An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works

Large-scale characterization of HeLa cell nuclear phosphoproteins

Beausoleil, S. A., Jedrychowski, M. P., Schwartz, D., Elias, J. E., Villén, J., Li, J., Cohn, M. A., Cantley, L. C., & Gygi, S. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404720101 · Cited by 1,376 · see citing works

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

Gerhart‐Hines, Z., Rodgers, J. T., Bare, O., Lerin, C., Kim, S., Mostoslavsky, R., Alt, F. W., Wu, Z., & Puigserver, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601633 · Cited by 1,294 · see citing works

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

Purushotham, A., Schug, T. T., Xu, Q., Surapureddi, S., Guo, X., & Li, X. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.006 · Cited by 1,112 · see citing works

Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications

Yang, X.-J., & Seto, E. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.07.002 · Cited by 1,006 · see citing works

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

Lan, F., Cacicedo, J. M., Ruderman, N., & Ido, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805711200 · Cited by 825 · see citing works

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

Hou, X., Xu, S., Maitland-Toolan, K. A., Sato, K., Jiang, B., Ido, Y., Lan, F., Walsh, K., Wierzbicki, M., Verbeuren, T. J., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802187200 · Cited by 778 · see citing works

Large-scale phosphorylation analysis of mouse liver

Villén, J., Beausoleil, S. A., Gerber, S. A., & Gygi, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609836104 · Cited by 730 · see citing works

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

Feige, J. N., Lagouge, M., Canto, C., Strehle, A., Houten, S. M., Milne, J. C., Lambert, P. D., Mataki, C., Elliott, P. J., & Auwerx, J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.017 · Cited by 719 · see citing works

The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis

Schreiber, S., Emter, R., Hock, M. B., Knutti, D., Cardenas, J., Podvinec, M., Oakeley, E. J., & Kralli, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308686101 · Cited by 657 · see citing works

SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR

Li, X., Zhang, S., Blander, G., Tse, J. G., Krieger, M., & Guarente, L. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.032 · Cited by 631 · see citing works

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

Giguère, V. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0017 · Cited by 584 · see citing works

Tissue-specific regulation of SIRT1 by calorie restriction

Chen, D., Bruno, J., Easlon, E., Lin, S.-J., Cheng, H.-L., Alt, F. W., & Guarente, L. (2008) · Genes & Development · doi:10.1101/gad.1650608 · Cited by 567 · see citing works

GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1α

Lerin, C., Rodgers, J. T., Kalume, D. E., Kim, S.-H., Pandey, A., & Puigserver, P. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.013 · Cited by 443 · see citing works

Genome-wide Orchestration of Cardiac Functions by the Orphan Nuclear Receptors ERRα and γ

Dufour, C. R., Wilson, B. J., Huss, J. M., Kelly, D. P., Alaynick, W. A., Downes, M., Evans, R. M., Blanchette, M., & Giguère, V. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.007 · Cited by 418 · see citing works

The histone acetylase PCAF is a nuclear receptor coactivatorPreprint

Blanco, J. C. G., Minucci, S., Lü, J., Yang, X., Walker, K. K., Chen, H., Evans, R. M., Nakatani, Y., & Ozato, K. (1998) · Genes & Development · doi:10.1101/gad.12.11.1638 · Cited by 388 · see citing works

The Orphan Nuclear Receptor Estrogen-Related Receptor α Is a Transcriptional Regulator of the Human Medium-Chain Acyl Coenzyme A Dehydrogenase Gene

SLADEK, R. M., Bader, J.-A., & Giguère, V. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5400 · Cited by 375 · see citing works

Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor α.

