Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
Haeggström, Jesper Z., Funk, Colin D.·2011·Chemical Reviews
Cited by (897)
Items 501–600 of 897
- Regio‐ and Stereospecificity in the Oxygenation of Arachidonic Acid Catalyzed by Leu597 Mutants of Rabbit 15‐Lipoxygenase: A QM/MM StudyReynier Suardíaz, Laura Masgrau, José M. Lluch, Àngels González‐Lafont · 2014 · ChemPhysChem
- Mutagenesis of Sequence Determinants of Truncated Porcine ALOX15 Induces Changes in the Reaction Specificity by Altering the Catalytic Mechanism of Initial Hydrogen AbstractionPatricia Saura, Ilya Kaganer, Dagmar Heydeck, José M. Lluch, Hartmut Kühn, Àngels González‐Lafont · 2017 · Chemistry - A European Journal
- Knock-out of 5-lipoxygenase in overexpressing tumor cells—consequences on gene expression and cellular functionHannah Weisser, Tamara Göbel, G. Melissa Krishnathas, Marius Kreiß, Carlo Angioni, Duran Sürün, Dominique Thomas, Tobias Schmid, Ann‐Kathrin Häfner, Astrid Stefanie Kahnt · 2022 · Cancer Gene Therapy
- Investigating membrane-binding properties of lipoxygenases using surface plasmon resonanceDenise L. Rohlik, Ethan Patel, Nathaniel C. Gilbert, Adam R. Offenbacher, Brandon L. Garcia · 2023 · Biochemical and Biophysical Research Communications
- The association between the gene encoding 5-lipoxygenase activating protein and abdominal aortic aneurysmsRadjesh J. Bisoendial, Michael W.T. Tanck, Jonathan Golledge, Lysette N. Broekhuizen, Dink A. Legemate, Erik S.G. Stroes, Paul E. Norman · 2011 · Atherosclerosis
- N-1, C-3 substituted indoles as 5-LOX inhibitors—In vitro enzyme immunoaasay, mass spectral and molecular docking investigationsPalwinder Singh, Pooja · 2013 · Bioorganic & Medicinal Chemistry Letters
- Off-target effect of the cPLA2α inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulumBogeon Yun, HeeJung Lee, Heather Ewing, Michael H. Gelb, Christina C. Leslie · 2016 · Biochemical and Biophysical Research Communications
- Myxochelin‐Inspired 5‐Lipoxygenase Inhibitors: Synthesis and Biological EvaluationSebastian Schieferdecker, Stefanie König, Simona Pace, Oliver Werz, Markus Nett · 2016 · ChemMedChem
- 15-oxoeicosatetraenoic acid mediates monocyte adhesion to endothelial cellMA Guohua, Bing Pan, Sufen Ren, Caixia Guo, Yansong Guo, Lixin Wei, Lemin Zheng, Buxing Chen · 2017 · Lipids in Health and Disease
- Photoactivation provides a mechanistic explanation for pan-assay interference behaviour of 2-aminopyrroles in lipoxygenase inhibitionHao Guo, Nikolaos Eleftheriadis, Nataliya Rohr‐Udilova, Alexander S. S. Dömling, Frank J. Dekker · 2017 · European Journal of Medicinal Chemistry
- The Traditional Medicinal Plants Cuphea calophylla, Tibouchina kingii, and Pseudelephantopus spiralis Attenuate Inflammatory and Oxidative MediatorsAna María Ramírez-Atehortúa, Lorena Morales-Agudelo, Edison Osorio, Oscar Javier Lara-Guzmán · 2018 · Evidence-based Complementary and Alternative Medicine
- 12‐HETE/GPR31 induces endothelial dysfunction in diabetic retinopathyShuli Chen, Xinran Qin, Yu Sun, Zhenlin Ma, Chen Niu, Yi Xu, Lina Lu, Haidong Zou · 2024 · The FASEB Journal
- Macrophage-specific lipoxygenase deletion amplify cardiac repair activating Treg cells in chronic heart failureVasundhara Kain, Gabriel Araujo Grilo, Gunjan Upadhyay, Jerry L. Nadler, Charles Nicholas Serhan, Ganesh V. Halade · 2024 · Journal of Leukocyte Biology
