The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Getting in Shape: Controlling Peptide Bioactivity and Bioavailability Using Conformational Constraints
Open accessAbstract
Chemical biologists commonly seek out correlations between the physicochemical properties of molecules and their behavior in biological systems. However, a new paradigm is emerging for peptides in which conformation is recognized as the primary determinant of bioactivity and bioavailability. This review highlights an emerging body of work that directly addresses how a peptide's conformation controls its biological effects, cell penetration, and intestinal absorption. Based on this work, the dream of mimicking the potency and bioavailability of natural product peptides is getting closer to reality.
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Cites
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Getting Across the Cell Membrane: An Overview for Small Molecules, Peptides, and Proteins
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Multifaceted Roles of Disulfide Bonds. Peptides as Therapeutics
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Hydrocarbon Stapled Peptides as Modulators of Biological Function
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Biosynthesis and Chemical Applications of Thioamides
Mahanta, N., Szantai-Kis, D. M., Petersson, E. J., & Mitchell, D. A. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.8b01022 · Cited by 218
Metadata
- Authors
- Bock, J. E., Gavenonis, J., & Kritzer, J. A.
- Venue
- ACS Chemical Biology
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-11-30
- Volume
- 8
- Issue
- 3
- Pages
- 488-499
- ISSN
- 1554-8929 (ISSN-L)
- 1554-8937
- OpenAlex
- W1991832692
- Cited by
- 221
- References
- 13
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- green
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