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Cited by 888

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Porous 3-D Scaffolds from Regenerated Silk Fibroin

Nazarov, Rina, Jin, Hyoung-Joon, Kaplan, David L.·2004·Biomacromolecules
DOI 10.1021/bm034327e
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Abstract

Three fabrication techniques, freeze-drying, salt leaching and gas foaming, were used to form porous three-dimensional silk biomaterial matrixes. Matrixes were characterized for morphological and functional properties related to processing method and conditions. The porosity of the salt leached scaffolds varied between 84 and 98% with a compressive strength up to 175 +/- 3 KPa, and the gas foamed scaffolds had porosities of 87-97% and compressive strength up to 280 +/- 4 KPa. The freeze-dried scaffolds were prepared at different freezing temperatures (-80 and -20 degrees C) and subsequently treated with different concentrations (15 and 25%) and hydrophilicity alcohols. The porosity of these scaffolds was up to 99%, and the maximum compressive strength was 30 +/- 2 KPa. Changes in silk fibroin structure during processing to form the 3D matrixes were determined by FT-IR and XrD. The salt leached and gas foaming techniques produced scaffolds with a useful combination of high compressive strength, interconnected pores, and pore sizes greater than 100 microns in diameter. The results suggest that silk-based 3D matrixes can be formed for utility in biomaterial applications.

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Metadata

Authors
Nazarov, R., Jin, H.-J., & Kaplan, D. L.
Venue
Biomacromolecules
Publisher
American Chemical Society (ACS)
Published
2004-01-23
Volume
5
Issue
3
Pages
718-726
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
DOI
10.1021/bm034327e
OpenAlex
W2091107068
Cited by
888
References
1
FWCI
13.36
Type
journal article
Language
en
Open access
closed

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