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Cited by 152Pomegranate: compositions and health benefitsPhytochemicals and Antioxidant ActivitiesPhytochemistry and Bioactivity Studies

Pomegranate Peel Phytochemistry, Pharmacological Properties, Methods of Extraction, and Its Application: A Comprehensive Review

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Singh, Jyoti, Kaur, Hamita Preet, Verma, Anjali, Chahal, Arshminder Singh, Jajoria, Kaushal, Rasane, Prasad, Kaur, Sawinder, Kaur, Jaspreet +7 more·2023·ACS Omega
DOI 10.1021/acsomega.3c02586PMC PMC10551920
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Abstract

. (pomegranate), has traditionally been considered agricultural waste. However, recent studies have revealed its potential as a rich source of bioactive compounds with diverse pharmacological effects. Pomegranate peel is a rich reservoir of antioxidants, polyphenols, dietary fiber, and vitamins, which contribute to its remarkable bioactivity. Studies have demonstrated the anti-inflammatory, cardioprotective, wound healing, anticancer, and antimicrobial properties of pomegranate peel owing to the presence of phytochemicals, such as gallic acid, ellagic acid, and punicalagin. The extraction of bioactive compounds from pomegranate peel requires a careful selection of techniques to maximize the yield and quality. Green extraction methods, including pressurized liquid extraction (PLE), ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and enzyme-assisted extraction (EAE), offer efficient and sustainable alternatives to traditional methods. Furthermore, pomegranate peel has been utilized in the food industry, where it can significantly enhance the nutritional value, organoleptic characteristics, and shelf life of food products. Pomegranate peel has the potential to be used to develop innovative functional foods, nutraceuticals, and other value-added products, providing new opportunities for the pharmaceutical, cosmetic, and food industries.

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  • Pomegranate peel is useful in a variety of products like chicken patties, cakes, muffins, biscuits, curd, fermented milk beverage, pasta, and edible oil.

    “Pomegranate peel is useful in a variety of products like chicken patties, cakes, muffins, biscuits, curd, fermented milk beverage, pasta, and edible oil (Singh et al., 2023).”

    From Valorization of Pomegranate and Banana By-products into Value-added Products: Influence on Physicochemical, Rheological, and Consumer Attributes (2025) · cites this paper as Singh et al., 2023

    The Food Applications section lists muffins, cakes, biscuits, curd, fermented milk beverages, and edible oils among formulations using pomegranate peel; Table 4 also includes chicken meat patties. The review does not identify pasta as an application, so that item in the citing sentence is unsupported. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Strong antioxidant activities of these polyphenols are needed to enhance the life of living organisms by combating oxidative stress and preventing chronic diseases including cardiovascular disorders and cancer.

    “Strong antioxidant activities of these polyphenols are needed to enhance the life of living organisms by combating oxidative stress and preventing chronic diseases including cardiovascular disorders and cancer (Singh et al., 2023).”

    From Valorization of Pomegranate and Banana By-products into Value-added Products: Influence on Physicochemical, Rheological, and Consumer Attributes (2025) · cites this paper as Singh et al., 2023

    The Cardio-protective Properties section (page unavailable) describes pomegranate-peel polyphenols as antioxidants with potential to reduce cardiovascular risk factors, while the Anticancer Properties section (page unavailable) reports effects in cancer cells. These passages do not establish that the polyphenols extend organisms’ lives or prevent cardiovascular disease and cancer in living organisms; the claim presents those potential benefits as established outcomes. (LLM, conf=0.87)

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Cited by

Sorted by citations

Authors
Singh, J., Kaur, H. P., Verma, A., Chahal, A. S., Jajoria, K., Rasane, P., Kaur, S., Kaur, J., Gunjal, M., Ercisli, S., Choudhary, R., Bozhuyuk, M. R., Sakar, E., Karatas, N., & Durul, M. S.
Affiliations
  • Lovely Professional University (IN)
  • Department of Horticulture, Faculty of Agriculture, Ataturk University, 25240 Erzurum, Türkiye
  • Indian Agricultural Research Institute (IN)
  • Department of Horticulture, Faculty of Agriculture, Igdir University, 76100 Igdir, Türkiye
  • Harran University (TR)
  • Department of Nutrition and Dietetics, Faculty of Health Sciences, Ataturk University, 25240 Erzurum, Türkiye
  • Department of Horticulture, Faculty of Agriculture, Kocaeli University, 41380 Kocaeli, Türkiye
Corresponding author
Singh, Jyoti
ORCID
Venue
ACS Omega
Publisher
American Chemical Society (ACS)
Published
2023-09-19
Volume
8
Issue
39
Pages
35452-35469
ISSN
2470-1343 (ISSN-L)
DOI
10.1021/acsomega.3c02586
PMC
PMC10551920
OpenAlex
W4386864695
Cited by
152
References
5
Citations by year
2026: 59 · 2025: 56 · 2024: 35 · 2023: 2
FWCI
5.49
Type
journal article
Language
en
Open access
Licence
Locations
  • ACS Omega (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Lovely Professional University
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Phytochemistry and Bioactivity Studies
Keywords
pomegranate peel, Punica granatum, phytochemicals, polyphenols, antioxidants, gallic acid, ellagic acid, punicalagin, green extraction, accelerated solvent extraction, ultrasound-assisted extraction, microwave-assisted extraction, enzymatic extraction, anti-inflammatory activity, cardioprotective activity, wound healing, anticancer activity, antimicrobial activity, functional foods, nutraceuticals, agricultural waste valorization

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