Luo, J., Sladek, R., Carrier, J., Bader, J.-A., Richard, D., & Giguère, V. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.7947-7956.2003 · Cited by 370 · see citing works

Direct Acetylation of the Estrogen Receptor α Hinge Region by p300 Regulates Transactivation and Hormone Sensitivity

Wang, C., Fu, M., Angeletti, R. H., Siconolfi-Baez, L., Reutens, A. T., Albanese, C., Lisanti, M. P., Katzenellenbogen, B. S., Kato, S., Hopp, T., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100800200 · Cited by 365 · see citing works

Acetylation of Androgen Receptor Enhances Coactivator Binding and Promotes Prostate Cancer Cell Growth

Fu, M., Rao, M., Wang, C., Sakamaki, T., Wang, J., Vizio, D. D., Zhang, X., Albanese, C., Balk, S. P., Chang, C., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8563-8575.2003 · Cited by 274 · see citing works

The Nuclear Receptor ERRα Is Required for the Bioenergetic and Functional Adaptation to Cardiac Pressure Overload

Huss, J. M., Imahashi, K., Dufour, C. R., Weinheimer, C. J., COURTOIS, M. R., Kovács, A., Giguère, V., Murphy, E., & Kelly, D. P. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.005 · Cited by 264 · see citing works

ERRα: a metabolic function for the oldest orphan

Villena, J. A., & Kralli, A. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.07.005 · Cited by 252 · see citing works

Hormonal Control of Androgen Receptor Function through SIRT1

Fu, M., Liu, M., Sauve, A. A., Jiao, X., Zhang, X., Wu, X., Powell, M. J., Yang, T., Gu, W. J., Avantaggiati, M. L., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00289-06 · Cited by 234 · see citing works

Acetylation of Estrogen Receptor α by p300 at Lysines 266 and 268 Enhances the Deoxyribonucleic Acid Binding and Transactivation Activities of the Receptor

Kim, M. Y., Woo, E. M., Chong, Y. E., Homenko, D. R., & Kraus, W. L. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0531 · Cited by 227 · see citing works

Nuclear receptor ERRα and coactivator PGC-1β are effectors of IFN-γ-induced host defensePreprint

Sonoda, J., Laganière, J., Mehl, I. R., Barish, G. D., Chong, L.-W., Li, X., Scheffler, I. E., Mock, D. C., Bataille, A. R., Robert, F., et al. (2007) · Genes & Development · doi:10.1101/gad.1553007 · Cited by 217 · see citing works

Orphan nuclear receptor estrogen-related receptor α is essential for adaptive thermogenesis

Villena, J. A., Hock, M. B., Chang, W. Y., Barcas, J. E., Giguère, V., & Kralli, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607696104 · Cited by 215 · see citing works

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

Smith, J. J., Kenney, R. D., Gagne, D. J., Frushour, B. P., Ladd, W., Galonek, H. L., Israelian, K., Song, J. J., Razvadauskaite, G., Lynch, A. V., et al. (2009) · BMC Systems Biology · doi:10.1186/1752-0509-3-31 · Cited by 210 · see citing works

Androgen Receptor Acetylation Governs trans Activation and MEKK1-Induced Apoptosis without Affecting In Vitro Sumoylation and trans-Repression Function

Fu, M., Wang, C., Wang, J., Zhang, X., Sakamaki, T., Yeung, Y. G., Chang, C., Hopp, T., Fuqua, S. A. W., Jaffray, E., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3373-3388.2002 · Cited by 170 · see citing works

A Polymorphic Autoregulatory Hormone Response Element in the Human Estrogen-related Receptor α (ERRα) Promoter Dictates Peroxisome Proliferator-activated Receptor γ Coactivator-1α Control of ERRα Expression

Laganière, J., Tremblay, G. B., Dufour, C. R., Giroux, S., Rousseau, F., & Giguère, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313543200 · Cited by 162 · see citing works

Genome-Wide Identification of Direct Target Genes Implicates Estrogen-Related Receptor α as a Determinant of Breast Cancer Heterogeneity

Deblois, G., Hall, J. A., Perry, M.-C., Laganière, J., Ghahremani, M., Park, M., Hallett, M. T., & Giguère, V. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1251 · Cited by 160 · see citing works

The homeobox protein Prox1 is a negative modulator of ERRα/PGC-1α bioenergetic functionsPreprint

Charest-Marcotte, A., Dufour, C. R., Wilson, B. J., Tremblay, A., Eichner, L. J., Arlow, D. H., Mootha, V. K., & Giguère, V. (2010) · Genes & Development · doi:10.1101/gad.1871610 · Cited by 142 · see citing works

The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B.

