The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cellular Micropatterns on Biocompatible Materials
Abstract
We present a method to produce micropatterns of cells on tissue culture substrates. A network of deep elastomeric microchannels defining the desired pattern is sealed onto the surface of interest, and a protein template is created by injecting sub-milliliter quantities of protein solution into the microchannels. Protein adsorbs only on the areas that were exposed to the microflow. After the channels are flushed and the elastomer is removed, cells attach only on the protein template. Micropatterns of collagen or fibronectin were used to selectively adhere cells on various biomedical polymers and on heterogeneous or microtextured substrates. Since the bare substrate areas remain apt for seeding other, more adhesive cell types such as fibroblasts, we were able to create micropatterned co-cultures. Our method allows for inexpensive patterning of a rich assortment of biomolecules, cells, and surfaces under physiological conditions.
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Cites
Biomaterials in Tissue Engineering
Hubbell, J. A. (1995) · Nature Biotechnology · doi:10.1038/nbt0695-565 · Cited by 1,060
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Metadata
- Authors
- Folch, A., & Toner, M.
- Venue
- Biotechnology Progress
- Publisher
- Wiley
- Published
- 1998-06-05
- Volume
- 14
- Issue
- 3
- Pages
- 388-392
- ISSN
- 1520-6033 (ISSN-L)
- 8756-7938
- OpenAlex
- W2098764169
- Cited by
- 270
- References
- 1
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
