Comparison of Synthetic High Density Lipoprotein (HDL) Contrast Agents for MR Imaging of Atherosclerosis
Open accessAbstract
Determining arterial macrophage expression is an important goal in the molecular imaging of atherosclerosis. Here, we compare the efficacy of two synthetic, high density lipoprotein (HDL) based contrast agents for magnetic resonance imaging (MRI) of macrophage burden. Each form of HDL was labeled with gadolinium and rhodamine to allow MRI and fluorescence microscopy. Either the 37 or 18 amino acid peptide replaced the apolipoprotein A-I in these agents, which were termed 37pA-Gd or 18A-Gd. The diameters of 37pA-Gd and 18A-Gd are 7.6 and 8.0 nm, respectively, while the longitudinal relaxivities are 9.8 and 10.0 (mM s)(-1). 37pA has better lipid binding properties. In vitro tests with J774A.1 macrophages proved the particles possessed the functionality of HDL by eliciting cholesterol efflux and were taken up in a receptor-like fashion by the cells. Both agents produced enhancements in atherosclerotic plaques of apolipoprotein E knockout mice of approximately 90% (n = 7 per agent) and are macrophage specific as evidenced by confocal microscopy on aortic sections. The half-lives of 37pA-Gd and 18A-Gd are 2.6 and 2.1 h, respectively. Despite the more favorable lipid interactions of 37pA, both agents gave similar, excellent contrast for the detection of atherosclerotic macrophages using MRI.
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HDL can be modified by incorporating contrast labels such as Gd3+ in the phospholipid coating, allowing imaging of macrophages within atherosclerotic plaques.
“HDL can be modified by incorporating contrast labels such as Gd3+ in the phospholipid coating. Such modifications allow the imaging of macrophages within atherosclerotic plaques136 (FIG. 5e).”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [136]
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Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880 · see citing works
From Vulnerable Plaque to Vulnerable Patient
Naghavi, M., Libby, P., Falk, E., Casscells, S. W., Litovsky, S. H., Rumberger, J. A., Badimón, J. J., Stefanadis, C., Moreno, P., Pasterkamp, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087481.55887.c9 · Cited by 2,686 · see citing works
Self-citationFrom Vulnerable Plaque to Vulnerable Patient
Naghavi, M., Libby, P., Falk, E., Casscells, S. W., Litovsky, S. H., Rumberger, J. A., Badimón, J. J., Stefanadis, C., Moreno, P., Pasterkamp, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087480.94275.97 · Cited by 2,270 · see citing works
Self-citationRudd, J. H. F., Warburton, E. A., Fryer, T. D., Jones, H. A., Clark, J. C., Antoun, N. M., Johnström, P., Davenport, A. P., Kirkpatrick, P. J., Arch, B. N., et al. (2002) · Circulation · doi:10.1161/01.cir.0000020548.60110.76 · Cited by 1,226 · see citing works
Ruehm, S. G., Corot, C., VOGT, P. R., Kolb, S., & Debatin, J. F. (2001) · Circulation · doi:10.1161/01.cir.103.3.415 · Cited by 600 · see citing works
Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis
Nahrendorf, M., Zhang, H., Hembrador, S., Panizzi, P., Sosnovik, D. E., Aikawa, E., Libby, P., Swirski, F. K., & Weissleder, R. (2008) · Circulation · doi:10.1161/circulationaha.107.741181 · Cited by 559 · see citing works
Imaging of atherosclerotic cardiovascular disease
Sanz, J., & Fayad, Z. A. (2008) · Nature · doi:10.1038/nature06803 · Cited by 558 · see citing works
Self-citationNoninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography
Hyafil, F., Cornily, J.-C., Feig, J. E., Gordon, R., Vucic, E., Amirbekian, V., Fisher, E. A., Fuster, V., Feldman, L. J., & Fayad, Z. A. (2007) · Nature Medicine · doi:10.1038/nm1571 · Cited by 467 · see citing works
