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Circadian Clock, Cancer, and Chemotherapy
Open accessAbstract
The circadian clock is a global regulatory system that interfaces with most other regulatory systems and pathways in mammalian organisms. Investigations of the circadian clock–DNA damage response connections have revealed that nucleotide excision repair, DNA damage checkpoints, and apoptosis are appreciably influenced by the clock. Although several epidemiological studies in humans and a limited number of genetic studies in mouse model systems have indicated that clock disruption may predispose mammals to cancer, well-controlled genetic studies in mice have not supported the commonly held view that circadian clock disruption is a cancer risk factor. In fact, in the appropriate genetic background, clock disruption may instead aid in cancer regression by promoting intrinsic and extrinsic apoptosis. Finally, the clock may affect the efficacy of cancer treatment (chronochemotherapy) by modulating the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs as well as the activity of the DNA repair enzymes that repair the DNA damage caused by anticancer drugs.
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“Circadian misalignment may alter the rhythms of cellular circadian clocks, and it is believed that this may increase the risk of cancer [48].”
From Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being (2017) · cites this paper as [48]
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Cites
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317
Self-citationCheckpoints: Controls That Ensure the Order of Cell Cycle Events
Hartwell, L. H., & Weinert, T. A. (1989) · Science · doi:10.1126/science.2683079 · Cited by 3,053
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Mechanism of Eukaryotic Homologous Recombination
Filippo, J. S., Sung, P., & Klein, H. L. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061306.125255 · Cited by 1,766
Molecular architecture of the mammalian circadian clock
Partch, C. L., Green, C. B., & Takahashi, J. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.002 · Cited by 1,449
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors
Sancar, A. (2003) · Chemical Reviews · doi:10.1021/cr0204348 · Cited by 1,317
Self-citationFu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00961-3 · Cited by 1,268
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,223
Hotchkiss, R. S., Strasser, A., McDunn, J. E., & Swanson, P. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0901217 · Cited by 1,207
Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo
Matsuo, T., Yamaguchi, S., Mitsui, S., Emi, A., Shimoda, F., & Okamura, H. (2003) · Science · doi:10.1126/science.1086271 · Cited by 1,132
Circadian Gene Expression in Individual Fibroblasts
Nagoshi, E., Saini, C., Bauer, C. R., Laroche, T., Naef, F., & Schibler, U. (2004) · Cell · doi:10.1016/j.cell.2004.11.015 · Cited by 1,031
Temporal Organization: Reflections of a Darwinian Clock-Watcher
Pittendrigh, C. S. (1993) · Annual Review of Physiology · doi:10.1146/annurev.ph.55.030193.000313 · Cited by 1,023
Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902
Harmonics of Circadian Gene Transcription in Mammals
Hughes, M. E., DiTacchio, L., Hayes, K. R., Vollmers, C., Pulivarthy, S. R., Baggs, J. E., Panda, S., & Hogenesch, J. B. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000442 · Cited by 689
Circadian Rhythms: Mechanisms and Therapeutic Implications
Levi, F., & Schibler, U. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105208 · Cited by 645
Gery, S., Komatsu, N., Baldjyan, L., Yu, A., Koo, D., & Koeffler, H. P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.038 · Cited by 630
Paulovich, A. G., & Hartwell, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90481-6 · Cited by 588
Metabolism and cancer: the circadian clock connection
Sahar, S., & Sassone-Corsi, P. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2747 · Cited by 551
Night work and risk of breast cancer
Schernhammer, E. S., Kroenke, C. H., Laden, F., & Hankinson, S. E. (2006) · Epidemiology · doi:10.1097/01.ede.0000190539.03500.c1 · Cited by 484
Mechanisms in Eukaryotic Mismatch Repair
