The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
DNA Nanoparticles and Development of DNA Delivery Vehicles for Gene Therapy
Abstract
DNA transport through the cell membrane is an essential requirement for gene therapy, which utilizes oligonucleotides and plasmid DNA. However, membrane transport of DNA is an inefficient process, and the mechanism(s) by which this process occurs is not clear. Although viral vectors are effective in gene therapy, the immune response elicited by viral proteins poses a major problem. Therefore, several laboratories are involved in the development of nonviral DNA delivery vehicles. These vehicles include polyamines, polycationic lipids, and neutral polymers, capable of condensing DNA to nanoparticles with radii of 20-100 nm. Although the structural and energetic forces involved in DNA condensation have been studied by physical biochemists for the past 25 years, this area has experienced a resurgence of interest in recent years because of the influx of biotechnologists involved in developing gene therapy protocols to combat a variety of human diseases. Despite an intense effort to study the mechanism(s) of DNA condensation using a variety of microscopic, light scattering, fluorescence, and calorimetric techniques, the precise details of the energetics of DNA nanoparticle formation and their packing assembly are not known at present. Future studies aimed at defining the mechanism(s) of DNA compaction and structural features of DNA nanoparticles might aid in the development of novel gene delivery vehicles.
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Cites
Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid
Zabner, J., Fasbender, A. J., Moninger, T., Poellinger, K. A., & Welsh, M. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18997 · Cited by 1,410
An Inverted Hexagonal Phase of Cationic Liposome-DNA Complexes Related to DNA Release and Delivery
Koltover, I., Salditt, T., Rädler, J. O., & Safinya, C. R. (1998) · Science · doi:10.1126/science.281.5373.78 · Cited by 1,334
Poly(ethylenimine) and its role in gene delivery
Godbey, W. T., Wu, K. K., & Mikos, A. G. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00090-5 · Cited by 1,199
Zanta, M. A., Belguise-Valladier, P., & Behr, J.-P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.1.91 · Cited by 722
Pollard, H., Remy, J.-S., Loussouarn, G., Demolombe, S., Behr, J.-P., & Escande, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7507 · Cited by 711
Different behavior of branched and linear polyethylenimine for gene deliveryin vitro andin vivo
Wightman, L., Kircheis, R., R�ssler, V., Carotta, S., Ruzicka, R., Kursa, M., & Wagner, E. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.187 · Cited by 697
Cation-induced toroidal condensation of DNA
Widom, J., & Baldwin, R. L. (1980) · Journal of Molecular Biology · doi:10.1016/0022-2836(80)90330-7 · Cited by 552
Polylysine-based transfection systems utilizing receptor-mediated delivery
Zauner, W., Ogris, M., & Wagner, E. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00110-5 · Cited by 504
Zhou, X., & Huang, L. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90066-3 · Cited by 495
Sternberg, B., Sorgi, F. L., & Huang, L. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01315-2 · Cited by 428
The Structure of DNA−Liposome Complexes
Lasic, D. D., Strey, H., Stuart, M. C. A., Podgornik, R., & Frederik, P. M. (1997) · Journal of the American Chemical Society · doi:10.1021/ja962713g · Cited by 377
DNA Aggregation Induced by Polyamines and Cobalthexamine
Pelta, J., Livolant, F., & Sikorav, J.-L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5656 · Cited by 364
Böttcher, C., Endisch, C., Fuhrhop, J.-H., Catterall, C., & Eaton, M. (1998) · Journal of the American Chemical Society · doi:10.1021/ja971047w · Cited by 250
Matulis, D., Rouzina, I., & Bloomfield, V. A. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3470 · Cited by 249
Brunner, S., Fürtbauer, E., Sauer, T., Kursa, M., & Wagner, E. (2002) · Molecular Therapy · doi:10.1006/mthe.2001.0509 · Cited by 244
Matulis, D., Rouzina, I., & Bloomfield, V. A. (2002) · Journal of the American Chemical Society · doi:10.1021/ja0124055 · Cited by 236
Lavigne, J. J., Savoy, S., Clevenger, M. B., Ritchie, J. E., McDoniel, B., Yoo, S.-J., Anslyn, E. V., McDevitt, J. T., Shear, J. B., & Neikirk, D. (1998) · Journal of the American Chemical Society · doi:10.1021/ja9743405 · Cited by 230
ZUBER, G. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00213-7 · Cited by 215
X-ray diffraction studies on cation-collapsed DNA
Schellman, J. A., & Parthasarathy, N. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90351-6 · Cited by 182
Dauty, E., Remy, J.-S., Blessing, T., & Behr, J.-P. (2001) · Journal of the American Chemical Society · doi:10.1021/ja015867r · Cited by 181
Rational Approaches to the Design of Cationic Gemini Surfactants for Gene Delivery
McGregor, C., Perrin, C., Monck, M., Camilleri, P., & Kirby, A. J. (2001) · Journal of the American Chemical Society · doi:10.1021/ja005681c · Cited by 177
Simple Simulations of DNA Condensation
Stevens, M. J. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76000-6 · Cited by 177
Major limitations in the use of cationic liposomes for DNA delivery
Filion, M. C., & Phillips, N. C. (1998) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)00423-7 · Cited by 155
Lipoplex Formation under Equilibrium Conditions Reveals a Three-Step Mechanism
Oberle, V., Bakowsky, U., Zuhorn, I. S., & Hoekstra, D. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76396-x · Cited by 135
Geall, A. J., Eaton, M. A. W., BAKER, T. S., Catterall, C. F., & Blagbrough, I. S. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01262-4 · Cited by 70
Yoshikawa, Y., & Yoshikawa, K. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00190-k · Cited by 69
Pichon, C., Cam, É. L., Guérin, B., Coulaud, D., Delain, E., & Midoux, P. (2001) · Bioconjugate Chemistry · doi:10.1021/bc015503o · Cited by 66
Ramsay, E., & Gumbleton, M. (2002) · Journal of drug targeting · doi:10.1080/10611860290007487 · Cited by 63
Signal transduction as a drug-discovery platform
(2000) · Nature Biotechnology · doi:10.1038/80076 · Cited by 47
Junghans, M., Kreuter, J., & Zimmer, A. (2001) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00219-3 · Cited by 43
Cited by
Natural Polymers for Gene Delivery and Tissue Engineering
DANG, J., & LEONG, K. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.03.001 · Cited by 694
Cellular responses to nanoparticles: Target structures and mechanisms
Unfried, K., Albrecht, C., Klotz, L.-O., Von Mikecz, A., Grether-Beck, S., & Schins, R. P. F. (2007) · Nanotoxicology · doi:10.1080/00222930701314932 · Cited by 503
CHEN, M., & VONMIKECZ, A. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.12.021 · Cited by 493
Sol-Gel processing of silica nanoparticles and their applications
Singh, L. P., Bhattacharyya, S. K., Kumar, R., Mishra, G., Sharma, U., Singh, G., & Ahalawat, S. (2014) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2014.10.007 · Cited by 428
Entropy and enthalpy of polyelectrolyte complexation: Langevin dynamics simulations
Ou, Z., & Muthukumar, M. (2006) · The Journal of Chemical Physics · doi:10.1063/1.2178803 · Cited by 351
Metadata
- Authors
- Vijayanathan, V., Thomas, T., & Thomas, T. J.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-10-19
- Volume
- 41
- Issue
- 48
- Pages
- 14085-14094
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2051149972
- Cited by
- 360
- References
- 30
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- closed
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