y., Ji, T., Zhao, X., Ding, Y., Zhao, X., Zhao, R., Li, F., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0115-8 · Cited by 171 · see citing works
Laschke, M. W., Elitzsch, A., Vollmar, B., Vajkoczy, P., & Menger, M. (2005) · Human Reproduction · doi:10.1093/humrep/dei308 · Cited by 168 · see citing works
Involvement of the Kinin‐generating Cascade in Enhanced Vascular Permeability in Tumor Tissue
Matsumura, Y., Kimura, M., Yamamoto, T., & Maeda, H. (1988) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1988.tb01563.x · Cited by 163 · see citing works
Enhanced Vascular Permeability in Solid Tumor Involving Peroxynitrite and Matrix Metalloproteinases
Wu, J., Akaike, T., Hayashida, K., Okamoto, T., Okuyama, A., & Maeda, H. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb01114.x · Cited by 152 · see citing works
Jeon, S.-H., Chae, B.-C., Kim, H.-A., Seo, G., Seo, D. W., Chun, G., Kim, N., Yie, S.-W., Byeon, W.-H., Eom, S., et al. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0806517 · Cited by 150 · see citing works
Kok, R. J., Schraa, A. J., Bos, E. J., Moorlag, H. E., Ásgeirsdóttir, S. A., Everts, M., Meijer, D. K. F., & Molema, G. (2001) · Bioconjugate Chemistry · doi:10.1021/bc015561+ · Cited by 146 · see citing works
Polymer Therapeutics for Cancer: Current Status and Future Challenges
Satchi‐Fainaro, R., Duncan, R., & Barnés, C. M. (2005) · Springer eBooks · doi:10.1007/12_024 · Cited by 145 · see citing works
Srivastava, K., Hu, J., Korn, C., Savant, S., Teichert, M., Kapel, S. S., Jugold, M., Besemfelder, E., Thomas, M., Pasparakis, M., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.11.005 · Cited by 140 · see citing works
Park, J. S., Qiao, L., Su, Z.-Z., Hinman, D., Willoughby, K. A., McKinstry, R. P., Yacoub, A., Duigou, G. J., Young, C. S. H., Grant, S., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204258 · Cited by 139 · see citing works
Maeda, H., Matsumura, Y., & Kato, H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37555-0 · Cited by 128 · see citing works
Anisamide-targeted cyclodextrin nanoparticles for siRNA delivery to prostate tumours in mice
Guo, J., Ogier, J. R., Desgranges, S., Darcy, R., & O’Driscoll, C. M. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.07.012 · Cited by 127 · see citing works
Investigating the EPR effect of nanomedicines in human renal tumors via ex vivo perfusion strategy
Ding, Y., Xu, Y., Yang, W., Niu, P., Li, X., Chen, Y., Li, Z., Liu, Y., An, Y., Liu, Y., et al. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100970 · Cited by 127 · see citing works
Self-citationLammers, T., Peschke, P., Kühnlein, R., Subr, V., Ulbrich, K., Debus, J., Huber, P., Hennink, W., & Storm, G. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.10.032 · Cited by 124 · see citing works
Koukouraki, A. M. I. K. S. (2000) · Acta Oncologica · doi:10.1080/028418600430789 · Cited by 122 · see citing works
Chen, Y., Gu, H., Zhang, D. S., Fan, L., Liu, T., & Xia, W. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.09.003 · Cited by 117 · see citing works
Self-citationTargeting tumor microenvironment: crossing tumor interstitial fluid by multifunctional nanomedicines
Omidi, Y., & Barar, J. (2014) · Europe PMC (PubMed Central) · doi:10.5681/bi.2014.021 · Cited by 116 · see citing works
Li, B., Vincent, A., Cates, J., Brantley-Sieders, D. M., Polk, D. B., & Young, P. P. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1565 · Cited by 115 · see citing works
Yang, Y., Zhang, Y., Iwamoto, H., Hosaka, K., Seki, T., Andersson, P., Lim, S., Fischer, C., Nakamura, M., Abe, M., et al. (2016) · Nature Communications · doi:10.1038/ncomms12680 · Cited by 113 · see citing works
Permeability properties of tumor surrogate blood vessels induced by VEGF-A
Nagy, J. A., Feng, D., Vasile, E., Wong, W. H., Shih, S., Dvořàk, A. M., & Dvorak, H. F. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700436 · Cited by 112 · see citing works
Biomimetic carriers mimicking leukocyte plasma membrane to increase tumor vasculature permeability
Palomba, R., Parodi, A., Evangelopoulos, M., Acciardo, S., Corbo, C., Rosa, E. D., Yazdi, I. K., Scaria, S., Molinaro, R., Furman, N. E. T., et al. (2016) · Scientific Reports · doi:10.1038/srep34422 · Cited by 112 · see citing works
Mousa, S. A., Bergh, J. J., Dier, E., Rebbaa, A., O’Connor, L. J., Yalçın, M., Aljada, A., Dyskin, E., Davis, F. B., Lin, H.-Y., et al. (2007) · Angiogenesis · doi:10.1007/s10456-007-9088-7 · Cited by 108 · see citing works
Oehler, M. K., Hague, S. J., REES, M. C. P., & Bicknell, R. (2002) · Oncogene · doi:10.1038/sj.onc.1205374 · Cited by 108 · see citing works
Jordan, B. F., Misson, P., Demeure, R., Baudelet, C., Beghein, N., & Gallez, B. (2000) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(00)00694-5 · Cited by 107 · see citing works
Kinin‐generating Cascade in Advanced Cancer Patients and in vitro Study
Matsumura, Y., Maruo, K., Kimura, M., Yamamoto, T., Konno, T., & Maeda, H. (1991) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1991.tb01910.x · Cited by 104 · see citing works