Modrich, P. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600022200 · Cited by 459
Huang, J. C., Svoboda, D. L., Reardon, J. T., & Sancar, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3664 · Cited by 437
Self-citationHost Circadian Clock as a Control Point in Tumor Progression
Filipski, E. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.9.690 · Cited by 413
Circadian Expression of Clock Genes in Human Oral Mucosa and Skin
Bjarnason, G. A., Jordan, R. C., Wood, P. A., Li, Q., Lincoln, D. W., Sothern, R. B., Hrushesky, W. J. M., & Ben‐David, Y. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64135-1 · Cited by 379
DNA repair protects against cutaneous and internal neoplasia: evidence from xeroderma pigmentosum
Kraemer, K. H., Lee, M. M., & Scotto, J. (1984) · Carcinogenesis · doi:10.1093/carcin/5.4.511 · Cited by 374
Circadian Timing of Cancer Chemotherapy
Hrushesky, W. J. M. (1985) · Science · doi:10.1126/science.3883493 · Cited by 372
Genome-wide Expression Analysis of Mouse Liver Reveals CLOCK-regulated Circadian Output Genes
Oishi, K., Miyazaki, K., Kadota, K., Kikuno, R. F., Nagase, T., Atsumi, G.-I., Ohkura, N., Azama, T., Mesaki, M., Yukimasa, S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304564200 · Cited by 349
Light-at-night, circadian disruption and breast cancer: assessment of existing evidence
Stevens, R. G. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp178 · Cited by 345
Core circadian protein CLOCK is a positive regulator of NF-κB–mediated transcription
Spengler, M. L., Kuropatwinski, K. K., Comas, M., Gasparian, A. V., Fedtsova, N. G., Gleiberman, A. S., Gitlin, I. I., Artemicheva, N. M., Deluca, K. A., Gudkov, A. V., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206274109 · Cited by 338
Mori, T., Binder, B. J., & Johnson, C. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10183 · Cited by 332
Gréchez‐Cassiau, A., Rayet, B., Guillaumond, F., Teboul, M., & Delaunay, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705576200 · Cited by 324
Circadian clock control of the cellular response to DNA damage
Sancar, A., Lindsey‐Boltz, L. A., Kang, T., Reardon, J. T., Lee, J. H., & Öztürk, N. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.03.017 · Cited by 322
Self-citationCoupling of Human Circadian and Cell Cycles by the Timeless Protein
Ünsal-Kaçmaz, K., Mullen, T. E., Kaufmann, W. K., & Sancar, A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.8.3109-3116.2005 · Cited by 310
Self-citationThe p53 family in differentiation and tumorigenesis
Stiewe, T. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2072 · Cited by 306
Temporal Coordination of Physiologic FunctionPreprint
Halberg, F. (1960) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1960.025.01.031 · Cited by 298
Gorbacheva, V., Kondratov, R. V., Zhang, R., Cherukuri, S., Gudkov, A. V., Takahashi, J. S., & Antoch, M. P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409897102 · Cited by 275
Network Features of the Mammalian Circadian Clock
Baggs, J. E., Price, T. S., DiTacchio, L., Panda, S., FitzGerald, G. A., & Hogenesch, J. B. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000052 · Cited by 274
Chronopharmacology: New Insights and Therapeutic Implications
Dallmann, R., Brown, S. A., & Gachon, F. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135923 · Cited by 259
NONO couples the circadian clock to the cell cycle
Kowalska, E., Ripperger, J. A., Hoegger, D. C., Bruegger, P., Buch, T., Birchler, T., Mueller, A., Albrecht, U., Contaldo, C., & Brown, S. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213317110 · Cited by 256
Night-shift work and breast cancer – a systematic review and meta-analysis
Ijaz, S., Verbeek, J. H. A. M., Seidler, A., Lindbohm, M.-L., Ojajärvi, A., Orsini, N., Costa, G., & Neuvonen, K. (2013) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3371 · Cited by 254
Geyfman, M., Kumar, V., Liu, Q., Ruiz, R., Gordon, W., Espitia, F., Cam, E., Millar, S. E., Smyth, P., Ihler, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209592109 · Cited by 253
Kang, T.-H., Lindsey-Boltz, L. A., Reardon, J. T., & Sancar, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915085107 · Cited by 250