- Investigating the Catalytic Site of Human 15‐Lipoxygenase‐1 via Marine Natural ProductsNtaniela Spacho, Marcello Casertano, Concetta Imperatore, Christos Papadopoulos, Marialuisa Menna, Nikolaos Eleftheriadis · 2024 · Chemistry - A European Journal
- Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activityPoorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar Shrivastava · 2024 · RSC Medicinal Chemistry
- Synthesis of site-specifically 13C labeled linoleic acidsAdam R. Offenbacher, Hui Zhu, Judith Pollock Klinman · 2016 · Tetrahedron Letters
- Purification and site-directed mutagenesis of linoleate 9 S -dioxygenase-allene oxide synthase of Fusarium oxysporum confirms the oxygenation mechanismYang Chen, Fredrik Jernerén, Ernst H. Oliw · 2017 · Archives of Biochemistry and Biophysics
- Identification of differential expression lncRNAs in gastric cancer using transcriptome sequencing and bioinformatics analysesYiyi Wang, Jue Zhang · 2018 · Molecular Medicine Reports
- Liquid chromatography-coupled mass spectrometry analysis of glutathione conjugates of oxygenated polyunsaturated fatty acidsStefanie Liening, Erik Romp, Oliver Werz, Gerhard K. E. Scriba, Ulrike Garscha · 2019 · Prostaglandins & Other Lipid Mediators
- On the Regio‐ and Stereospecificity of Arachidonic Acid Peroxidation Catalyzed by Mammalian 15‐Lypoxygenases: A Combined Molecular Dynamics and QM/MM StudyReynier Suardíaz, Laura Masgrau, José M. Lluch, Àngels González‐Lafont · 2013 · ChemPhysChem
- THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASEValérie Urbach, Gerard Higgins, Paul Buchanan, Fiona Ringholz · 2013 · Computational and Structural Biotechnology Journal
- Kinetic investigation of human 5-lipoxygenase with arachidonic acidMonica Mittal, Ramakrishnan Balakrishnan Kumar, Navisraj Balagunaseelan, Mats Hámberg, Caroline Jegerschöld, Olof Rådmark, Jesper Z. Haeggström, Agnes Rinaldo-Matthis · 2016 · Bioorganic & Medicinal Chemistry Letters
- Development of smart cell-free and cell-based assay systems for investigation of leukotriene C 4 synthase activity and evaluation of inhibitorsStefanie Liening, Gerhard K. E. Scriba, Silke Rummler, Christina Weinigel, Thea K. Kleinschmidt, Jesper Z. Haeggström, Oliver Werz, Ulrike Garscha · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Regulate the Disposition of Acacetin GlucuronidesHuangyu Jiang, Jia Hui Yu, Haihui Zheng, Jia‐Mei Chen, Jinjun Wu, Xiaoxiao Qi, Ying Wang, Xinchun Wang, Ming Hu, Lijun Zhu et al. · 2017 · Pharmaceutical Research
- Oxygenated lipid signaling in tumor-associated macrophages—focus on colon cancerJennifer K. Colby, Jonathan C. Jaoude, Fuyao Liu, Imad Shureiqi · 2018 · Cancer and Metastasis Reviews
- Engineered Substrate for Cyclooxygenase-2: A Pentapeptide Isoconformational to Arachidonic Acid for Managing InflammationBaljit Kaur, Manpreet Kaur, Navjot Kaur, Saweta Garg, Rajbir Bhatti, Palwinder Singh · 2019 · Journal of Medicinal Chemistry
- Molecular investigation of artificial and natural sweeteners as potential anti-inflammatory agentsEleni Chontzopoulou, Christina D. Papaemmanouil, Μaria V. Chatziathanasiadou, Dimitrios Kolokouris, Sofia Kiriakidi, Athina Konstantinidi, Ioanna Gerogianni, Theodore V. Tselios, Ioannis K. Kostakis, Evangelia D. Chrysina et al. · 2021 · Journal of Biomolecular Structure and Dynamics