Self-citationDetection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle
Kelly, K. A., Allport, J. R., Tsourkas, A., Patil, V. R. S., Josephson, L., & Weissleder, R. (2005) · Circulation Research · doi:10.1161/01.res.0000155722.17881.dd · Cited by 448 · see citing works
Amirbekian, V., Lipinski, M. J., Briley-Saebo, K. C., Amirbekian, S., Aguinaldo, J. G. S., Weinreb, D. B., Vucic, E., Frias, J. C., Hyafil, F., Mani, V., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606281104 · Cited by 356 · see citing works
Self-citationNanocrystal Core High-Density Lipoproteins: A Multimodality Contrast Agent Platform
Cormode, D. P., Skajaa, T., van Schooneveld, M. M., Koole, R., Jarzyna, P., Lobatto, M. E., Calcagno, C., Barazza, A., Gordon, R. E., Zanzonico, P., et al. (2008) · Nano Letters · doi:10.1021/nl801958b · Cited by 328 · see citing works
Self-citationMacrophage Uptake of Core−Shell Nanoparticles Surface Modified with Poly(ethylene glycol)
Zahr, A. S., Davis, C. A., & Pishko, M. V. (2006) · Langmuir · doi:10.1021/la060951b · Cited by 324 · see citing works
Anantharamaiah, G. M., Jones, J. L., Brouillette, C. G., Schmidt, C. F., Chung, B. H., Hughes, T. A., Bhown, A. S., & Segrest, J. P. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39238-4 · Cited by 316 · see citing works
Recombinant HDL-Like Nanoparticles: A Specific Contrast Agent for MRI of Atherosclerotic Plaques
Frias, J. C., Williams, K. J., Fisher, E. A. A., & Fayad, Z. A. (2004) · Journal of the American Chemical Society · doi:10.1021/ja044911a · Cited by 299 · see citing works
Self-citationMolecular, cellular and functional imaging of atherothrombosis
Choudhury, R. P., Fuster, V., & Fayad, Z. A. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1548 · Cited by 252 · see citing works
Self-citationMolecular Imaging of Cardiovascular Disease
Jaffer, F. A., Libby, P., & Weissleder, R. (2007) · Circulation · doi:10.1161/circulationaha.106.647164 · Cited by 217 · see citing works
Liu, J., Zeng, F., & Allen, C. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2006.11.010 · Cited by 183 · see citing works
Frias, J. C., Ma, Y., Williams, K. J., Fayad, Z. A., & Fisher, E. A. A. (2006) · Nano Letters · doi:10.1021/nl061498r · Cited by 164 · see citing works
Self-citationLipinski, M. J., Amirbekian, V., Frias, J. C., Aguinaldo, J. G. S., Mani, V., Briley-Saebo, K. C., Fuster, V., Fallon, J. T., Fisher, E. A. A., & Fayad, Z. A. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20995 · Cited by 151 · see citing works
Self-citationAortic Wall Mechanics and Composition in a Transgenic Mouse Model of Marfan Syndrome
Marque, V., Kieffer, P., Gayraud-Morel, B., Lartaud, I., Ramirez, F., & Atkinson, J. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0701.092136 · Cited by 132 · see citing works
Apolipoprotein A-I mimetic peptides and their role in atherosclerosis prevention
Navab, M., Anantharamaiah, G. M., Reddy, S. T., & Fogelman, A. M. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0661 · Cited by 131 · see citing works
Nikanjam, M., Blakely, E. A., Bjornstad, K. A., Shu, X., Budinger, T. F., & Forte, T. M. (2006) · eScholarship (California Digital Library) · Cited by 118 · see citing works
Cormode, D. P., Briley-Saebo, K. C., Mulder, W. J. M., Aguinaldo, J. G. S., Barazza, A., Ma, Y., Fisher, E. A. A., & Fayad, Z. A. (2008) · Small · doi:10.1002/smll.200701285 · Cited by 107 · see citing works
Self-citationHoffman, J. S., & Benditt, E. P. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110847 · Cited by 106 · see citing works