Self-citationÜnsal-Kaçmaz, K., Chastain, P. D., Qu, P.-P., Minoo, P., Cordeiro-Stone, M., Sancar, A., & Kaufmann, W. K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02190-06 · Cited by 240
Self-citationControl of skin cancer by the circadian rhythm
Gaddameedhi, S., Selby, C. P., Kaufmann, W. K., Smart, R. C., & Sancar, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115249108 · Cited by 238
Self-citationDisrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes
Yu, E. A., & Weaver, D. R. (2011) · Aging · doi:10.18632/aging.100323 · Cited by 236
Cotta‐Ramusino, C., McDonald, E. R., Hurov, K. E., Sowa, M. E., Harper, J. W., & Elledge, S. J. (2011) · Science · doi:10.1126/science.1203430 · Cited by 229
BMAL1-dependent regulation of the mTOR signaling pathway delays aging
Khapre, R. V., Kondratova, A. A., Patel, S. A., Dubrovsky, Y. V., Wrobel, M. M., Antoch, M. P., & Kondratov, R. V. (2014) · Aging · doi:10.18632/aging.100633 · Cited by 218
Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle
Feillet, C. A., Krusche, P., Tamanini, F., Janssens, R. C., Downey, M. J., Martin, P., Teboul, M., Saito, S., Lévi, F., Bretschneider, T., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320474111 · Cited by 211
Circadian oscillation of nucleotide excision repair in mammalian brain
Kang, T., Reardon, J. T., Kemp, M. G., & Sancar, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812638106 · Cited by 210
Self-citationRequirement of Mammalian Timeless for Circadian Rhythmicity
Barnes, J. W., Tischkau, S. A., Barnes, J. A., Mitchell, J. W., Burgoon, P. W., Hickok, J. R., & Gillette, M. U. (2003) · Science · doi:10.1126/science.1086593 · Cited by 207
Swi1 and Swi3 Are Components of a Replication Fork Protection Complex in Fission Yeast
Noguchi, E., Noguchi, C., McDonald, W. H., Yates, J. R., & Russell, P. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8342-8355.2004 · Cited by 205
The role of p53 in tumour suppression: lessons from mouse models
Attardi, L. D., & Jacks, T. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050269 · Cited by 203
Loss of cryptochrome reduces cancer risk in p53 mutant mice
Öztürk, N., Lee, J. H., Gaddameedhi, S., & Sancar, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813028106 · Cited by 199
Self-citationCryptochrome, Circadian Cycle, Cell Cycle Checkpoints, and Cancer
Gauger, M. A., & Sancar, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1119 · Cited by 185
Self-citationA time-less function for mouse Timeless
Gotter, A. L., Manganaro, T. F., Weaver, D. R., Kolakowski, L. F., Possidente, B. P., Sathyanarayanan, S., MacLaughlin, D. T., & Reppert, S. M. (2000) · Nature Neuroscience · doi:10.1038/77653 · Cited by 181
Mammalian Clock Gene Cryptochrome Regulates Arthritis via Proinflammatory Cytokine TNF-α
Hashiramoto, A., Yamane, T., Tsumiyama, K., Yoshida, K., Komai, K., Yamada, H., Yamazaki, F., Doi, M., Okamura, H., & Shiozawa, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0903284 · Cited by 174
Molecular Analysis of Mammalian Timeless
Zylka, M. J., Shearman, L. P., Levine, J. D., Jin, X., Weaver, D. R., & Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80628-5 · Cited by 169
AMPK at the crossroads of circadian clocks and metabolism
Jordan, S. D., & Lamia, K. A. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.017 · Cited by 168
Plikus, M. V., Vollmers, C., de la Cruz, D., Chaix, A., Ramos, R., Panda, S., & Chuong, C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215935110 · Cited by 163
Night-Shift Work and Breast Cancer Risk in a Cohort of Chinese Women
Pronk, A., Ji, B. T., Shu, X. O., Xue, S., Yang, G., Li, H. L., Rothman, N., Gao, Y. T., Zheng, W., & Chow, W. H. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq029 · Cited by 160
Chromosome cohesion is regulated by a clock gene paralogue TIM-1
Chan, R. C., Chan, A., Jeon, M., Wu, T. F., Pasqualone, D., Rougvie, A. E., & Meyer, B. J. (2003) · Nature · doi:10.1038/nature01697 · Cited by 156
Adverse Health Effects of Nighttime Lighting
Stevens, R. G., Brainard, G. C., Blask, D. E., Lockley, S. W., & Motta, M. E. (2013) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2013.04.011 · Cited by 152
Antoch, M. P., Gorbacheva, V., Vykhovanets, O. V., Toshkov, I. A., Kondratov, R. V., Kondratova, A. A., Lee, C., & Nikitin, A. Y. (2008) · Cell Cycle · doi:10.4161/cc.7.9.5886 · Cited by 148