- Tuft cell integration of luminal states and interaction modules in tissuesChristoph Schneider · 2021 · Pflügers Archiv - European Journal of Physiology
- Rational design of a large Stokes shift xanthene–benzothiozolium dyad for probing cysteine in mitochondriaSongtao Cai, Qiuchen Liu, Chang Xin Liu, Song He, Liancheng Zhao, Xianshun Zeng, Jin Dong Gong · 2022 · Journal of Materials Chemistry B
- Ferrostatin-1 alleviates the damage of C2C12 myoblast and mouse pelvic floor muscle induced by mechanical traumaYong He, Guotao Huang, Shasha Hong, Xiaohu Zuo, Zhihan Zhao, Hong Li · 2023 · Cell Death Discovery
- The biosynthetic pathways of the protectinsÅsmund Stenvik Haatveit, Trond Vidar Hansen · 2023 · Prostaglandins & Other Lipid Mediators
- Involvement of Lipids and Lipid Mediators in Inflammation and AtherogenesisStanislav Nikolaevich Kotlyarov · 2024 · Current Medicinal Chemistry
- Network toxicological analysis of sodium dehydroacetate in food safetyJing Jin, Xue Rui Yan, Liang Tian · 2025 · Food and Chemical Toxicology
- Cytokine-Dependent Expression Regulation of ALOX15Hartmut Kühn, Tatjana Gehring, Andrea Schroter, Dagmar Heydeck · 2016 · Journal of Cytokine Biology
- Origin of Regio- and Stereospecific Catalysis by 8-LipoxygenaseVipin Kumar Mishra, Sabyashachi Mishra · 2019 · The Journal of Physical Chemistry B
- The First Total Synthesis of the Lipid Mediator PD2n-3 DPAJørn Eivind Tungen, Karoline Gangestad Primdahl, Trond Vidar Hansen · 2020 · Journal of Natural Products
- Acute Coronary Syndrome May be Associated with Decreased Resolvin D1-to-Leukotriene B4 RatioChangqing Sun, Wuyang Zheng, Ling Liang, Ziguan Zhang, Zuheng Liu, Wenchao Sun, Jianwei Zhou, Weitong Qiao, Qiang Xie, Rong Tang · 2023 · International Heart Journal
- 12-HETE activates Müller glial cells: The potential role of GPR31 and miR-29Mohamed Tarek Moustafa, Abraham Khalil, Noureldien H. E. Darwish, Dao-Qi Zhang, Amany M. Tawfik, Mohamed Al‐Shabrawey · 2023 · Prostaglandins & Other Lipid Mediators
- Conformational Dynamics of Lipoxygenases and Their Interaction with Biological MembranesFulvio Erba, Giampiero Mei, Velia Minicozzi, Annalaura Sabatucci, Almerinda Di Venere, Mauro Maccarrone · 2024 · International Journal of Molecular Sciences
- LC-HRMS analysis of phospholipids bearing oxylipinsLaura Carpanedo, Katharina M. Rund, Luca M. Wende, Nadja Kampschulte, Nils Helge Schebb · 2024 · Analytica Chimica Acta
- Leukotriene enhanced allergic lung inflammation through induction of chemokine productionKihyuk Shin, Jung Joo Hwang, Bo‐In Kwon, Farrah Kheradmand, David Brian Corry, Seung‐Hyo Lee · 2014 · Clinical and Experimental Medicine
- Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemiaValeria Winslow, Rachel Vaivoda, Aleksandr Vasilyev, David Dombkowski, Karim Douaidy, Christopher M. Stark, Justin A. Drake, Evin L. Guilliams, Dharamainder Choudhary, Frederic I. Preffer et al. · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A 4 hydrolase aminopeptidase inhibitorsFan Zhang, Dang Wu, Gaolei Wang, Shuang Hou, Ping Ou-Yang, Jin Yan Huang, Xiaoyong Xu · 2016 · Chinese Chemical Letters
- The Mercapturomic Profile of Health and Non-Communicable DiseasesClara G. Dias, Judit Morelló, Valdir A. R. Semedo, Maria João Correia, Nuno R. Coelho, Emília Carreira Monteiro, Alexandra M. M. Antunes, Sofia Azeredo Pereira · 2019 · Microarrays