Tang, C., Vaughan, A. M., Anantharamaiah, G. M., & Oram, J. F. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500240-jlr200 · Cited by 82 · see citing works
Low Priority of Cardiovascular and Chronic Diseases on the Global Health Agenda
Fuster, V., Voûte, J., Hunn, M., & Smith, S. C. (2007) · Circulation · doi:10.1161/circulationaha.107.733444 · Cited by 81 · see citing works
Davidson, W. S., Lund‐Katz, S., Johnson, W. J., Anantharamaiah, G. M., Palgunachari, M. N., Segrest, J. P., Rothblat, G. H., & Phillips, M. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31606-x · Cited by 74 · see citing works
Bocharov, A. V., Baranova, I. N., Vishnyakova, T. G., Remaley, A. T., Csákó, G., Fairwell, T., Patterson, A. P., & Eggerman, T. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314264200 · Cited by 70 · see citing works
Magnetic resonance imaging of atherosclerosis
Leiner, T., Gerretsen, S. C., Botnar, R. M., Lutgens, E., Cappendijk, V. C., Kooi, M. E., & van Engelshoven, J. M. A. (2005) · European Radiology · doi:10.1007/s00330-005-2646-8 · Cited by 63 · see citing works
Magnetic resonance and fluorescence based molecular imaging technologies
Sosnovik, D. E., & Weissleder, R. (2005) · Birkhäuser Basel eBooks · doi:10.1007/3-7643-7426-8_3 · Cited by 36 · see citing works
Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme
Nikanjam, M., Blakely, E. A., Bjornstad, K. A., et al. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.07.046 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Atherosclerotic Plaque Composition: Analysis with Multicolor CT and Targeted Gold Nanoparticles
Cormode, D. P., Roessl, E., Thran, A., Skajaa, T., Gordon, R. E., Schlomka, J.-P., Fuster, V., Fisher, E. A., Mulder, W. J. M., Proksa, R., et al. (2010) · Radiology · doi:10.1148/radiol.10092473 · Cited by 479 · see citing works
Self-citationPerspectives and opportunities for nanomedicine in the management of atherosclerosis
Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works
Self-citationModified natural nanoparticles as contrast agents for medical imaging
Cormode, D. P., Jarzyna, P. A., Mulder, W. J. M., & Fayad, Z. A. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.005 · Cited by 197 · see citing works
Self-citationLipoproteins and lipoprotein mimetics for imaging and drug delivery
Thaxton, C. S., Rink, J. S., Naha, P. C., & Cormode, D. P. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.020 · Cited by 137 · see citing works
Self-citationDetection and treatment of atherosclerosis using nanoparticles
Zhang, J., Zu, Y., Dhanasekara, C. S., Li, J., Wu, D., Fan, Z., & Wang, S. F. (2016) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1412 · Cited by 131 · see citing works
Ng, K. K., Lovell, J. F., Vedadi, A., Hajian, T., & Zheng, G. (2013) · ACS Nano · doi:10.1021/nn400418y · Cited by 127 · see citing works
Kim, Y., Fay, F., Cormode, D. P., Sánchez-Gaytán, B. L., Tang, J., Hennessy, E. J., Ma, M., Moore, K. J., Farokhzad, O. C., Fisher, E. A. A., et al. (2013) · ACS Nano · doi:10.1021/nn4039063 · Cited by 123 · see citing works
Self-citationTemplated high density lipoprotein nanoparticles as potential therapies and for molecular delivery
Damiano, M. G., Mutharasan, R. K., Tripathy, S., McMahon, K. M., & Thaxton, C. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.013 · Cited by 117 · see citing works
High-Density Lipoprotein–Based Contrast Agents for Multimodal Imaging of Atherosclerosis
Skajaa, T., Cormode, D. P., Falk, E., Mulder, W. J. M., Fisher, E. A. A., & Fayad, Z. A. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179275 · Cited by 115 · see citing works
Self-citationNanoparticle-based drug delivery: case studies for cancer and cardiovascular applications