Chen, L., Zhao, T., Zhao, M., Wang, W., Sun, C., Liu, L., Li, Q., Zhang, F., Zhao, D., & Li, X. (2020) · Chemical Science · doi:10.1039/c9sc06260b · Cited by 104 · see citing works
AdTIMP-2 Inhibits Tumor Growth, Angiogenesis, and Metastasis, and Prolongs Survival in Mice
Li, H., Lindenmeyer, F., Grenet, C., Opolon, P., Ménashi, S., Soria, C., Yeh, P., Perricaudet, M., & Lu, H. (2001) · Human Gene Therapy · doi:10.1089/104303401300042429 · Cited by 101 · see citing works
Yin, H., Fang, J. Q., Liao, L., Nakamura, H., & Maeda, H. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.018 · Cited by 99 · see citing works
Islam, W., Fang, J. Q., Imamura, T., Etrych, T., Šubr, V., Ulbrich, K., & Maeda, H. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0696 · Cited by 97 · see citing works
Efficient siRNA delivery using water soluble lipopolymer for anti-angiogenic gene therapy
Kim, W. J., Chang, C., Lee, M., & Kim, S. W. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.12.026 · Cited by 95 · see citing works
Enhanced Nanodrug Delivery to Solid Tumors Based on a Tumor Vasculature‐Targeted Strategy
Song, C., Zhang, Y., Li, C., Chen, G., Kang, X., & Wang, Q. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201600417 · Cited by 95 · see citing works
Greish, K. F. (2011) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2011.11.010 · Cited by 92 · see citing works
Parenteral hyperalimentation in surgical patients with head and neck cancer: A randomized study
Sako, K., Loré, J. M., Kaufman, S., Razack, M. S., Bakamjian, V. Y., & Reese, P. A. (1981) · Journal of Surgical Oncology · doi:10.1002/jso.2930160413 · Cited by 92 · see citing works
Nanotechnology for the Development of Nanomedicine
Tekade, R. K., Maheshwari, R., Soni, N., Tekade, M., & Chougule, M. B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809717-5.00001-4 · Cited by 90 · see citing works
Zhang, M., Ye, J.-J., Xia, Y., Wang, Z.-Y., Li, C.-X., Wang, X.-S., Yu, W., Song, W., Feng, J., & Zhang, X.-Z. (2019) · ACS Nano · doi:10.1021/acsnano.9b07330 · Cited by 89 · see citing works
Vincent, L., Varet, J., Pille, J., Bompais, H., Opolon, P., Maksimenko, A., Malvy, C., Mirshahi, M., Lu, H., Vannier, J., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.11105 · Cited by 88 · see citing works
Song, C., Li, Y., Li, T., Yang, Y., Huang, Z., de la Fuente, J. M., Ni, J., & Cui, D. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201906309 · Cited by 85 · see citing works
Kim, W. J., Yockman, J. W., Jeong, J. H., Christensen, L. V., Lee, M., Kim, Y., & Kim, S. W. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.05.029 · Cited by 84 · see citing works
Fang, J. Q., Qin, H., Nakamura, H., Tsukigawa, K., Shin, T., & Maeda, H. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02178.x · Cited by 84 · see citing works
Shenoi, M. M., Iltis, I., Choi, J., Koonce, N. A., Metzger, G. J., Griffin, R. J., & Bischof, J. C. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300505w · Cited by 83 · see citing works
Increased Efficacy of Breast Cancer Chemotherapy in Thrombocytopenic Mice
Demers, M., Ho‐Tin‐Noé, B., Schatzberg, D., Yang, J. J., & Wagner, D. D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2038 · Cited by 83 · see citing works
Dai, L., Li, X., Yao, M., Niu, P., Yuan, X., Li, K., Chen, M., Fu, Z., Duan, X., Liu, H., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119901 · Cited by 81 · see citing works
Tumor angiogenesis and anti-angiogenic therapies
Shahneh, F. Z., Baradaran, B., Zamani, F., & Maleki, L. A. (2013) · Human Antibodies · doi:10.3233/hab-130267 · Cited by 80 · see citing works
Vasodilator Hydralazine Promotes Nanoparticle Penetration in Advanced Desmoplastic Tumors
Chen, Y., Song, W., Shen, L., Qiu, N., Hu, M., Liu, Y., Liu, Q., & Huang, L. (2019) · ACS Nano · doi:10.1021/acsnano.8b07830 · Cited by 79 · see citing works
Self-citationThe Chemical Properties of Nitric Oxide and Related Nitrogen Oxides
Fukuto, J. M., Cho, J. Y., & Switzer, C. H. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50003-4 · Cited by 78 · see citing works
Human IL-3 Stimulates Endothelial Cell Motility and Promotes In Vivo New Vessel Formation
Dentelli, P., Sorbo, L. D., Rosso, A., Molinar, A., Garbarino, G. M., Camussi, G., Pegoraro, L., & Brizzi, M. F. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.2151 · Cited by 76 · see citing works
Liang, C., Chao, Y., Yi, X., Xu, J., Feng, L., Zhao, Q., Yang, K., & Liu, Z. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.01.033 · Cited by 75 · see citing works
Gu, H., Chen, Y., Wang, X., Liu, T., Zhang, D. S., Wang, Y., & Di, W. J. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s78774 · Cited by 74 · see citing works
Self-citationHuang, Y., Tong, Z., Sun, S., & Mao, Z. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.024 · Cited by 70 · see citing works
Kanazawa, T., Sugawara, K., Tanaka, K., Horiuchi, S., Takashima, Y., & Okada, H. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.04.021 · Cited by 67 · see citing works