- 18F-Glutathione Conjugate as a PET Tracer for Imaging Tumors that Overexpress L-PGDS EnzymeHo-Lien Huang, Ying‐Cheng Huang, Wei-Yuan Lee, Chun‐Nan Yeh, Kun‐Ju Lin, Chung‐Shan Yu · 2014 · PLoS ONE
- QSAR modeling of benzoquinone derivatives as 5-lipoxygenase inhibitorsT.K. Shameera Ahamed, Vijisha K. Rajan, Karuvanthodi Muraleedharan · 2019 · Food Science and Human Wellness
- Acute psychosis with a mediastinal carcinoma metastasis.Carlos Schönfeldt‐Lecuona, Roland W. Freudenmann, Hayrettin Tumani, Jan Kassubek, Bernhard J. Connemann · 2005 · PubMed
- Ferroptosis in cardiovascular diseases: molecular mechanisms and a novel therapeutic targetSuli Yu, Zhen Pang, Hong Fang, Chi Liu · 2026 · Molecular Biomedicine
- Interaction between α-Synuclein and Bioactive Lipids: Neurodegeneration, Disease Biomarkers and Emerging TherapiesChiara Sanluca, P. Spagnolo, Romina Mancinelli, Maria Ilenia De Bartolo, Marina Fava, Mauro Maccarrone, Simone Carotti, Eugenio Gaudio, Alessandro Leuti, Giorgio Vivacqua · 2024 · Metabolites
- Dysregulation of the Arachidonic Acid Pathway in Cystic Fibrosis: Implications for Chronic Inflammation and Disease ProgressionSimona D’Orazio, Domenico Mattoscio · 2024 · Pharmaceuticals
- Thread-Based Bienzymatic Biosensor for Linoleic Acid DetectionJacopo Giaretta, Farshad Oveissi, Sina Naficy, Syamak Farajikhah, Fariba Dehghani · 2024 · ACS Omega
- Antioxidant, Hypotensive, and Antidiabetic Breakthroughs: Bromelain Hydrolysis Unlocks Quinoa’s Peptide Potential - In Silico and In Vitro ApproachMaría Lilibeth Manzanilla‐Valdez, Sarita Montaño, Cristina Martínez‐Villaluenga, Fernanda Zúñiga, Christine Boesch, Alan Javier Hernández‐Álvarez · 2025 · Journal of Agricultural and Food Chemistry
- Arachidonic acid fuels inflammation by unlocking macrophage protein phosphatase 5 after myocardial infarctionZhipeng Chen, Jiawei Song, Suli Feng, Mingming Liu, Yan Zhang, Xilin Shen, Ting Zhou, Zhong Xian, Hongfeng Jiang, Chen Chen et al. · 2025 · European Heart Journal
- Increased serum 12-hydroxyeicosatetraenoic acid levels are correlated with an increased risk of diabetic retinopathy in both children and adults with diabetesShuli Chen, Qian Yu, Qiurong Lin, Zhangling Chen, Zhaoyu Xiang, Lipu Cui, Jiaqi Sun, Xinran Qin, Yi Xu, Lina Lu et al. · 2022 · Acta Diabetologica
- Polychrome labeling reveals skeletal triradiate and elongation dynamics and abnormalities in patterning cue-perturbed embryosAbigail E. Descoteaux, Daniel T. Zuch, Cynthia A. Bradham · 2023 · Developmental Biology
- Structure and Inhibition of Mouse Leukotriene C4 SynthaseDamian Niegowski, Thea K. Kleinschmidt, Shabbir Ahmad, Abdul Aziz Qureshi, Michaela Marback, Agnes Rinaldo-Matthis, Jesper Z. Haeggström · 2014 · PLoS ONE
- Arachidonic acid metabolism in the human placenta: Identification of a putative lipoxygenaseAyesha Jadoon, Phil Cunningham, Lindsay McDermott · 2014 · Placenta
- Principles, Mechanisms of Action, and Future Prospects of Anti-inflammatory DrugsBibiana Rius, Joan Clària · 2016 · Springer eBooks
- Targeting cysteinyl-leukotrienes in abdominal aortic aneurysmAna Carolina Justino de Araújo, Xiao Yan Tang, Jesper Z. Haeggström · 2018 · Prostaglandins & Other Lipid Mediators
- Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15Igor Ivanov, Alejandro Cruz, Alexander V. Zhuravlev, Almerinda Di Venere, Eleonora Nicolai, Sabine Stehling, José M. Lluch, Àngels González‐Lafont, Hartmut Kühn · 2021 · International Journal of Molecular Sciences
- Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation ModelsMarjann Schäfer, Florian Reisch, Dominika Łabuz, Halina Machelska, Sabine Stehling, Gerhard P. Püschel, Michael Rothe, Dagmar Heydeck, Hartmut Kühn · 2023 · International Journal of Molecular Sciences
- Phosphorylation mimicking mutations of ALOX5 orthologs of different vertebrates do not alter reaction specificities of the enzymesSusan Adel, Katharina Hofheinz, Dagmar Heydeck, Hartmut Kühn, Ann‐Kathrin Häfner · 2014 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Nonsteroidal Anti-Inflammatory Drugs: Exploiting Bivalent COXIB/ TP Antagonists for the Control of Cardiovascular RiskSilvia Carnevali, Carola Buccellati, Chiara Bolego, Massimo Bertinaria, G. Enrico Rovati, Angelo Sala · 2017 · Current Medicinal Chemistry
- Paradoxical Effect of LTB4 on the Regulation of Stress-Induced Corticosterone ProductionGisele Aparecida Locachevic, Morgana Kelly Borges Prado, Karina Furlani Zoccal, Priscilla Aparecida Tártari Pereira, Carlos A. Sorgi, Mariza Bortolanza, Ana Paula Ferranti Peti, Manoela V. Fogaça, Francisco Silveira Guimarães, Elaine Del Bel et al. · 2019 · Frontiers in Behavioral Neuroscience
- The role of the 12(S)-HETE/GPR31/12-HETER axis in cancer and ischemia–reperfusion injuryMonica Napolitano · 2019 · Biochemical Society Transactions
- Chemoprevention of breast cancer by cyclooxygenase and lipoxygenase inhibitorsRandall E. Harris, Joanne Beebe-Donk, Judith Schwartzbaum · 2020 · World Academy of Sciences Journal
- The IRE1α Inhibitor KIRA6 Blocks Leukotriene Biosynthesis in Human PhagocytesXiao Yan Tang, Tarvi Teder, Bengt O. Samuelsson, Jesper Z. Haeggström · 2022 · Frontiers in Pharmacology
- Improved catalytic performance and molecular insight for lipoxygenase from Enterovibrio norvegicus via directed evolutionBingjie Zhang, Huibing Chi, Juan Shen, Yang Tao, Zhaoxin Lu, Fengxia Lü, Zhu Ping · 2023 · Frontiers in Bioengineering and Biotechnology
- Ferroptosis and retinal ganglion cell death in glaucoma: Mechanisms and therapeutic approachesMinggao Qin, Xueqin He, Weiwen Qiu, Yanjing Peng, Yushan Liao, Jusen Zhao, Lianxiang Luo, Qiuli Zhang · 2025 · Journal of Pharmaceutical Analysis
- Decoding the spatiotemporal characteristics of ferroptosis: reshaping tumour therapeutic strategiesLizhou Song, Yue Shu, Tian Zhou, Yi Wang, Haoling Zhang, Yan Liao, Chenglong Zhu, Wangzheqi Zhang, Zui Zou · 2026 · Experimental Hematology and Oncology
- IL-33 Upregulates Cysteinyl Leukotriene Receptor Type 1 Expression in Human Peripheral Blood CD4+ T LymphocytesMarie Boudaud, Sylvie Turcotte, Jana Staňková, Marek Rola‐Pleszczynski · 2018 · The Journal of Immunology
- 13C Electron Nuclear Double Resonance Spectroscopy-Guided Molecular Dynamics Computations Reveal the Structure of the Enzyme–Substrate Complex of an Active, N-Linked Glycosylated LipoxygenaseAjay Sharma, Chris Whittington, Mohammed A. Jabed, S. Gage Hill, Anastasiia Kostenko, Tao Yu, Pengfei Li, Peter E. Doan, Brian M. Hoffman, Adam R. Offenbacher · 2023 · Biochemistry
- Impact of myeloperoxidase-derived oxidants on the product profile of human 5-lipoxygenaseJosefin Zschaler, Juliane Dorow, Louisa Schöpe, Uta Ceglarek, Jürgen Arnhold · 2015 · Free Radical Biology and Medicine