Regulation of the Mammalian Circadian Clock by Cryptochrome
Sancar, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400016200 · Cited by 148
Self-citationDaily and Circadian Variation in Survival From Ultraviolet Radiation in Chlamydomonas reinhardtii
Nikaido, S. S., & Johnson, C. H. (2000) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2000)0710758dacvis2.0.co2 · Cited by 144
Mammalian TIMELESS and Tipin are Evolutionarily Conserved Replication Fork-associated Factors
Gotter, A. L., Suppa, C., & Emanuel, B. S. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.10.097 · Cited by 142
Mohanty, B. K., Bairwa, N. K., & Bastia, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506540103 · Cited by 134
Phase Resetting of the Mammalian Circadian Clock by DNA Damage
Oklejewicz, M., Destici, E., Tamanini, F., Hut, R. A., Janssens, R. C., & van der Horst, G. T. J. (2008) · Current Biology · doi:10.1016/j.cub.2008.01.047 · Cited by 132
The Coevolution of Blue-Light Photoreception and Circadian Rhythms
Gehring, W., & Rosbash, M. (2003) · Journal of Molecular Evolution · doi:10.1007/s00239-003-0038-8 · Cited by 132
Kang, T.-H., Reardon, J. T., & Sancar, A. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1318 · Cited by 124
Self-citationRegulation of apoptosis by the circadian clock through NF-κB signaling
Lee, J. H., & Sancar, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108125108 · Cited by 117
Self-citationCircadian proteins in the regulation of cell cycle and genotoxic stress responses
Kondratov, R. V., & Antoch, M. P. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.001 · Cited by 108
Nucleotide Excision Repair in Human Cells
Hu, J., Choi, J.-H., Gaddameedhi, S., Kemp, M. G., Reardon, J. T., & Sancar, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.482257 · Cited by 108
Self-citationThe Role of Clock Genes in Pharmacology
Paschos, G. K., Baggs, J. E., Hogenesch, J. B., & FitzGerald, G. A. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105621 · Cited by 105
Mechanism of Release and Fate of Excised Oligonucleotides during Nucleotide Excision Repair
Kemp, M. G., Reardon, J. T., Lindsey‐Boltz, L. A., & Sancar, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374447 · Cited by 103
Self-citationA network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells
Yu, J., Baron, V. T., Mercola, D., Mustelin, T., & Adamson, E. D. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402029 · Cited by 101
Circadian clocks and cell division
Johnson, C. H. (2010) · Cell Cycle · doi:10.4161/cc.9.19.13205 · Cited by 101
Circadian regulation of cryptochrome genes in the mouse
Miyamoto, Y., & Sancar, A. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00192-8 · Cited by 98
Self-citationBoth products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo
Sharpless, N. E., Kannan, K., Xu, J., Bosenberg, M., & Chin, L. (2003) · Oncogene · doi:10.1038/sj.onc.1206809 · Cited by 97
Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1
Kang, T., & Leem, S.-H. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku094 · Cited by 91
Drosophila timeless2 Is Required for Chromosome Stability and Circadian Photoreception
Benna, C., Bonaccorsi, S., Wülbeck, C., Helfrich‐Förster, C., Gatti, M., Kyriacou, C. P., Costa, R., & Sandrelli, F. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.048 · Cited by 82
PERIOD1 is an Anti-apoptotic Factor in Human Pancreatic and Hepatic Cancer Cells
Sato, F., Nagata, C., Liu, Y., Suzuki, T., Kondo, J., Morohashi, S., Imaizumi, T., Kato, Y., & Kijima, H. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp126 · Cited by 80
A second timeless gene in Drosophila shares greater sequence similarity with mammalian tim
Benna, C., Scannapieco, P., Piccin, A., Sandrelli, F., Zordan, M. A., Rosato, E., Kyriacou, C. P., Valle, G., & Costa, R. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00594-7 · Cited by 79
Engelen, E., Janssens, R. C., Yagita, K., Smits, V. A. J., van der Horst, G. T. J., & Tamanini, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056623 · Cited by 78
Brown, W. R. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12480379 · Cited by 77
IS LIGHT-AT-NIGHT A HEALTH RISK FACTOR OR A HEALTH RISK PREDICTOR?