Rebbaa, A., Chu, F., Davis, F. B., Davis, P. J., & Mousa, S. A. (2008) · Angiogenesis · doi:10.1007/s10456-008-9110-8 · Cited by 64 · see citing works
Expression of Tissue Kallikrein and Kinin Receptors in Angiogenic Microvascular Endothelial Cells
Plendl, J., Snyman, C., Naidoo, S., Sawant, S., Mahabeer, R., & Bhoola, K. D. (2000) · Biological Chemistry · doi:10.1515/bc.2000.135 · Cited by 64 · see citing works
Interleukin-1β Regulates Angiopoietin-1 Expression in Human Endothelial Cells
Fan, F., Stoeltzing, O., Liu, W., McCarty, M. F., Jung, Y. D., Reinmuth, N., & Ellis, L. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-0407 · Cited by 62 · see citing works
Hori, K., Suzuki, M., Tanda, S., Saito, S., Shinozaki, M., & Zhang, Q. (1991) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1991.tb01797.x · Cited by 60 · see citing works
Tanaka, S., Akaike, T., Wu, J., Fang, J. Q., Sawa, T., Ogawa, M., Beppu, T., & Maeda, H. (2003) · Journal of drug targeting · doi:10.1080/1061186031000086072 · Cited by 59 · see citing works
Taylor, A. P., Rodriguez, M., Adams, K., Goldenberg, D. M., & Blumenthal, R. D. (2003) · International Journal of Cancer · doi:10.1002/ijc.11059 · Cited by 58 · see citing works
Targeting Angiogenesis for Controlling Neuroblastoma
Choudhury, S. R., Karmakar, S., Banik, N. L., & Ray, S. K. (2011) · Journal of Oncology · doi:10.1155/2012/782020 · Cited by 57 · see citing works
Wang, K., Tu, Y., Wang, Y., Zong, Q., Xiao, X., Yang, R., Jiang, X., & Yuan, Y. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b21525 · Cited by 57 · see citing works
Satchi‐Fainaro, R., & Duncan, R. (2005) · Advances in polymer science · doi:10.1007/11547785 · Cited by 56 · see citing works
Satterlee, A., Rojas, J. D., Dayton, P. A., & Huang, L. (2016) · Theranostics · doi:10.7150/thno.16681 · Cited by 56 · see citing works
Self-citationHypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome
Dulloo, I., Phang, B. H., Othman, R., Tan, S., Vijayaraghavan, A., Goh, L. K., Martín‐López, M., Marqués, M. M., Li, C. W., Wang, D. Y., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3130 · Cited by 54 · see citing works
Xiao, J., Duan, X., Yin, Q., Miao, Z., Yu, H., Chen, C., Zhang, Z., Wang, J., & Li, Y. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.084 · Cited by 54 · see citing works
Zhen, M., Shu, C., Li, J., Zhang, G., Wang, T., Luo, Y., Zou, T., Deng, R., Fang, F., Lei, H. C., et al. (2015) · Science China Materials · doi:10.1007/s40843-015-0089-3 · Cited by 54 · see citing works
Seki, T., Carroll, F., Illingworth, S., Green, N., Cawood, R., Bachtarzi, H., Šubr, V., Fisher, K. D., & Seymour, L. W. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.022 · Cited by 53 · see citing works
Jin, Y., Wu, Z., Wu, C., Zi, Y., Chu, X., Liu, J., & Zhang, W. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.01.040 · Cited by 53 · see citing works
Gao, Y., Shi, Y., Fu, M., Feng, Y., Lin, G., Kong, D., & Jiang, B. Q. (2020) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2020.105493 · Cited by 50 · see citing works
The discovery of angiogenic growth factors: the contribution of Italian scientists
Ribatti, D. (2014) · Vascular Cell · doi:10.1186/2045-824x-6-8 · Cited by 48 · see citing works
Sun, C., Jain, R. K., & Munn, L. L. (2007) · Annals of Biomedical Engineering · doi:10.1007/s10439-007-9377-8 · Cited by 47 · see citing works
Combined endostatin/sFlt‐1 antiangiogenic gene therapy is highly effective in a rat model of HCC†
Graepler, F., Verbeek, B., Graeter, T., Smirnow, I., Kong, H. L., Schuppan, D., Bauer, M. W., Vonthein, R., Gregor, M., & Lauer, U. M. (2005) · Hepatology · doi:10.1002/hep.20613 · Cited by 46 · see citing works
Sakae, M., Ito, T., Yoshihara, C., Iida‐Tanaka, N., Yanagië, H., Eriguchi, M., & Koyama, Y. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2007.12.009 · Cited by 46 · see citing works
Hori, K., Saito, S., Takahashi, H., Sato, H., Maeda, H., & Sato, Y. (2000) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2000.tb00940.x · Cited by 45 · see citing works
Fang, J. Q., Qin, H., Seki, T., Nakamura, H., Tsukigawa, K., Shin, T., & Maeda, H. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.185348 · Cited by 44 · see citing works
Daruwalla, J., Greish, K. F., Malcontenti‐Wilson, C., Muralidharan, V., Iyer, A. K., Maeda, H., & Christophi, C. (2008) · Journal of Vascular Research · doi:10.1159/000165380 · Cited by 43 · see citing works
Zhang, B., Jiang, T., Tuo, Y., Jin, K., Luo, Z., Shi, W., Mei, H., Hu, Y., Pang, Z., & Jiang, X. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.09.007 · Cited by 41 · see citing works
Huang, Z., Dong, L., Chen, J., Gao, F., Zhang, Z., Chen, J., & Zhang, J. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.09.015 · Cited by 40 · see citing works
Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth
Oon, C. E., Bridges, E., Sheldon, H., Sainson, R. C. A., Jubb, A. M., Turley, H., Leek, R., Buffa, F. M., Harris, A. L., & Li, J. (2017) · Oncotarget · doi:10.18632/oncotarget.16969 · Cited by 40 · see citing works