Galvin, P., Thompson, D., Ryan, K. B., McCarthy, A., Moore, A., Burke, C. S., Dyson, M. A., MacCraith, B. D., Gun’ko, Y. K., Byrne, M. T., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0856-6 · Cited by 114 · see citing works
van Tilborg, G. A. F., Vucic, E., Strijkers, G. J., Cormode, D. P., Mani, V., Skajaa, T., Reutelingsperger, C. P. M., Fayad, Z. A., Mulder, W. J. M., & Nicolay, K. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100091q · Cited by 108 · see citing works
Self-citationStructure and Function of HDL Mimetics
Navab, M., Shechter, I., Anantharamaiah, G. M., Reddy, S. T., Lenten, B. J. V., & Fogelman, A. M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.187518 · Cited by 104 · see citing works
In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models
Pérez‐Medina, C., Binderup, T., Lobatto, M. E., Tang, J., Calcagno, C., Giesen, L., Wessel, C. H., Witjes, J. J., Ishino, S., Baxter, S., et al. (2016) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2016.01.020 · Cited by 102 · see citing works
Self-citationFischer, N. O., Rasley, A., Corzett, M., Hwang, M. H., Hoeprich, P. D., & Blanchette, C. (2013) · Journal of the American Chemical Society · doi:10.1021/ja3063293 · Cited by 96 · see citing works
High-Density Lipoprotein Nanobiologics for Precision Medicine
Mulder, W. J. M., van Leent, M. M. T., Lameijer, M., Fisher, E. A. A., Fayad, Z. A., & Pérez‐Medina, C. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00339 · Cited by 86 · see citing works
Self-citationBoekhorst, B. C. M. T., Bovens, S. M., Hellings, W. E., van der Kraak, P. H., van de Kolk, K. W. A., Vink, A., Moll, F. L., van Oosterhout, M. F. M., de Vries, J. P., Doevendans, P. A., et al. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq340 · Cited by 81 · see citing works
BIOMEDICAL APPLICATIONS OF MAGNETIC NANOPARTICLES
Wu, A., OU, P., & Zeng, L. (2010) · NANO · doi:10.1142/s1793292010002165 · Cited by 75 · see citing works
Design and development of quantum dots and other nanoparticles based cellular imaging probe
Jana, N. R. (2010) · Physical Chemistry Chemical Physics · doi:10.1039/c0cp00726a · Cited by 74 · see citing works
Nanoparticles as magnetic resonance imaging contrast agents for vascular and cardiac diseases
Chen, W., Cormode, D. P., Fayad, Z. A., & Mulder, W. J. M. (2010) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.114 · Cited by 68 · see citing works
Self-citationThe choice of targets and ligands for site-specific delivery of nanomedicine to atherosclerosis
Zia, A., Wu, Y., Nguyen, T. A. H., Wang, X., Peter, K., & Ta, H. T. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa047 · Cited by 60 · see citing works
High density lipoprotein mimicking nanoparticles for atherosclerosis
Chen, J., Zhang, X., Millican, R. C., Creutzmann, J. E., Martin, S., & Jun, H. (2020) · Nano Convergence · doi:10.1186/s40580-019-0214-1 · Cited by 57 · see citing works
Targeting and therapeutic peptides in nanomedicine for atherosclerosis
Chung, E. J. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216640940 · Cited by 56 · see citing works
Nandwana, V., Ryoo, S., Kanthala, S., McMahon, K. M., Rink, J. S., Li, Y., Venkatraman, S. S., Thaxton, C. S., & Dravid, V. P. (2017) · Chemistry of Materials · doi:10.1021/acs.chemmater.6b05357 · Cited by 54 · see citing works
Artificial High Density Lipoprotein Nanoparticles in Cardiovascular Research
Kornmueller, K., Vidaković, I., & Prassl, R. (2019) · Molecules · doi:10.3390/molecules24152829 · Cited by 48 · see citing works