Kantermann, T., & Roenneberg, T. (2009) · Chronobiology International · doi:10.3109/07420520903223984 · Cited by 76
Circadian Clock Genes as Modulators of Sensitivity to Genotoxic Stress
Antoch, M. P., Kondratov, R. V., & Takahashi, J. S. (2005) · Cell Cycle · doi:10.4161/cc.4.7.1792 · Cited by 73
Identification and Validation of Cryptochrome Inhibitors That Modulate the Molecular Circadian Clock
Chun, S. K., Jang, J., Chung, S., Yun, H., Kim, N., Jung, J., Son, G. H., Suh, Y., & Kim, K. (2014) · ACS Chemical Biology · doi:10.1021/cb400752k · Cited by 69
Circadian Gene Expression in Cultured Cells
Nagoshi, E., Brown, S. A., Dibner, C., Kornmann, B., & Schibler, U. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)93028-0 · Cited by 67
Circadian-independent cell mitosis in immortalized fibroblasts
Yeom, M., Pendergast, J. S., Ohmiya, Y., & Yamazaki, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914078107 · Cited by 67
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
Lee, J. H., & Sancar, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106284108 · Cited by 65
Self-citationGotter, A. L. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00633-8 · Cited by 64
Cyclin-dependent kinase inhibitor p20 controls circadian cell-cycle timing
Laranjeiro, R., Tamai, K., Peyric, E., Krusche, P., Ott, S., & Whitmore, D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217912110 · Cited by 58
Effect of circadian clock mutations on DNA damage response in mammalian cells
Gaddameedhi, S., Reardon, J. T., Ye, R., Öztürk, N., & Sancar, A. (2012) · Cell Cycle · doi:10.4161/cc.21771 · Cited by 54
Self-citationSato, F., Wu, Y., BHAWAL, U. K., Liu, Y., Imaizumi, T., Morohashi, S., Kato, Y., & Kijima, H. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.02.025 · Cited by 50
Antoch, M. P., Toshkov, I. A., Kuropatwinski, K. K., & Jackson, M. (2013) · Cell Cycle · doi:10.4161/cc.26614 · Cited by 42
DNA Damage–Specific Control of Cell Death by Cryptochrome in p53-Mutant Ras–Transformed Cells
Lee, J. H., Gaddameedhi, S., Öztürk, N., Ye, R., & Sancar, A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1994 · Cited by 42
Self-citationDanish night shift workers with breast cancer awarded compensation
Wise, J. (2009) · BMJ · doi:10.1136/bmj.b1152 · Cited by 41
Antoch, M. P., & Kondratov, R. V. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_12 · Cited by 41
Timeless in lung morphogenesis
Xiao, J., Li, C., Zhu, N., Borok, Z., & Minoo, P. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10346 · Cited by 31
Elevated mPer1 gene expression in tumor stroma imaged through bioluminescence
Geusz, M. E., Blakely, K. T., Hiler, D. J., & Jamasbi, R. J. (2009) · International Journal of Cancer · doi:10.1002/ijc.24788 · Cited by 16
Beland, F. A., Dooley, K. L., Sheldon, W. G., & Delongchamp, R. R. (1988) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/80.5.325 · Cited by 12
Stevens, R. G., Hansen, J., Schernhammer, E. S., & Davis, S. (2013) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3385 · Cited by 11
Partch, C. L. (2014) · Cell Cycle · doi:10.4161/cc.27862 · Cited by 1
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1 of the 105 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Transcriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,786
Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being
James, S. M., Honn, K. A., Gaddameedhi, S., & Van Dongen, H. P. A. (2017) · Current Sleep Medicine Reports · doi:10.1007/s40675-017-0071-6 · Cited by 517
Self-citationBallesta, A., Innominato, P. F., Dallmann, R., Rand, D. A. J., & Lévi, F. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013441 · Cited by 348
Clocks, cancer, and chronochemotherapy
Sancar, A., & Gelder, R. N. V. (2020) · Science · doi:10.1126/science.abb0738 · Cited by 285
Self-citationMechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)
Sancar, A. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201601524 · Cited by 283
Self-citation
Metadata
- Authors
- Sancar, A., Lindsey-Boltz, L. A., Gaddameedhi, S., Selby, C. P., Ye, R., Chiou, Y.-Y., Kemp, M. G., Hu, J., Lee, J. H., & Ozturk, N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of North Carolina School of Medicine , , , ,
- Corresponding author
- Sancar, Aziz
- ORCID
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-10-10
- Volume
- 54
- Issue
- 2
- Pages
- 110-123
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- PMC
- PMC4303322
- OpenAlex
- W2139669192
- Cited by
- 170
- References
- 105
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 11 · 2023: 8 · 2022: 14 · 2021: 15 · 2020: 18 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 18 · 2015: 7 · 2014: 1
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Biochemistry (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institute of General Medical Sciences (GM31082, GM32833)
- National Science Council Taiwan (NA)
- Academia Sinica (NA)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Keywords
- circadian clock, cancer, DNA damage response, nucleotide excision repair, DNA damage checkpoint, apoptosis, cancer risk, tumor regression, pharmacokinetics, pharmacodynamics, anticancer agents, DNA repair enzymes
- MeSH terms
- Animals, Antineoplastic Agents, DNA Damage, DNA Repair, Humans, Neoplasms, Risk Factors, Apoptosis, DNA Repair Enzymes, Drug Chronotherapy, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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