Zhang, Y., Liu, Y., Gao, X., Li, X., Niu, X., Yuan, Z., & Wang, W. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.04.022 · Cited by 39 · see citing works
Hepatocyte growth factor is an invasion/migration factor of rat urothelial carcinoma cells in vitro
Tamatani, T. (1999) · Carcinogenesis · doi:10.1093/carcin/20.6.957 · Cited by 38 · see citing works
Li, X., Zhen, M., Deng, R., Yu, T., Li, J., Zhang, Y., Zou, T., Zhou, Y., Lu, Z., Guan, M., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.028 · Cited by 35 · see citing works
Mei, T., Shashni, B., Maeda, H., & Nagasaki, Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120290 · Cited by 33 · see citing works
Kim, J., Kim, S. W., & Kim, W. J. (2011) · Oligonucleotides · doi:10.1089/oli.2011.0278 · Cited by 32 · see citing works
Targeting platelet function to improve drug delivery
Demers, M., & Wagner, D. D. (2012) · OncoImmunology · doi:10.4161/onci.1.1.17962 · Cited by 32 · see citing works
Yang, Z. (2011) · Oncology Reports · doi:10.3892/or.2011.1318 · Cited by 30 · see citing works
Yu, H., Lin, T., & Tang, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140713329 · Cited by 30 · see citing works
Nanobiomaterials in cancer therapy
Srinivasan, M., Rajabi, M., & Mousa, S. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-42863-7.00003-7 · Cited by 30 · see citing works
Antiangiogenic anticancer strategy based on nanoparticulate systems
Yoncheva, K., & Momekov, G. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.585155 · Cited by 27 · see citing works
Shima, N., Stolz, D. B., Miyazaki, M., Gohda, E., Higashio, K., & Michalopoulos, G. K. (1998) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199810)177:1 · Cited by 26 · see citing works
In vitro and in vivo study of hydralazine, a potential anti-angiogenic agent
Zhang, Q., Lin, Z., Yin, X.-K., Tang, L.-Z., Luo, H., Li, H., Zhang, Y., & Luo, W. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.021 · Cited by 26 · see citing works
Li, L., Yang, J., Wang, W., Yao, Y.-C., Fang, S., Dai, Z., Hong, H., Yang, X., Shuai, X., & Gao, G. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.08.043 · Cited by 24 · see citing works
Zhang, P., Zhang, Y. X., Ding, X., Xiao, C., & Chen, X. (2020) · Biomaterials Science · doi:10.1039/d0bm00466a · Cited by 23 · see citing works
Inhibition of metastatic brain tumor growth by intramuscular administration of the endostatin gene
Oga, M., Takenaga, K., Satô, Y., Nakajima, H., Koshikawa, N., Osato, K., & Sakiyama, S. (2003) · International Journal of Oncology · doi:10.3892/ijo.23.1.73 · Cited by 19 · see citing works
Generation of Expression Plasmids for Angiostatin, Endostatin and Timp-2 for Cancer Gene Therapy
Indraccolo, S., Minuzzo, S. A., Gola, E., Habeler, W., Carrozzino, F., Noonan, D. M., Albini, A., Santi, L., Amadori, A., & Chieco‐Bianchi, L. (1999) · The International Journal of Biological Markers · doi:10.1177/172460089901400410 · Cited by 19 · see citing works
MAKING UP OR BREAKING UP: THE TORTUOUS ROLE OF PLATELET‐DERIVED GROWTH FACTOR IN VASCULAR AGEING
Yang, X., Pei, Z., & Ren, J. T. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05182.x · Cited by 18 · see citing works
Rajabi, M., Sudha, T., Darwish, N. H. E., Davis, P. J., & Mousa, S. A. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.06.064 · Cited by 15 · see citing works
Steins, A., Klaassen, R., Jacobs, I., Schabel, M. C., van Lier, M. G. J. T. B., Ebbing, E. A., Hectors, S. J. C. G., Tas, S. W., Maracle, C. X., Punt, C. J. A., et al. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12599 · Cited by 12 · see citing works
Farahani, A., Azimi, S., Tajaddodi, A., Docoslis, A., & Tashakori, C. (2020) · Talanta · doi:10.1016/j.talanta.2020.121518 · Cited by 10 · see citing works
Property of Nano-thickness Nickel Silicides with Low Temperature Catalytic CVD
Choi, Y., Kim, K., Park, J., & Song, O. (2010) · 대한금속재료학회지 · doi:10.3365/kjmm.2010.48.02.133 · Cited by 3 · see citing works
(2005) · Springer eBooks · doi:10.1007/3-540-29623-9_9041
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An Updated Review on EPR-Based Solid Tumor Targeting Nanocarriers for Cancer Treatment
Sharifi, M., Cho, W. C. S., Ansariesfahani, A., Tarharoudi, R., Malekisarvar, H., Sari, S., Bloukh, S. H., Edis, Z., Amin, M., Gleghorn, J. P., et al. (2022) · Cancers · doi:10.3390/cancers14122868 · Cited by 180 · see citing works
Targeted Delivery Methods for Anticancer Drugs
Veselov, V. V., Nosyrev, A. E., Jicsinszky, L., Alyautdin, R. N., & Cravotto, G. (2022) · Cancers · doi:10.3390/cancers14030622 · Cited by 180 · see citing works
Stimuli-Responsive Polymeric Nanoplatforms for Cancer Therapy
Chang, D., Ma, Y., Xu, X., Xie, J., & Ju, S. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.707319 · Cited by 169 · see citing works
Understanding nanoparticle-liver interactions in nanomedicine
He, Y., Wang, Y., Wang, L., Jiang, W., & Wilhelm, S. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2375400 · Cited by 140 · see citing works