Cormode, D. P., Skajaa, T., Delshad, A., Parker, N., Jarzyna, P. A., Calcagno, C., Galper, M. W., Skajaa, T., Briley-Saebo, K. C., Bell, H. M., et al. (2011) · Bioconjugate Chemistry · doi:10.1021/bc1003179 · Cited by 42 · see citing works
Self-citationHDL as a contrast agent for medical imaging
Cormode, D. P., Frias, J. C., Ma, Y., Chen, W., Skajaa, T., Briley-Saebo, K. C., Barazza, A., Williams, K. J., Mulder, W. J. M., Fayad, Z. A., et al. (2009) · Clinical Lipidology · doi:10.2217/clp.09.38 · Cited by 41 · see citing works
Self-citationFischer, N. O., Infante, E., Ishikawa, T., Blanchette, C., Bourne, N., Hoeprich, P. D., & Mason, P. W. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100083d · Cited by 39 · see citing works
Weilhammer, D. R., Blanchette, C., Fischer, N. O., Alam, S., Loots, G. G., Corzett, M., Thomas, C. B., Lychak, C., Dunkle, A. D., Ruitenberg, J. J., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.038 · Cited by 36 · see citing works
Valkenburgh, J. S. V., Meuret, C. J., Martinez, A. E., Kodancha, V., Solomon, V. A., Chen, K., & Yassine, H. N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.700847 · Cited by 36 · see citing works
LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models
Yamakoshi, Y. N., Qiao, H., Lowell, A. N., Woods, M., Paulose, B. J., Nakao, Y., Zhang, H., Liu, T., Lund‐Katz, S., & Zhou, R. (2011) · Chemical Communications · doi:10.1039/c1cc10924c · Cited by 30 · see citing works
Gadolinium-Based Contrast Agents for Vessel Wall Magnetic Resonance Imaging (MRI) of Atherosclerosis
Calcagno, C., Ramachandran, S., Millon, A., Robson, P. M., Mani, V., & Fayad, Z. A. (2012) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-012-9177-x · Cited by 30 · see citing works
Self-citationSingh, A., Nandwana, V., Rink, J. S., Ryoo, S., Chen, T. H., Allen, S. D., Scott, E. A., Gordon, L. I., Thaxton, C. S., & Dravid, V. P. (2019) · ACS Nano · doi:10.1021/acsnano.9b03727 · Cited by 25 · see citing works
Debbage, P. L., & Thurner, G. C. (2010) · Pharmaceuticals · doi:10.3390/ph3113371 · Cited by 22 · see citing works
Rui, M., Xu, J., Xu, Y., Guo, Ding, Q., & Wei, X. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s33139 · Cited by 24 · see citing works
A systematic review of the biodistribution of biomimetic high-density lipoproteins in mice
Pedersbæk, D., & Simonsen, J. B. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.038 · Cited by 23 · see citing works
LDL-mimetic lipid nanoparticles prepared by surface KAT ligation for in vivo MRI of atherosclerosis
Fracassi, A., Cao, J., Yoshizawa-Sugata, N., Tóth, É., Archer, C., Gröninger, O. G., Ricciotti, E., Tang, S. Y., Handschin, S., Bourgeois, J., et al. (2020) · Chemical Science · doi:10.1039/d0sc04106h · Cited by 21 · see citing works
Oriana, S., Fracassi, A., Archer, C., & Yamakoshi, Y. N. (2018) · Langmuir · doi:10.1021/acs.langmuir.8b01945 · Cited by 20 · see citing works
Phinikaridou, A., Andía, M. E., Shah, A. M., & Botnar, R. M. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00583.2012 · Cited by 16 · see citing works
Nanoengineering Apolipoprotein A1‐Based Immunotherapeutics
Schrijver, D. P., de Dreu, A., Hofstraat, S. R. J., Kluza, E., Zwolsman, R. C., Deckers, J., Anbergen, T., de Bruin, K., Trines, M. M., Nugraha, E. G., et al. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202100083 · Cited by 17 · see citing works
Self-citationLi, X., Wu, M., Li, J., Guo, Q., Zhao, Y., & Zhang, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.906512 · Cited by 16 · see citing works
Lowell, A. N., Qiao, H., Liu, T., Ishikawa, T., Zhang, H., Oriana, S., Wang, M., Ricciotti, E., FitzGerald, G. A., Zhou, R., et al. (2012) · Bioconjugate Chemistry · doi:10.1021/bc300561e · Cited by 16 · see citing works
