Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
Haeggström, Jesper Z., Funk, Colin D.·2011·Chemical Reviews
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- Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltrationZhihua Wen, Huan Liu, Mansheng Li, B Li, Wei Gao, Qianqian Shao, B. Fan, Fanghui Zhao, Q Wang, Qi Xie et al. · 2014 · Oncogene
- Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke TherapiesGanesha Rai, Netra Joshi, Joo Eun Jung, Yu Liu, Lena Schultz, Adam Yasgar, Steve Perry, Giovanni Diaz, Qiangli Zhang, Victor A. Kenyon et al. · 2014 · Journal of Medicinal Chemistry
- The eosinophil chemoattractant 5-oxo-ETE and the OXE receptorWilliam S. Powell, Joshua Rokach · 2013 · Progress in Lipid Research
- The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's diseaseYash B. Joshi, Phillip F. Giannopoulos, Domenico Praticò · 2015 · Trends in Pharmacological Sciences
- Leukotrienes in Tumor-Associated InflammationWen Tian, Xinguo Jiang, Dongeon Kim, Torrey Guan, Mark Robert Nicolls, Stanley G. Rockson · 2020 · Frontiers in Pharmacology
- Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signalingThomas L. Horn, Susan Adel, Ralf R. Schumann, Saubashya Sur, Kumar Reddy Kakularam, Polamarasetty Aparoy, Pallu Reddanna, Hartmut Kühn, Dagmar Heydeck · 2014 · Progress in Lipid Research
- Mammalian ALOX15 orthologs exhibit pronounced dual positional specificity with docosahexaenoic acidLaura Kutzner, Kateryna Goloshchapova, Dagmar Heydeck, Sabine Stehling, Hartmut Kühn, Nils Helge Schebb · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
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- Eicosanoids in Metabolic SyndromeJames P. Hardwick, Katie Eckman, Yoon‐Kwang Lee, Mohamed A. Abdelmegeed, Andrew R. Esterle, William M. Chilian, John Y.L. Chiang, Byoung‐Joon Song · 2013 · Advances in pharmacology
- Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4ratio in children with cystic fibrosisFiona Ringholz, Paul Buchanan, Donna Clarke, Roisin G. Millar, Michael McDermott, Barry M. Linnane, Brian Joseph Harvey, Paul McNally, Valérie Urbach · 2014 · European Respiratory Journal
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- Biosynthesis of leukotriene B4Min Wan, Xiao Yan Tang, Alena Stsiapanava, Jesper Z. Haeggström · 2017 · Seminars in Immunology
- Anti-tumor activities of lipids and lipid analogues and their development as potential anticancer drugsMichael T. Murray, Adam Hraiki, Mary Bebawy, Curtis Pazderka, Tristan Rawling · 2015 · Pharmacology & Therapeutics
- Hydrogen–Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron TunnelingAdam R. Offenbacher, Shenshen Hu, Erin M. Poss, Cody A. Marcus Carr, Alexander D. Scouras, Daniil M. Prigozhin, Anthony T. Iavarone, Ali Palla, Tom Alber, James S. Fraser et al. · 2017 · ACS Central Science
- Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic ReviewJuan Antonio Giménez‐Bastida, Antonio González‐Sarrías, José Moisés Laparra, Claus G. Schneider, Juan Carlos Espı́n · 2021 · International Journal of Molecular Sciences
- Dietary omega-3 PUFA and health: Stearidonic acid-containing seed oils as effective and sustainable alternatives to traditional marine oilsMarc E. Surette · 2013 · Molecular Nutrition & Food Research
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- Oxidized Lipids in Persistent Pain StatesTabea Osthues, Marco Sisignano · 2019 · Frontiers in Pharmacology