Pan, Y., Tang, W., Fan, W., Zhang, J., & Chen, X. S. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01145f · Cited by 125 · see citing works
Advances and applications of nanoparticles in cancer therapy
Huang, X., He, T., Liang, X., Xiang, Z., Liu, C., Zhou, S., Luo, R., Bai, L., Kou, X., Li, X., et al. (2024) · MedComm – Oncology · doi:10.1002/mog2.67 · Cited by 123 · see citing works
Self-citationTargeting endothelial permeability in the EPR effect
Lahooti, B., Akwii, R. G., Zahra, F. T., Sajib, M. S., Λάμπρου, Μ., Alobaida, A., Lionakis, M. S., Mattheolabakis, G., & Mikelis, C. M. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.07.039 · Cited by 106 · see citing works
Targeting Peptides: The New Generation of Targeted Drug Delivery Systems
Todaro, B., Ottalagana, E., Luin, S., & Santi, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061648 · Cited by 100 · see citing works
Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis
Subhan, M. A., Parveen, F., Filipczak, N., Yalamarty, S. S. K., & Torchilin, V. P. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13030389 · Cited by 98 · see citing works
Zheng, Y., Wang, Y., Xia, M., Gao, Y., Zhang, L., Song, Y., & Zhang, C. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01029-x · Cited by 89 · see citing works
Li, S., Chen, Z., Tan, L., Wu, Q., Ren, X., Fu, C., Niu, M., Li, H., & Meng, X. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121472 · Cited by 87 · see citing works
“Targeting Design” of Nanoparticles in Tumor Therapy
Yang, T., Zhai, J., Hu, D., Yang, R., Wang, G., Li, Y., & Liang, G. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091919 · Cited by 84 · see citing works
Mechanical forces in the tumor microenvironment: roles, pathways, and therapeutic approaches
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Granja, A., Nunes, C., Sousa, C. T., & Reis, S. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113525 · Cited by 75 · see citing works
Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy
Kumar, S., Shukla, M. K., Sharma, A. K., Jayaprakash, G. K., Tonk, R. K., Chellappan, D. K., Singh, S. K., Dua, K., Ahmed, F., Bhattacharyya, S., et al. (2023) · MedComm · doi:10.1002/mco2.253 · Cited by 74 · see citing works
Bispecific antibodies for targeted delivery of anti-cancer therapeutic agents: A review
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Li, Y., Ke, J., Jia, H., Ren, J., Wang, L., Zhang, Z., & Wang, C. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113131 · Cited by 57 · see citing works
Novel EPR-enhanced strategies for targeted drug delivery in pancreatic cancer: An update
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Recent advances and application of ruthenium complexes in tumor malignancy
Kanaoujiya, R., Meenakshi, Srivastava, S., Singh, R., & Mustafa, G. (2022) · Materials Today Proceedings · doi:10.1016/j.matpr.2022.07.098 · Cited by 50 · see citing works
Granja, A., Lima‐Sousa, R., Alves, C. G., de Melo‐Diogo, D., Pinheiro, M., Sousa, C. T., Correia, I. J., & Reis, S. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121044 · Cited by 48 · see citing works
Graphene-based hybrid composites for cancer diagnostic and therapy
Asadi, M., Ghorbani, S. H., Mahdavian, L., & Aghamohammadi, M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05438-7 · Cited by 47 · see citing works
Recent advances in metal/metal-oxide nanoparticle-polymer nanohybrid for biomedical applications
Bamisaye, A., Adekola, M. A., Abati, S. M., Etafo, N. O., Ademola, O. S., Joseph, P. T., Samuel, O., Ogunlaja, O. O., Langmi, H. W., & Idowu, M. A. (2025) · Materials Today Chemistry · doi:10.1016/j.mtchem.2025.103086 · Cited by 38 · see citing works
Recent advances in PLGA-based nanofibers as anticancer drug delivery systems
Razavi, M. S., Abdollahi, A., Malek-Khatabi, A., Ejarestaghi, N. M., Atashi, A., Yousefi, N., Ebrahimnejad, P., Elsawy, M. A., & Dinarvand, R. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104587 · Cited by 37 · see citing works
Shen, J.-J., Xue, S.-J., Mei, Z.-H., Li, T.-T., Li, H., Zhuang, X.-F., & Pan, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28066 · Cited by 35 · see citing works
Buyukgolcigezli, I., Tenekeci, A. K., & Şahin, İ. H. (2025) · Cancers · doi:10.3390/cancers17060958 · Cited by 36 · see citing works
Bioinspired and Biomimetic Nanomedicines for Targeted Cancer Therapy
Xu, X., Li, T., & Jin, K. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051109 · Cited by 36 · see citing works
Targeted drug delivery systems for elemene in cancer therapy: The story thus far
Tian, H., Zhao, F., Qi, Q.-R., Yue, B., & Zhai, B. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115331 · Cited by 35 · see citing works
Boltman, T., Meyer, M., & Ekpo, O. E. (2023) · Cancers · doi:10.3390/cancers15133388 · Cited by 34 · see citing works
Jiao, R., Lin, X., Zhang, Q., Zhang, Y., Qin, W., Yang, Q., Xu, C. S., Chen, F., & Zhang, K. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101230 · Cited by 34 · see citing works