Design of Nanovectors for Therapy and Imaging of Cardiovascular Diseases
Eniola‐Adefeso, O., Heslinga, M. J., & Porter, T. M. (2012) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcj-8-1-13 · Cited by 14 · see citing works
Rolla, G. A., Botta, M., Tei, L., Cabella, C., Ghiani, S., Brioschi, C., & Maiocchi, A. (2013) · Chemistry - A European Journal · doi:10.1002/chem.201301837 · Cited by 13 · see citing works
Yong-Sang, J., Dioury, F., Meneyrol, V., Aït-Arsa, I., Idoumbin, J.-P., Guibbal, F., Patché, J., Gimié, F., Khantalin, I., Couprie, J., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.05.002 · Cited by 12 · see citing works
Uribe, K. B., Benito‐Vicente, A., Martı́n, C., Blanco‐Vaca, F., & Rotllán, N. (2021) · Biomaterials Science · doi:10.1039/d0bm01838d · Cited by 11 · see citing works
The role of high‐density lipoproteins in antitumor drug delivery
Sarhadi, S., Ganjali, S., Pirro, M., & Sahebkar, A. (2019) · IUBMB Life · doi:10.1002/iub.2105 · Cited by 11 · see citing works
The growing interest of fibrin imaging in atherosclerosis
Clofent‐Sanchez, G., Jacobin‐Valat, M., & Laroche‐Traineau, J. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.01.041 · Cited by 11 · see citing works
Liu, X., Wang, W., Li, Q., Niu, H., & Zhang, W. (2024) · International Journal of Smart and Nano Materials · doi:10.1080/19475411.2024.2395270 · Cited by 9 · see citing works
He, J., Dai, Y., Xu, F., Huang, X., Gao, Y., Liu, L., Zhang, W., & Liu, J. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140826 · Cited by 7 · see citing works
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Fay, F., Sánchez-Gaytán, B. L., Cormode, D. P., Skajaa, T., Fisher, E. A. A., Fayad, Z. A., & Mulder, W. J. M. (2012) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-012-9181-1 · Cited by 7 · see citing works
Self-citationBoekhorst, B. C. M. T., Cramer, M. J., Pasterkamp, G., van Echteld, C. J. A., & Doevendans, P. A. (2010) · International journal of cardiac imaging · doi:10.1007/s10554-009-9566-7 · Cited by 7 · see citing works
Noninvasive Carotid Artery Imaging with a Focus on the Vulnerable Plaque
Young, V. E. L., Sadat, U., & Gillard, J. H. (2011) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2011.01.006 · Cited by 6 · see citing works
Advances in contrast media for vascular imaging of atherosclerosis
Young, V. E. L., Degnan, A. J., & Gillard, J. H. (2011) · Imaging in Medicine · doi:10.2217/iim.11.23 · Cited by 5 · see citing works
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McAteer, M. A., & Choudhury, R. P. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2929-0_4 · Cited by 5 · see citing works
Ramos‐Cabrer, P., Fay, F., Sánchez-Gaytán, B. L., Tang, J., Castillo, J., Fayad, Z. A., & Mulder, W. J. M. (2016) · ACS Omega · doi:10.1021/acsomega.6b00108 · Cited by 4 · see citing works
Self-citationAtherosclerotic Plaque Imaging
Lavín, B., Gebhardt, P., Phinikaridou, A., & Botnar, R. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-53001-7_8 · Cited by 3 · see citing works
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Fracassi, A., Qiao, H., Lowell, A. N., Cao, J., Bode, J. W., Masai, H., Yoshizawa-Sugata, N., Zhou, R., & Yamakoshi, Y. N. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00667 · Cited by 3 · see citing works
Lipid-Based Nanoparticles in Cardiovascular Molecular Imaging
Crich, S. G., Alberti, D., Orio, L., Stefanìa, R., Longo, D. L., & Aime, S. (2012) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-012-9180-2 · Cited by 2 · see citing works
Malytskyi, V., Moreau, J., Callewaert, M., Rigaux, G., Cadiou, C., Laurent, S., & Chuburu, F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-818433-2.00013-3 · Cited by 2 · see citing works