- Recombinant Lipoxygenases and Hydroperoxide Lyases for the Synthesis of Green Leaf VolatilesHolly Stolterfoht, Claudia Rinnofner, Margit Winkler, Harald Pichler · 2019 · Journal of Agricultural and Food Chemistry
- Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product BiosynthesisNathchar Naowarojna, Ronghai Cheng, Li Chen, Melissa Quill, Meiling Xu, Changming Zhao, Pinghua Liu · 2018 · Biochemistry
- Ferroptosis: Biochemistry and Biology in CancersZhiyuan Shi, Lei Zhang, Jianzhong Zheng, Huimin Sun, Chen Shao · 2021 · Frontiers in Oncology
- Crystal Structure of Manganese Lipoxygenase of the Rice Blast Fungus Magnaporthe oryzaeAnneli Wennman, Ernst H. Oliw, Saeid Karkehabadi, Yang Chen · 2016 · Journal of Biological Chemistry
- GM‐CSF– and M‐CSF–primed macrophages present similar resolving but distinct inflammatory lipid mediator signaturesAna Lukic, Pia Larssen, Alexander Fauland, Bengt O. Samuelsson, Craig Edward Wheelock, Susanne Gabrielsson, Olof Rådmark · 2017 · The FASEB Journal
- Allergic Asthmatics Show Divergent Lipid Mediator Profiles from Healthy Controls Both at Baseline and following Birch Pollen ProvocationSusanna L. Lundström, Jun Yang, Henrik Källberg, Sarah Thunberg, Guro Gafvelin, Jesper Z. Haeggström, Reidar Grönneberg, Johan Grünewald, Marianne van Hage, Bruce D. Hammock et al. · 2012 · PLoS ONE
- Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxinsSusan Adel, Felix Karst, Àngels González‐Lafont, Mária Pekárová, Patricia Saura, Laura Masgrau, José M. Lluch, Sabine Stehling, Thomas L. Horn, Hartmut Kühn et al. · 2016 · Proceedings of the National Academy of Sciences
- The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologsHartmut Kühn, Lia Humeniuk, Nikita Kozlov, Sophie Roigas, Susan Adel, Dagmar Heydeck · 2018 · Progress in Lipid Research
- Diatomic iron nanozyme with lipoxidase-like activity for efficient inactivation of enveloped virusBeibei Li, Ruonan Ma, Lei Chen, Caiyu Zhou, Yu‐Xiao Zhang, Xiaonan Wang, Helai Huang, Qikun Hu, Xiaobo Zheng, Jiarui Yang et al. · 2023 · Nature Communications
- The Role of the ω‐3 Fatty Acid DHA in the Human Life CycleSarah J. Carlson, Erica M. Fallon, Brian Thomas Kalish, Kathleen M. Gura, Mark Puder · 2012 · Journal of Parenteral and Enteral Nutrition
- LC-MS/MS profiles and interrelationships between the anti-inflammatory activity, total phenolic content and antioxidant potential of Kalasin 2 cultivar peanut sprout crude extractApinun Limmongkon, Phatcharaporn Nopprang, Penpitcha Chaikeandee, Thapakorn Somboon, Pakwuan Wongshaya, Vijakhana Pilaisangsuree · 2017 · Food Chemistry
- Group 2 Innate Lymphoid Cells: Team Players in Regulating AsthmaNoé Rodríguez‐Rodríguez, Mayuri Gogoi, Andrew N. J. McKenzie · 2021 · Annual Review of Immunology
- Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infectionsPaul Mike Jordan, Oliver Werz · 2021 · FEBS Journal
- Paired Hierarchical Organization of 13-Lipoxygenases in ArabidopsisAdeline Chauvin, Aurore Lenglet, Jean‐Luc Wolfender, Edward E. Farmer · 2016 · Plants
- A cluster of immunoresolvents links coagulation to innate host defense in human bloodPaul C. Norris, Stephania Libreros, Nan Chiang, Charles Nicholas Serhan · 2017 · Science Signaling
- Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosisMarkus Bock, Mirjam Karber, Hartmut Kühn · 2018 · EBioMedicine
- Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5Min Wan, Xiang Hua, Jun Su, Divya Thiagarajan, Anna G. Frostegård, Jesper Z. Haeggström, Johan Frostegård · 2014 · Atherosclerosis
- Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acidAnders Vik, Jesmond Dalli, Trond Vidar Hansen · 2017 · Bioorganic & Medicinal Chemistry Letters
- Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesisTuğçe Gür Maz, Burcu Çalışkan, Erden Banoğlu · 2017 · European Journal of Medicinal Chemistry
- Current perspective on eicosanoids in asthma and allergic diseases: EAACI Task Force consensus report, part IMilena Sokołowska, G. Enrico Rovati, Zuzana Diamant, Eva Untersmayr, Jürgen Schwarze, Zuzanna Małgorzata Łukasik, Florentina Sava, Alba Angelina, Óscar Palomares, Cezmi A. Akdiş et al. · 2020 · Allergy
- SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?Ming Yang, Ching‐Lung Lai · 2020 · Cell Death Discovery
- Ferroptosis as a new tool for tumor suppression through lipid peroxidationXin Ping Yang, Yanqing Liu, Zhe Wang, Ying Jin, Wei Jun Gu · 2024 · Communications Biology
- Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3Jesmond Dalli, Julia M. Sanger, Ana R. Rodrı́guez, Nan Chiang, Bernd Werner Spur, Charles Nicholas Serhan · 2016 · PLoS ONE
- Development of a new colorimetric assay for lipoxygenase activityWeiqiang Lü, Xue Zhi Zhao, Zhongyu Xu, Ningning Dong, Shien Zou, Xu Shen, Jin Yan Huang · 2013 · Analytical Biochemistry
- Involvement of Fatty Acids and Their Metabolites in the Development of Inflammation in AtherosclerosisStanislav Nikolaevich Kotlyarov, Анна Анатольевна Котлярова · 2022 · International Journal of Molecular Sciences
- The ALOX5 inhibitor Zileuton regulates tumor-associated macrophage M2 polarization by JAK/STAT and inhibits pancreatic cancer invasion and metastasisWeimin Hu, Si-Qing Liu, Kongfan Zhu, Wei Li, Zhi-Jian Yang, Qiang Yang, Zhu Zhong-chao, Jian Chang · 2023 · International Immunopharmacology
- Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood–brain barrier dysfunctionQuéli Fernandes Lenz, Daniela Soledad Arroyo, Fernanda Rossatto Temp, Alice Bertotto Poersch, C.J. Masson, Ana Cláudia Jesse, Joseane Righes Marafiga, Cristina Ruedell Reschke, Pablo Iribarren, Carlos Fernando Mello · 2014 · Neuroscience
- Novel mediators and mechanisms in the resolution of infectious inflammation: evidence for vagus regulationCharles Nicholas Serhan, Xavier de la Rosa, Charlotte Camille Jouvene · 2018 · Journal of Internal Medicine
- Iron-dependent trafficking of 5-lipoxygenase and impact on human macrophage activationDufrusine, Beatrice, Di Francesco, Andrea, Oddi, Sergio, Scipioni, Lucia, Angelucci, Clotilde Beatrice, D'Addario, Claudio, Serafini, Mauro, Häfner, Ann-Kathrin, Steinhilber, Dieter, Maccarrone, Mauro et al. · 2019 · Frontiers in Immunology
- Beany flavor in pea protein: Recent advances in formation mechanism, analytical techniques and microbial fermentation mitigation strategiesLongbei Xiang, Bo Jiang, Youling L. Xiong, Leon Zhou, Fang Zhong, Ran Zhang, Assam Bin Tahir, Ziqun Xiao · 2023 · Food Bioscience
- Social Networking of Group Two Innate Lymphoid Cells in Allergy and AsthmaBenjamin P. Hurrell, Pedram Shafiei-Jahani, Omid Akbari · 2018 · Frontiers in Immunology
- Stability of oxylipins during plasma generation and long-term storageElisabeth Koch, Malwina Mainka, Céline Dalle, Annika Irmgard Ostermann, Katharina M. Rund, Laura Kutzner, Laura‐Fabienne Fröhlich, Justine Bertrand‐Michel, Cécile Gladine, Nils Helge Schebb · 2020 · Talanta