Luo, N., Liu, L., Luo, J., Zhou, Z., Sun, C., Hua, X., Luo, L., Wang, J., Geng, H., Shao, X., et al. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202418047 · Cited by 33 · see citing works
Moni, S. S., Moshi, J. M., Matou‐Nasri, S., Alotaibi, S., Hawsawi, Y. M., Elmobark, M. E., Hakami, A., Jeraiby, M., Sulayli, A. A., & Moafa, H. N. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030296 · Cited by 35 · see citing works
Targeting nanoparticles to malignant tumors
Sharma, N., Bietar, K., & Stochaj, U. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188703 · Cited by 34 · see citing works
Giribaldi, J., Smith, J. J. L., & Schroeder, C. I. (2021) · Biotechnology Advances · doi:10.1016/j.biotechadv.2021.107769 · Cited by 32 · see citing works
Wu, L., Wang, C., & Li, Y. (2022) · Nanomedicine · doi:10.2217/nnm-2022-0246 · Cited by 32 · see citing works
EPR Effect-Based Tumor Targeted Nanomedicine: A Promising Approach for Controlling Cancer
Fang, J. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12010095 · Cited by 31 · see citing works
Nanotechnology-based combinatorial phototherapy for enhanced cancer treatment
Chen, H., Timashev, P. S., Zhang, Y., Xue, X., & Liang, X. (2022) · RSC Advances · doi:10.1039/d1ra09067d · Cited by 31 · see citing works
Strategies to enhance the penetration of nanomedicine in solid tumors
Liu, S., Ren, Z., Yan, M., Ye, W., & Hu, Y. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123315 · Cited by 30 · see citing works
Saadh, M., Mustafa, M. A., Kumar, A., Alamir, H. T. A., Kumar, A., Khudair, S. A., Faisal, A., Alubiady, M. H. S., Jalal, S. S., Shafik, S., et al. (2024) · AAPS PharmSciTech · doi:10.1208/s12249-024-02843-5 · Cited by 23 · see citing works
Ifijen, I. H., Awoyemi, C. T., Lekan, O. K., Aworinde, O. R., Faderin, E., Oluwafunke, O., Akanji, T. F. A., Igboanugo, J. C., Udogu, U., Ogidi, G. O., et al. (2024) · RSC Advances · doi:10.1039/d4ra05732e · Cited by 29 · see citing works
Polymer-based nanoparticles for cancer theranostics: advances, challenges, and future perspectives
Shanahan, K., Coen, D., & Nafo, W. (2025) · Exploration of BioMat-X · doi:10.37349/ebmx.2025.101342 · Cited by 29 · see citing works
Ando, H., Ikeda, A., Tagami, M., Matsuo, N. C. A., Shimizu, T., Ishima, Y., Eshima, K., & Ishida, T. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.031 · Cited by 28 · see citing works
Improving Tumor Targeting and Penetration for Nanoparticle‐Mediated Cancer Therapy
Luo, Z., Chen, C., & Li, S. (2025) · Small Methods · doi:10.1002/smtd.202401860 · Cited by 27 · see citing works
The Development of Live Microorganism-Based Oxygen Shuttles for Enhanced Hypoxic Tumor Therapy
Han, D., Zhang, X., Ma, Y., Yang, X., & Li, Z. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100517 · Cited by 25 · see citing works
Arya, D. K., Deshpande, H., Kumar, A., Chidambaram, K., Pandey, P., Anjum, S., Deepak, P., Kumar, V., Kumar, S., Pandey, G., et al. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16091128 · Cited by 25 · see citing works
Enhancing Cancer Immunotherapeutic Efficacy with Sonotheranostic Strategies
Zafar, A., Hasan, M., Tariq, T., & Dai, Z. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00437 · Cited by 25 · see citing works
Huang, J., Zhang, L., Zheng, J., Lin, Y., Leng, X., Wang, C., Li, P., & Feng, L. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122181 · Cited by 25 · see citing works
Shahbaz, S., Esmaeili, M., Nasab, M. H. F., Imani, Z., Bafkary, R., Amini, M., Atyabi, F., & Dinarvand, R. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124024 · Cited by 24 · see citing works
Microbial‐Enabled Photosynthetic Oxygenation for Disease Treatment
Yang, Z., Li, P., Feng, W., & Chen, Y. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202305866 · Cited by 26 · see citing works
Self-citationChen, M., Tang, X., Li, J., Chen, F., Jiang, Z.-T., Fu, R., Li, H., Hu, X., Geng, W., & Guo, D. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.03.017 · Cited by 24 · see citing works
Recent advancements in nanoparticles for cancer treatment
Sharma, D. K. (2025) · Medical Oncology · doi:10.1007/s12032-025-02609-4 · Cited by 23 · see citing works
Singh, D., & Kumar, A. (2025) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2025.1002355 · Cited by 23 · see citing works
Lankoff, A., Czerwińska, M., Walczak, R., Karczmarczyk, U., Tomczyk, K., Brzóska, K., Fracasso, G., Garnuszek, P., Mikołajczak, R., & Kruszewski, M. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115702 · Cited by 23 · see citing works
Zhang, L., Guo, Q., Zheng, R., Yu, Q., Liang, Y., Ma, G., Li, Q., Zhang, X., Xiao, H., & Wang, L. (2023) · Langmuir · doi:10.1021/acs.langmuir.3c00159 · Cited by 23 · see citing works
Wang, H., Shao, W., Lu, X., Gao, C., Fang, L., Yang, X., & Zhu, P. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124208 · Cited by 23 · see citing works
Solid Lipid Nanoparticles, an Alternative for the Treatment of Triple-Negative Breast Cancer