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Călin, M., Butoi, E. D., Manea, S., Simionescu, M., & Manea, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-34193-4_17 · Cited by 2 · see citing works
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Bonnet, C. S., & Tóth, É. (2012) · Supramolecular chemistry · doi:10.1002/9780470661345.smc104 · Cited by 2 · see citing works
Quantum Dots and Doped Nanocrystals: Synthesis, Optical Properties, and Bio-applications
Zhao, Y. (2013) · Utrecht University Repository (Utrecht University) · doi:10.13140/rg.2.2.32338.15047 · Cited by 2 · see citing works
Molecular MRI of Atherosclerosis
Te, B. C., & Nicolay, K. (2012) · InTech eBooks · doi:10.5772/31550 · Cited by 1 · see citing works
MRI of atherosclerosis: from mouse to man
Phinikaridou, A., & Botnar, R. M. (2012) · Imaging in Medicine · doi:10.2217/iim.11.75 · Cited by 1 · see citing works
Molecular MRI of Atherosclerosis
Young, V. E. L., Tang, T. Y., Sadat, U., & Gillard, J. H. (2010) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-010-9006-z · Cited by 1 · see citing works
Fabrication of Spheroidal Microparticles from Biodegradable Polymers for Drug Delivery Applications
Heslinga, M. J. (2012) · Cited by 1 · see citing works
Enhancement of HDL Formation and Normalization of Intravascular HDL Remodeling
Kontush, A., & Chapman, M. J. (2011) · Wiley eBooks · doi:10.1002/9781118158678.ch11
Nanotechnology Applications in Cardiology
Malhotra, A. (2014) · Advances in chemical and materials engineering book series · doi:10.4018/978-1-4666-6363-3.ch007
Investigation of Porphyrin and Lipid Supramolecular Assemblies for Cancer Imaging and Therapy
Ng, K. K. (2015) · TSpace (University of Toronto)
Current Awareness in NMR in Biomedicine
(2010) · NMR in Biomedicine · doi:10.1002/nbm.1449
Current Awareness in Contrast Media and Molecular Imaging
(2009) · Contrast Media & Molecular Imaging · doi:10.1002/cmmi.249
Nanotechnology Applications in Cardiology
Malhotra, A. (2016) · IGI Global eBooks · doi:10.4018/978-1-5225-0571-6.ch034
- Authors
- Cormode, D. P., Chandrasekar, R., Delshad, A., Briley-Saebo, K. C., Calcagno, C., Barazza, A., Mulder, W. J. M., Fisher, E. A., & Fayad, Z. A.
- Affiliations
- New York University (US)
- Corresponding author
- Fisher, Edward A.
- Fayad, Zahi A.
- ORCID
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-04-20
- Volume
- 20
- Issue
- 5
- Pages
- 937-943
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- PMC
- PMC2765543
- OpenAlex
- W2039685011
- Cited by
- 72
- References
- 31
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 3 · 2016: 7 · 2015: 2 · 2014: 1 · 2013: 6 · 2012: 13
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Bioconjugate Chemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Technische Universiteit Eindhoven
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL78667, R01HL078667, R0I HL71021, R01HL071021)
- National Cancer Institute (R24CA095823)
- National Center for Research Resources (1 S10RR0 9145-01)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- atherosclerosis, macrophage imaging, gadolinium-based contrast agents, apolipoprotein A-I mimetic, atherosclerotic plaque, ApoE-deficient mice, cholesterol efflux, receptor-mediated uptake, molecular imaging, relaxivity, tissue distribution
- MeSH terms
- Amino Acid Sequence, Animals, Biological Transport, Cell Line, Cholesterol, Contrast Media, Lipoproteins, HDL, Macrophages, Magnetic Resonance Imaging, Male, Molecular Sequence Data, Peptides, Microscopy, Confocal, Atherosclerosis, Mice, Rats
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