- Combined Autodock and comparative molecular field analysis study on predicting 5-lipoxygenase inhibitory activity of flavonoids isolated from Spatholobus suberectus DunnShiyun Jiang, Kai Huang, Wen Liu, Fengming Fu, Jie Xu · 2015 · Zeitschrift für Naturforschung C
- 5-lipoxygenase-dependent biosynthesis of novel 20:4 n-3 metabolites with anti-inflammatory activityK.J. Gagnon, Natalie Lefort, Samuel J. Poirier, David A. Barnett, Marc E. Surette · 2018 · Prostaglandins Leukotrienes and Essential Fatty Acids
- Metabolism and biological functions of 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acidToshiaki Okuno, Takehiko Yokomizo · 2020 · Prostaglandins & Other Lipid Mediators
- Metabolic systems analysis identifies a novel mechanism contributing to shock in patients with endotheliopathy of trauma (EoT) involving thromboxane A2 and LTC4H Henriksen, Igor Marín de Mas, Helena Herand, Joseph D. Krocker, Charles E. Wade, Pär I. Johansson · 2022 · Matrix Biology Plus
- Characterization and Preliminary Application of a Novel Lipoxygenase from Enterovibrio norvegicusBingjie Zhang, Meirong Chen, Bingjie Xia, Zhaoxin Lu, Kuan Shiong Khoo, Pau Loke Show, Fengxia Lü · 2022 · Foods
- Lipoxygenase inhibitory activity ofCuspidaria pulchraand isolated compoundsTavane Aparecida Alvarenga, Camila Spereta Bertanha, Pollyanna F. de Oliveira, Denise Crispim Tavares, Valéria Maria Melleiro Gimenez, Márcio Luís Andrade e Silva, Wilson Roberto Cunha, Ana Helena Januário, Patrícia Mendonça Pauletti · 2014 · Natural Product Research
- Leprosy and its reactional episodes: Serum levels and possible roles of omega-3 and omega-6-derived lipid mediatorsCristiana Santos de Macedo, Fernanda Marques de Carvalho, Julio J. Amaral, Soraya de Mendonça Ochs, Edson Fernandes de Assis, Euzenir Nunes Sarno, Patrícia Torres Bozza, María Cristina Vidal Pessolani · 2018 · Cytokine
- Discovery of Novel Ortho-Aminophenol Derivatives Targeting Lipid Peroxidation with Potent Antiferroptotic ActivitiesX. D. Sheng, Li-Cong Han, Ao Gong, Xiang‐Shuai Meng, Xinhui Wang, Lin-Song Teng, Xiaohan Sun, Kuo-Chen Xu, Zhaohua Liu, Ting Wang et al. · 2024 · Journal of Medicinal Chemistry
- Anti-inflammatory Principles of the Plant Family AmaryllidaceaeJerald J. Nair, Johannes Van Staden · 2024 · Planta Medica
- FGF8 promotes lipid droplet accumulation via the FGFR1/p-p38 axis in chondrocytesMinglei Huang, Haoran Chen, Jieya Wei, Caixia Pi, Mengmeng Duan, Xiaohua Pu, Zhixing Niu, Siqun Xu, Shasha Tu, Sijun Liu et al. · 2025 · Acta Biochimica et Biophysica Sinica
- In Vitro Cytostatic Effect on Tumor Cells by Carborane‐Based Dual Cyclooxygenase‐2 and 5‐Lipoxygenase InhibitorsSebastian Braun, Svetlana Paskaš, Markus Laube, Sven George, Bettina Hofmann, Peter Lönnecke, Dieter Steinhilber, Jens Pietzsch, Sanja Mijatović, Danijela Maksimović‐Ivanić et al. · 2022 · Advanced Therapeutics
- Synthesis and In Vitro Biological Evaluation of p-Carborane-Based Di-tert-butylphenol AnalogsSebastian Braun, Sanja Jelača, Markus Laube, Sven George, Bettina Hofmann, Peter Lönnecke, Dieter Steinhilber, Jens Pietzsch, Sanja Mijatović, Danijela Maksimović‐Ivanić et al. · 2023 · Molecules
- Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 HydrolaseGebhard Thoma, Christian Märkert, Rainer M. Lueoend, Wolfgang Miltz, Carsten Spanka, Birgit Bollbuck, Romain M. Wolf, Honnappa Srinivas, Carlos A. Penno, Michael Kiffe et al. · 2023 · Journal of Medicinal Chemistry
- Interactions between 5-Lipoxygenase Polymorphisms and Adipose Tissue Contents of Arachidonic and Eicosapentaenoic Acids Do Not Affect Risk of Myocardial Infarction in Middle-Aged Men and Women in a Danish Case-Cohort StudyAnders Gammelmark, Søren Lundbye‐Christensen, Anne Marie Tjønneland, Erik Berg Schmidt, Kim Overvad, Michael S. Nielsen · 2017 · Journal of Nutrition
- Differential immune response to Eimeria maxima infection in fast‐ and slow‐growing broiler genotypesTim Giles, Panagiotis Sakkas, Aouatif Belkhiri, Paul Barrow, Ilias Kyriazakis, Neil M. Foster · 2019 · Parasite Immunology
- Lipoxygenases as Targets for Drug DevelopmentXiao‐Yuan Mao · 2019 · Methods in molecular biology
- Classification models and SAR analysis on CysLT1 receptor antagonists using machine learning algorithmsHongzhao Wang, Zijian Qin, Aixia Yan · 2021 · Molecular Diversity
- Mechanistic insights into 5-lipoxygenase inhibition by pyocyanin: a molecular docking and molecular dynamics studySaibharath Simha Reddy Santha, A. S. Vishwanathan · 2021 · Journal of Biomolecular Structure and Dynamics
- Resolvin D1 reduces expression and secretion of cytokines and monocyte adhesion triggered by Angiotensin II, in rat cardiac fibroblastsAimeé V. Salas-Hernández, Felipe Ruz-Cortés, Francisca Brüggendieck, Claudio Espinoza-Pérez, Jenaro Espitia-Corredor, Nelson Varela, Luis A. Quiñones, Carlos F. Sánchez‐Ferrer, Concepción Peiró, Guillermo Dı́az-Araya · 2021 · Biomedicine & Pharmacotherapy
- Identification of a Bromodomain‐like Region in 15‐Lipoxygenase‐1 Explains Its Nuclear LocalizationDeng Chen, Zhangping Xiao, Hao Guo, Dea Gogishvili, Rita Setroikromo, Petra E. van der Wouden, Frank J. Dekker · 2021 · Angewandte Chemie International Edition
- Targeting cellular energy metabolism- mediated ferroptosis by small molecule compounds for colorectal cancer therapyGang Wang, Junjie Wang, Xiao-Na Xu, Feng Shi, Xing-Li Fu · 2022 · Journal of drug targeting
- Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoidsXiao Yan Tang, Yaolin Hou, Thue Walter Schwartz, Jesper Z. Haeggström · 2022 · Biochemical Pharmacology
- Diversity of the manganese lipoxygenase gene family – A mini-reviewErnst H. Oliw · 2022 · Fungal Genetics and Biology
- Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapyHongxia Chen, Luxi Yin, Jie Yang, Ningxin Ren, Jinna Chen, Qixuan Lu, Ying Sheng Huang, Yanru Feng, Weihu Wang, Shulian Wang et al. · 2023 · Cancer Biology and Medicine
- Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic systemFlorian Reisch, Dagmar Heydeck, Marjann Schäfer, Michael Rothe, Jiaxing Yang, Sabine Stehling, Gerhard P. Püschel, Hartmut Kühn · 2023 · Cellular & Molecular Biology Letters
- Identification of the Thermal Activation Network in Human 15-Lipoxygenase-2: Divergence from Plant Orthologs and Its Relationship to Hydrogen Tunneling Activation BarriersAmanda R. Ohler, P. E. Taylor, Jasmine A. Bledsoe, Anthony T. Iavarone, Nathaniel C. Gilbert, Adam R. Offenbacher · 2024 · ACS Catalysis
- CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5aRachel Vaivoda, Christine A. Vaine, Cassandra Boerstler, Kristy Galloway, Peter Christmas · 2015 · Journal of Immunology Research