Munive, M. L., Vazquez-Lopez, M. I., & García‐López, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910712 · Cited by 20 · see citing works
Ultrasmall MnSe Nanoparticles as T1-MRI Contrast Agents for In Vivo Tumor Imaging
Chen, S., Huang, L., Huang, B., Zhang, M., Li, H., Pang, D., Zhang, Z., & Cui, R. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c25101 · Cited by 20 · see citing works
Self-citationSharma, A. K., Singh, M., Sharma, V., Vashishth, A., Raj, M., Upadhyay, S. K., Singh, S., Ramniwas, S., Dhama, K., Sharma, A. K., et al. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.113745 · Cited by 20 · see citing works
Zhang, J., Li, D., Zhang, R., Peng, R., & Li, J. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211035689 · Cited by 20 · see citing works
Tian, M., Dong, B., Li, W., Wang, L., & Yu, H. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16101339 · Cited by 17 · see citing works
Targeted therapies against breast cancer: Clinical perspectives, obstacles and new opportunities
Nagpal, D., Verma, R., Mittal, V., Jeandet, P., & Kaushik, D. K. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105049 · Cited by 17 · see citing works
Lu, Z., Liu, J., Zhao, L., Wang, C., Shi, F., Li, Z., Liu, X., & Miao, Z. (2023) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2023.2175850 · Cited by 16 · see citing works
Advances in nanoparticle mediated targeting of RNA binding protein for cancer
Kashikar, R., Kotha, A. K., Shah, S., Famta, P., Singh, S. B., Srivastava, S., & Chougule, M. B. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114257 · Cited by 16 · see citing works
Masuda, N., Ono, M., Mukohara, T., Yasojima, H., Shimoi, T., Kobayashi, K., Harano, K., Mizutani, M., Tanioka, M., Takahashi, S., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.03.004 · Cited by 15 · see citing works
Nemakhavhani, L., Abrahamse, H., & Kumar, S. S. D. (2024) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2024.2368033 · Cited by 15 · see citing works
Tumor vasculature associated nanomedicine strategies
Wang, X., Song, X., Wei, Q., Wang, W., Xu, H., & Dong, X. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216189 · Cited by 15 · see citing works
Lee, J., Cho, H., Kim, J., Lim, J., Kang, Y., & Kim, W. J. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.02.072 · Cited by 15 · see citing works
PEGylated Cisplatin Nanoparticles for Treating Colorectal Cancer in a pH-Responsive Manner
Li, W., Sun, Y., Chen, J., Jiang, Z., & Yang, J. (2022) · Journal of Immunology Research · doi:10.1155/2022/8023915 · Cited by 15 · see citing works
Lee, H. W., Seo, H. S., Yeom, S.-Y., Kim, S.-N., Kim, C. R., Park, D.-H., Park, W., Choy, Y. B., Park, C. G., & Seo, S. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012634 · Cited by 14 · see citing works
Su, M., Zhang, Y. X., Yang, L., Li, H., Li, X., Feng, J., Jia, L., & Zhang, Z. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105657 · Cited by 13 · see citing works
Tanzadehpanah, H., Mahaki, H., Manoochehri, H., Soleimani, M., & Najafi, R. (2022) · Journal of Nanoparticle Research · doi:10.1007/s11051-022-05630-0 · Cited by 13 · see citing works
Nanotechnology in cancer therapeutics, diagnosis, and management
Hazarika, D., Sarma, S., & Shankarishan, P. (2024) · Biotechnologia · doi:10.5114/bta.2024.141807 · Cited by 12 · see citing works
Application of nanomaterials in precision treatment of lung cancer
Zhang, C., Fan, J., & Wu, L. (2024) · iScience · doi:10.1016/j.isci.2024.111704 · Cited by 11 · see citing works
Yuan, J., Ding, L., Han, L., Pang, L., Zhang, P., Yang, X. Q., Liu, H., Zheng, M., Zhang, Y., & Luo, W. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.030 · Cited by 10 · see citing works
Improving SERS bioimaging of subcutaneous phantom in vivo with optical clearing
Khlebtsov, B. N., Буров, А. М., Pylaev, T. E., Савкина, А. А., Сергеевна, П. Е., Bratashov, D. N., & Khlebtsov, N. G. (2021) · Journal of Biophotonics · doi:10.1002/jbio.202100281 · Cited by 10 · see citing works
Advancement of magnetic particle imaging in diagnosis and therapy
Harini, K., Girigoswami, K., Pallavi, P., Gowtham, P., Prabhu, A. D., & Girigoswami, A. (2024) · Advances in Natural Sciences Nanoscience and Nanotechnology · doi:10.1088/2043-6262/ad3b7a · Cited by 9 · see citing works
Abbasi, E., Ghamkhari, A., Ghorbani, M., Salati, M. A., & Abbasi, F. (2024) · Journal of Polymer Research · doi:10.1007/s10965-024-04000-9 · Cited by 9 · see citing works
Luo, N., Liu, L., Luo, J., Zhou, Z., Sun, C., Hua, X., Luo, L., Wang, J., Geng, H., Shao, X., et al. (2024) · Angewandte Chemie · doi:10.1002/ange.202418047 · Cited by 9 · see citing works
Hsu, C., Ahmed, A. Y., Ullah, M. I., Ballal, S., Singh, A., Kavitha, V. S. N. P., Nathiya, D., Abdulhussain, M. A., Abass, M. A., & Hashemzadeh, A. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145514 · Cited by 9 · see citing works
Application of Nanotechnology in TACE Treatment of Liver Cancer
Yao, L., Gao, Z., Wei, X., Wang, S., Cao, W., Deng, W., Li, X., Zhang, Z., Wang, S., Zhang, Y., et al. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s527518 · Cited by 9 · see citing works