Hirata, Y., Kiuchi, K., Chen, H. C., Milbrandt, J., & Guroff, G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74536-0 · Cited by 112 · see citing works

Monomeric Complex of Human Orphan Estrogen Related Receptor-2 with DNA: A Pseudo-dimer Interface Mediates Extended Half-site Recognition

Gearhart, M. D., Holmbeck, S. M. A., Evans, R. M., Dyson, H. J., & Wright, P. E. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00183-9 · Cited by 109 · see citing works

Phosphorylation-Dependent Sumoylation Regulates Estrogen-Related Receptor-α and -γ Transcriptional Activity through a Synergy Control Motif

Tremblay, A., Wilson, B. J., Yang, X., & Giguère, V. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0357 · Cited by 105 · see citing works

Epidermal Growth Factor–Induced Signaling in Breast Cancer Cells Results in Selective Target Gene Activation by Orphan Nuclear Receptor Estrogen-Related Receptor α

Barry, J. B., & Giguère, V. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0922 · Cited by 88 · see citing works

Activation of p300 histone acetyltransferase activity and acetylation of the androgen receptor by bombesin in prostate cancer cells

Gong, J.-Y., Zhu, J., Goodman, O. B., Pestell, R. G., Schlegel, P. N., Nanus, D. M., & Shen, R. (2006) · Oncogene · doi:10.1038/sj.onc.1209231 · Cited by 72 · see citing works

p53 Targets Simian Virus 40 Large T Antigen for Acetylation by CBP

Poulin, D. L., Kung, A. L., & DeCaprio, J. A. (2004) · Journal of Virology · doi:10.1128/jvi.78.15.8245-8253.2004 · Cited by 64 · see citing works

Functional Genomics Identifies a Mechanism for Estrogen Activation of the Retinoic Acid Receptor α1 Gene in Breast Cancer Cells

Laganière, J., Deblois, G., & Giguère, V. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0040 · Cited by 62 · see citing works

Acetylation in Nuclear Receptor Signaling and the Role of Sirtuins

Wang, C., Powell, M. J., Popov, V. M., & Pestell, R. G. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0379 · Cited by 39 · see citing works

Nuclear receptor ERR and coactivator PGC-1 are effectors of IFN--induced host defense

Sonoda, J., Laganière, J., Mehl, I. R., Barish, G. D., Chong, L.-W., Li, X., Scheffler, I. E., Mock, D. C., Bataille, A. R., Robert, F., et al. (2007) · Cited by 30 · see citing works

Up-regulation of orphan nuclear estrogen-related receptor alpha expression during long-term caloric restriction in mice

Ranhotra, H. S. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0174-6 · Cited by 29 · see citing works

Acetylation of Estrogen Receptor by p300 at Lysines 266 and 268 Enhances the Deoxyribonucleic Acid Binding and Transactivation Activities of the Receptor

Kim, M. Y., Woo, E. M., Ting, Y., Chong, E. G., Homenko, D. R., & Kraus, W. L. (2007) · Cited by 26 · see citing works

Targeting adipose tissue in the treatment of obesity-associated diabetes

Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678 · see citing works

Dietary Sources and Bioactivities of Melatonin

Meng, X., Li, Y., Li, S., Zhou, Y., Gan, R.-Y., Xu, D.-P., & Li, H.-B. (2017) · Nutrients · doi:10.3390/nu9040367 · Cited by 362 · see citing works

HDAC8: a multifaceted target for therapeutic interventions

Chakrabarti, A., Oehme, I., Witt, O., Oliveira, G., Sippl, W., Romier, C., Pierce, R. J., & Jung, M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.013 · Cited by 284 · see citing works

Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation

Michalek, R. D., Gerriets, V. A., Nichols, A. G., Inoue, M., Kazmin, D., Chang, C.-Y., Dwyer, M. A., Nelson, E. R., Pollizzi, K. N., Ilkayeva, O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108856108 · Cited by 216 · see citing works

Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: Role of PGC-1α

Kang, C., Chung, E., Diffee, G., & Ji, L. L. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.08.004 · Cited by 174 · see citing works

Nuclear receptor coactivators: structural and functional biochemistry

Bulynko, Y. A., & O’Malley, B. W. (2011) · Biochemistry · doi:10.1021/bi101762x · Cited by 113 · see citing works

HDAC8 catalyzes the hydrolysis of long chain fatty acyl lysine

Aramsangtienchai, P., Spiegelman, N. A., He, B., Miller, S. P., Dai, L., Zhao, Y., & Lin, H. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00396 · Cited by 118 · see citing works

Targeting Histone Deacetylase 8 as a Therapeutic Approach to Cancer and Neurodegenerative Diseases

Chakrabarti, A., Melesina, J., Kolbinger, F. R., Oehme, I., Senger, J., Witt, O., Sippl, W., & Jung, M. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0117 · Cited by 111 · see citing works

Decreased sirtuin deacetylase activity in LRRK2 G2019S iPSC-derived dopaminergic neurons

Schwab, A. J., Sison, S. L., Meade, M. R., Broniowska, K. A., Corbett, J. A., & Ebert, A. D. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.010 · Cited by 80 · see citing works

Design, Synthesis, and Biological Activity of NCC149 Derivatives as Histone Deacetylase 8‐Selective Inhibitors

Suzuki, T., Muto, N., Bando, M., Itoh, Y., Masaki, A., Ri, M., Ota, Y., Nakagawa, H., Iida, S., Shirahige, K., et al. (2014) · ChemMedChem · doi:10.1002/cmdc.201300414 · Cited by 71 · see citing works

HDACs and the epigenetic plasticity of cancer cells: target the complexity

Brancolini, C., Gagliano, T., & Minisini, M. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108190 · Cited by 55 · see citing works

HDAC8 functions in spindle assembly during mouse oocyte meiosis

Zhang, K., Lu, Y., Jiang, C., Liu, W., Shu, J., Chen, X., Shi, Y., Wang, E., Wang, L., Hu, Q., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15383 · Cited by 27 · see citing works

Probing p300/CBP Associated Factor (PCAF)-Dependent Pathways with a Small Molecule Inhibitor

Modak, R., Basha, N. J., Bharathy, N., et al. (2013) · ACS Chemical Biology · doi:10.1021/cb4000597 · Cited by 73 · see citing works

Spatial Memory Consolidation is Associated with Induction of Several Lysine-Acetyltransferase (Histone Acetyltransferase) Expression Levels and H2B/H4 Acetylation-Dependent Transcriptional Events in the Rat Hippocampus

Bousiges, O., de Vasconcelos, A. P., Neidl, R., Cosquer, B., Herbeaux, K., Panteleeva, I., Loeffler, J., Cassel, J., & Boutillier, A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.117 · Cited by 190 · see citing works

p300/CBP and p300/CBP-associated Factor with Transcriptional Regulation

Juan, L. (2009) · Zhongguo shengwu huaxue yu fenzi shengwu xuebao

MDM2 Inhibits PCAF (p300/CREB-binding Protein-associated Factor)-mediated p53 Acetylation

Jin, Y., Zeng, S. X., Dai, M., Yang, X., & Lu, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204078200 · Cited by 86 · see citing works

Factor-specific modulation of CREB-binding protein acetyltransferase activity

Perissi, V., Dasen, J. S., Kurokawa, R., Wang, Z., Korzus, E., Rose, D. W., Glass, C. K., & Rosenfeld, M. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3652 · Cited by 104 · see citing works