Nitric Oxide-Releasing Electrospun Polymer Microfibers
Open accessAbstract
The preparation of electrospun polymer microfibers with nitric oxide (NO)-release capabilities is described. Polymer solutions containing disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), a low-molecular-weight NO donor, were electrospun to generate fibers ranging from 100-3000 nm in diameter capable of releasing NO upon immersion in aqueous solutions under physiological conditions (pH 7.4, 37 °C), with kinetics depending on polymer composition and fiber diameter. The NO release half-life for PROLI/NO-doped electrospun fibers was 2-200 times longer than that of PROLI/NO alone. The influence of polymer concentration, applied voltage, capillary diameter, solution conductivity, flow rate, and additives on fiber properties are reported and discussed with respect to potential applications.
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- Authors
- Coneski, P. N., Nash, J. A., & Schoenfisch, M. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Schoenfisch, Mark H.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-01-20
- Volume
- 3
- Issue
- 2
- Pages
- 426-432
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- PMC
- PMC3045468
- OpenAlex
- W2034862707
- Cited by
- 47
- References
- 28
- Citations by year
- 2023: 2 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 7 · 2012: 5
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (EB 000708, R01EB000708)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- nitric oxide release, nitric oxide donors, controlled drug release, fiber diameter, release kinetics, electrospinning parameters, capillary diameter, solution conductivity, polymer concentration
- MeSH terms
- Microscopy, Electron, Scanning, Nitric Oxide, Particle Size, Proline, Nitric Oxide Donors, Electrochemical Techniques, Nanofibers
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