Chennamsetty, S., Keerikkadu, M., Shetty, A., Bangera, P. D., Tippavajhala, V. K., & Rathnanand, M. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126400 · Cited by 12 · see citing works
Tumor targeted siRNA delivery by adenosine receptor-specific curdlan nanoparticles
Bao, Q., Ganbold, T., Bao, M., Xiao, H. T., Han, S., & Baigude, H. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126845 · Cited by 9 · see citing works
Liu, J., Zhao, L., Sun, Y., Fu, Q., & Xiao, W. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102186 · Cited by 9 · see citing works
Yang, J., Kato, R., & Choi, J. H. (2025) · Nanoscale · doi:10.1039/d5nr01067e · Cited by 8 · see citing works
Sarhan, O. M., Gebril, M. I., & Elsegaie, D. (2025) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgaf113 · Cited by 8 · see citing works
Yan, S., Dong, L., Hu, Z., Zhang, Y., Xu, W. J., Xing, J., & Zhang, J. (2023) · Molecules · doi:10.3390/molecules28155874 · Cited by 8 · see citing works
Yang, G., Zhang, X., Zhou, S. D., Zhou, W. J., Yin, C., Xie, C., Fan, Q., & Huang, W. (2022) · Chemical Communications · doi:10.1039/d2cc01207c · Cited by 8 · see citing works
Peng, C., Li, J., Wang, N., Zhang, X., Zhang, W., Li, Z., Zhang, K., Ji, Y., He, W., & Li, Y. (2025) · Materials Horizons · doi:10.1039/d5mh01047k · Cited by 7 · see citing works
Functionalized albumin nanoparticles: A multifunctional platform for enhanced brain drug delivery
Mohammad, H., Darwish, M., Katona, G., & Csóka, I. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102616 · Cited by 7 · see citing works
Delivery of cisplatin and resiquimod in nanomicelles for the chemoimmunotherapy of ovarian cancer
Yin, W., & Qian, S. (2022) · Cancer Nanotechnology · doi:10.1186/s12645-021-00094-8 · Cited by 7 · see citing works
Asgharzadeh, F., Binabaj, M. M., Fanoudi, S., Cho, W. C. S., Yang, Y.-J., Azarian, M., Ardestani, M. S., Nasiri, N., Farani, M. R., & Huh, Y. S. (2024) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2024.061 · Cited by 7 · see citing works
Feng, Z., Yao, Y., Wang, Z., Xiang, X., Wang, L., Xiao, X., Tang, Y., Hu, W. W., Li, Q., & Qian, Z. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123450 · Cited by 7 · see citing works
Kumar, S., Rathaur, S., Maity, D., Varshney, P., & Gayen, J. R. (2026) · Nanomedicine · doi:10.1080/17435889.2026.2637591 · Cited by 6 · see citing works
Shi, C., Liu, B., Lu, F., Wei, B., Yu, S., & Chen, P. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115293 · Cited by 6 · see citing works
Yang, L., Huang, Y., Liu, C., Wang, Y., Wang, H., Yan, F., & Su, Z. (2025) · Small · doi:10.1002/smll.202506711 · Cited by 5 · see citing works
Induced Vascular Normalization—Can One Force Tumors to Surrender to a Better Microenvironment?
Sun, X., Nosrati, Z., Ko, J., Lee, C.-M., Bennewith, K. L., & Bally, M. B. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082022 · Cited by 5 · see citing works
Ngo, H. V., Nguyen, H. D., & Lee, B. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144168 · Cited by 6 · see citing works
Polymer Conjugate as the New Promising Drug Delivery System for Combination Therapy against Cancer
Hu, Q., Zhang, Y., Mukerabigwi, J. F., Wang, H., & Cao, Y. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266280603240321064308 · Cited by 5 · see citing works
Nabiyi, S., Heiat, M., & Rezaei, E. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.12.006 · Cited by 4 · see citing works
Alawi, M., Raahim, M., Kumar, M., Chin, K. K., Aramwit, P., & Mahmood, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s573137 · Cited by 4 · see citing works
Makaev, S. V., Badenhorst, R., Reukov, V. V., & Minko, S. (2023) · ACS symposium series · doi:10.1021/bk-2023-1457.ch008 · Cited by 4 · see citing works
- Authors
- Huang, D., Sun, L., Huang, L., & Chen, Y.
- Affiliations
- East China University of Science and Technology (CN)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Chen, Yanzuo
- Venue
- Journal of Personalized Medicine
- Publisher
- MDPI AG
- Published
- 2021-02-14
- Volume
- 11
- Issue
- 2
- Pages
- 124
- ISSN
- 2075-4426 (ISSN-L)
- PMC
- PMC7917988
- OpenAlex
- W3131567129
- Cited by
- 176
- References
- 199
- Citations by year
- 2026: 37 · 2025: 43 · 2024: 30 · 2023: 26 · 2022: 31 · 2021: 9
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Personalized Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UNC Libraries
- Funders
- Carolina Center of Cancer Nanotechnology Excellence, University of North Carolina - Chapel Hill (NIH grant CA198999)
- Natural Science Foundation of Shanghai (19ZR1472500)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- nanoparticle drug delivery, enhanced permeability and retention effect, tumor vasculature, tumor angiogenesis, vascular permeability, nanoparticle extravasation, liposomes, micelles, polymeric nanoparticles, cancer therapy, vascular occlusion
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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