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Cited by 310

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Blends of Poly-(ε-caprolactone) and Polysaccharides in Tissue Engineering Applications

Ciardelli, Gianluca, Chiono, Valeria, Vozzi, Giovanni, Pracella, Mariano, Ahluwalia, Arti, Barbani, Niccoletta, Cristallini, Caterina, Giusti, Paolo·2005·Biomacromolecules
DOI 10.1021/bm0500805
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Abstract

Bioartificial blends of poly-(epsilon-caprolactone) (PCL) with a polysaccharide (starch, S; dextran, D; or gellan, G) (PCL/S, PCL/D, PCL/G 90.9/9.1 wt ratio) were prepared by a solution-precipitation technique and widely characterized by differential scanning calorimetry analysis (DSC), Fourier transform infrared-attenuated total reflectance spectroscopy (FTIR-ATR), optical microscopy (OM), wide-angle X-ray diffraction analysis (WAXD), and thermogravimetry (TGA). DSC showed that the polysaccharide reduced the crystallinity of PCL and had a nucleation effect, which was also confirmed by OM analysis. Hoffman-Weeks analysis was performed on PCL and blend samples allowing calculation of their equilibrium melting temperatures (). WAXD showed that the crystalline unit cell type was the same for PCL and blends. FTIR-ATR did not evidence interactions between blend components. Thermal stability was affected by the type of polysaccharide. Microparticles (<125 microm) were produced from blends by cryogenical milling and characterized by scanning electron microscopy analysis (SEM). Selective laser sintering (SLS), a new rapid prototyping technology for scaffold fabrication, was applied to sinter blend microparticles according to a PC-designed two-dimensional geometry (strips and 2 x 2 mm(2) square-meshed grids). The optimal experimental conditions for sintering were established and laser beam parameters (beam speed, BS, and power, P) were found for each blend composition. Morphology of sintered objects was analyzed by SEM and found to be dependent on the morphology of the sintered powders. Sintered samples were analyzed by chemical imaging (CI), FTIR-ATR, DSC, and contact angle analysis. No evidence of the occurrence of degradation phenomena was found by FTIR-ATR for sintered samples, whereas DSC parameters of PCL and blends showed changes which could be attributed to some molecular weight decrease of PCL during sintering. CI of sintered samples showed that the polysaccharide phase was homogeneously dispersed within the PCL matrix, with the only exception being the PCL/D blend. The contact angle analysis showed that all samples were hydrophilic. Fibroblasts were then seeded on scaffolds to evaluate the rate and the extent of cell adhesion and the effect of the polysaccharides (S, D, G) on the bioactivity of the PCL-based blends.

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Metadata

Authors
Ciardelli, G., Chiono, V., Vozzi, G., Pracella, M., Ahluwalia, A., Barbani, N., Cristallini, C., & Giusti, P.
Venue
Biomacromolecules
Publisher
American Chemical Society (ACS)
Published
2005-04-27
Volume
6
Issue
4
Pages
1961-1976
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
DOI
10.1021/bm0500805
OpenAlex
W1999940864
Cited by
310
References
35
FWCI
6.52
Type
journal article
Language
en
Open access
closed

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