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Surface Coating of Graphene Quantum Dots Using Mussel-Inspired Polydopamine for Biomedical Optical Imaging

Nurunnabi, Md, Khatun, Zehedina, Nafiujjaman, Md, Lee, Dong-geun, Lee, Yong-kyu·2013·ACS Applied Materials & Interfaces

Abstract

Because of the superiority of GQDs (graphene quantum dots) in biomedical imaging, in terms of biocompatibility and toxicity of semiconductor quantum dots, GQDs bring new opportunities for the diagnosis and detection of diseases. In this study, we synthesized photoluminescent (PL) graphene quantum dots (GQDs) through a simple exfoliation and oxidation process, and then coated them with polydopamine (pDA) for enhanced stability in water and low toxicity in vivo. From the results, the GQDs coated with pDA showed an excellent stability of PL intensity. It showed that the PL intensity of noncoated GQDs in PBS solution rapidly decreased with time, resulting in a 45% reduction of the PL intensity for 14 days of incubation in PBS solution. After coating with polydopamine, PL intensities of polydopamine-coated GQDs was maintained more stably for 14 days compared with uncoated GQDs. We have observed the in vitro and in vivo biocompatibility of pDA-coated GQDs in nude mice. The overall observation revealed that pDA-coated GQDs could be used as a long-term optical imaging agent as well as a biocompatible drug carrier.

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Metadata

Authors
Nurunnabi, M., Khatun, Z., Nafiujjaman, M., Lee, D.-G., & Lee, Y.-K.
Venue
ACS Applied Materials & Interfaces
Published
2013-08-06
Volume
5
Issue
16
Pages
8246-8253
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
OpenAlex
W2331535231
Cited by
158
References
2
FWCI
7.70
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Surface Coating of Graphene Quantum Dots Using Mussel-Inspired Polydopamine for Biomedical Optical Imaging. https://app.cochat.ai/papers/10.1021/am4023863
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Nurunnabi, M., Khatun, Z., Nafiujjaman, M., Lee, D.-G., & Lee, Y.-K. (2013). Surface Coating of Graphene Quantum Dots Using Mussel-Inspired Polydopamine for Biomedical Optical Imaging. ACS Applied Materials & Interfaces. https://doi.org/10.1021/am4023863

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