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PAMAM Dendrimer-Based Multifunctional Conjugate for Cancer Therapy: Synthesis, Characterization, and Functionality
Abstract
Poly(amidoamine) (PAMAM) dendrimer-based multifunctional cancer therapeutic conjugates have been designed and synthesized. The primary amino groups on the surface of the generation 5 (G5) PAMAM dendrimer were neutralized through partial acetylation, providing enhanced solubility of the dendrimer (in conjugation of FITC (fluorescein isothiocyanate)) and preventing nonspecific targeting interactions (in vitro and in vivo) during delivery. The functional molecules fluorescein isothiocyanate (FITC, an imaging agent), folic acid (FA, targets overexpressed folate receptors on specific cancer cells), and paclitaxel (taxol, a chemotherapeutic drug) were conjugated to the remaining nonacetylated primary amino groups. The appropriate control dendrimer conjugates have been synthesized as well. Characterization of the G5 PAMAM dendrimer and its nanosize conjugates, including the molecular weight and number of primary amine groups, has been determined by multiple analytical methods such as gel permeation chromatography (GPC), nuclear magnetic resonance spectroscopy (NMR), potentiometric titration, high-performance liquid chromatography (HPLC), and UV spectroscopy. These multifunctional dendrimer conjugates have been tested in vitro for targeted delivery of chemotherapeutic and imaging agents to specific cancer cells. We present here the synthesis, characterization, and functionality of these dendrimer conjugates.
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Slamon, D. J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Fleming, T., Eiermann, W., Wolter, J., Pegram, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103153441101 · Cited by 11,500
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Caruthers, S. D., Wickline, S. A., & Lanza, G. M. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.01.006 · Cited by 441
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Oliveira, J. M., Salgado, A. J., Sousa, N., Mano, J. F., & Reis, R. L. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.04.006 · Cited by 182
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Yu, Y., Chen, C.-K., Law, W.-C., Weinheimer, E., Sengupta, S., Prasad, P. N., & Cheng, C. (2014) · Biomacromolecules · doi:10.1021/bm401471p · Cited by 134
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Metadata
- Authors
- Majoros, I. J., Myc, A., Thomas, T., Mehta, C. B., & Baker, J. R.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-01-13
- Volume
- 7
- Issue
- 2
- Pages
- 572-579
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2013086386
- Cited by
- 596
- References
- 1
- FWCI
- 41.94
- Type
- journal article
- Language
- en
- Open access
- closed
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