- Ferroptosis as a new therapeutic opportunity for nonviral liver diseaseMin Jia, Hongmei Zhang, Qiaohong Qin, Ying Hou, Xin Zhang, Di Chen, Hong Zhang, Yulong Chen · 2021 · European Journal of Pharmacology
- Modulating the Blood–Brain Barrier: A Comprehensive ReviewRory Whelan, Gráinne C. Hargaden, Andrew J. S. Knox · 2021 · Pharmaceutics
- Protectins: Their biosynthesis, metabolism and structure-functionsTrond Vidar Hansen, Charles Nicholas Serhan · 2022 · Biochemical Pharmacology
- Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarctionVasundhara Kain, Kevin A. Ingle, Janusz H. S. Kabarowski, Stephen Barnes, Nita A. Limdi, Sumanth D. Prabhu, Ganesh V. Halade · 2018 · Journal of Molecular and Cellular Cardiology
- Free docosahexaenoic acid promotes ferroptotic cell death via lipoxygenase dependent and independent pathways in cancer cellsKai Shan, Ninghan Feng, Doudou Zhu, Hongyan Qu, Guoling Fu, Jiaqi Li, Jing Cui, Heyan Chen, Rong Wang, Yumin Qi et al. · 2022 · European Journal of Nutrition
- Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymesPalwinder Singh, Parteek Prasher, Parvirti Dhillon, Rajbir Bhatti · 2015 · European Journal of Medicinal Chemistry
- Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory PropertiesNikolaos Eleftheriadis, Constantinos G. Neochoritis, Niek G.J. Leus, Petra E. van der Wouden, Alexander S. S. Dömling, Frank J. Dekker · 2015 · Journal of Medicinal Chemistry
- The leukotriene receptor antagonist montelukast and its possible role in the cardiovascular fieldMalvina Hoxha, G. Enrico Rovati, Aurora Bueno‐Cavanillas · 2017 · European Journal of Clinical Pharmacology
- FADS genetic and metabolomic analyses identify the ∆5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipidsLindsay M. Reynolds, Rahul Dutta, Michael C. Seeds, Kirsten N. Lake, Brian Hallmark, Rasika A. Mathias, Timothy D. Howard, Floyd H. Chilton · 2020 · Scientific Reports
- Binding of Pro-Gly-Pro at the active site of leukotriene A 4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitorAlena Stsiapanava, Ulrika Olsson, Min Wan, Thea K. Kleinschmidt, Dorothea Rutishauser, Roman A. Zubarev, Bengt O. Samuelsson, Agnes Rinaldo-Matthis, Jesper Z. Haeggström · 2014 · Proceedings of the National Academy of Sciences
- Dietary Supplementation of Polyunsaturated Fatty Acids in Caenorhabditis elegansMarshall L. Deline, Tracy L. Vrablik, Jennifer L. Watts · 2013 · Journal of Visualized Experiments
- Soluble Epoxide HydrolaseNandita C. Gupta, Catherine M. Davis, Jonathan W. Nelson, Jennifer M. Young, Nabil J. Alkayed · 2012 · Arteriosclerosis Thrombosis and Vascular Biology
- Structural and functional basis of phospholipid oxygenase activity of bacterial lipoxygenase from Pseudomonas aeruginosaSwathi Banthiya, Jacqueline Kalms, Etienne Galemou Yoga, Igor Ivanov, X. Carpena, Mats Hámberg, Hartmut Kühn, Patrick Scheerer · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Cysteinyl Leukotrienes as Potential Pharmacological Targets for Cerebral DiseasesPaolo Gelosa, Francesca Colazzo, Elena Tremoli, Luigi Sironi, Laura Castiglioni · 2017 · Mediators of Inflammation
- Anti-Inflammatory Function of Fatty Acids and Involvement of Their Metabolites in the Resolution of Inflammation in Chronic Obstructive Pulmonary DiseaseStanislav Nikolaevich Kotlyarov, Анна Анатольевна Котлярова · 2021 · International Journal of Molecular Sciences
- Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell DeathLuke A. Farmer, Zijun Wu, Jia‐Fei Poon, Omkar Zilka, Svenja Lorenz, Stephanie Huehn, Bettina Proneth, Marcus Conrad, Derek A. Pratt · 2022 · Journal of the American Chemical Society
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- 4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP)Erden Banoğlu, Erşan Çelikoğlu, Susanna Völker, Abdurrahman Olğaç, Jana Gerstmeier, Ulrike Garscha, Burcu Çalışkan, Ulrich S. Schubert, Andrea Carotti, Antonio Macchiarulo et al. · 2016 · European Journal of Medicinal Chemistry
- Ferroptosis Is Regulated by Mitochondria in Neurodegenerative DiseasesJue-Pu Zhou, Yao Jin, Yu-Hong Lei, Tianyi Liu, Zheng Wan, Hao Meng, Honglei Wang · 2020 · Neurodegenerative Diseases
- Regression of human coronary artery plaque is associated with a high ratio of (18‐hydroxy‐eicosapentaenoic acid + resolvin E1) to leukotriene B 4Francine K. Welty, Fabian Schulte, Abdulhamied Alfaddagh, Tarec K. Elajami, Bruce Ryan Bistrian, Markus Hardt · 2021 · The FASEB Journal
- Dihydroartemisinin Induces Ferroptosis in HCC by Promoting the Formation of PEBP1/15‐LOYing Su, Danli Zhao, Chun Jin, Zhanghao Li, Sumin Sun, Siwei Xia, Yuxin Zhang, Zili Zhang, Feng Zhang, Xuefen Xu et al. · 2021 · Oxidative Medicine and Cellular Longevity
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- Metabolic Profiling Reveals Differences in Concentrations of Oxylipins and Fatty Acids Secreted by the Infrapatellar Fat Pad of Donors With End‐Stage Osteoarthritis and Normal DonorsLobke Marijn Gierman, Suzan Wopereis, Benno Van El, Elwin R. Verheij, Bianca J. C. van der Werff-van der Vat, Yvonne M. Bastiaansen-Jenniskens, Gerjo J.V.M. van Osch, M. Kloppenburg, Vedrana Stojanovic-Susulic, Tom W. J. Huizinga et al. · 2013 · Arthritis & Rheumatism
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- Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolaseUlrike Garscha, Erik Romp, Simona Pace, Antonietta Rossi, Veronika Temml, Daniela Schuster, Stefanie König, Jana Gerstmeier, Stefanie Liening, Markus Werner et al. · 2017 · Scientific Reports
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- Ferroptosis: regulated cell deathIvana Čepelak, Slavica Dodig, Daniela Čepelak Dodig · 2020 · Archives of Industrial Hygiene and Toxicology
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- Association of Arachidonic Acid-derived Lipid Mediators with Subsequent Onset of Acute Myocardial Infarction in Patients with Coronary Artery DiseaseChin‐Chou Huang, Meng-Ting Chang, Hsin‐Bang Leu, Wei‐Hsian Yin, Wei-Kung Tseng, Yen‐Wen Wu, Tsung‐Hsien Lin, Hung‐I Yeh, Kuan‐Cheng Chang, Ji‐Hung Wang et al. · 2020 · Scientific Reports
- Regulation of arachidonic acid oxidation and metabolism by lipid electrophilesAndrés Trostchansky, Irene Wood, Homero Rubbo · 2020 · Prostaglandins & Other Lipid Mediators
- Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega‐3 fatty acidsSusanna L. Lundström, Jun Yang, John Daniel Brannan, Jesper Z. Haeggström, Bruce D. Hammock, Parameswaran K. Nair, Paul M. O’Byrne, Sven‐Erik Dahlén, Craig Edward Wheelock · 2013 · Molecular Nutrition & Food Research
- Insights into the cardioprotective properties of n-3 PUFAs against ischemic heart disease via modulation of the innate immune systemAhmed M. Darwesh, Deanna K. Sosnowski, Tim YT. Lee, Hedieh Keshavarz-Bahaghighat, John M. Seubert · 2019 · Chemico-Biological Interactions