Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease

Cited by (897)

Items 801–897 of 897

1. NETWORK DOS MEDIADORES LIPÍDICOS COM DOENÇAS AUTOIMUNES: UMA REVISÃO DE LITERATURA
   Danielle Cristina Pereira, Débora Oléa Braga, Laura Ballalai Swenson, Martha Laura Simão Silva, Myriam Victória Monteiro Frota, Karina Furlani Zoccal · 2021 · RECIMA21 - Revista Científica Multidisciplinar
2. The Role of Subterminal Hydroxyeicosatetraenoic Acids in the Pathogenesis of Cardiac Hypertrophy
   Sherif M. Shoieb · 2021 · ERA: Education and Research Archive (University of Alberta)
3. Discovery of Novel Fatty Acid Dioxygenases and Cytochromes P450 : Mechanisms of Oxylipin Biosynthesis in Pathogenic Fungi
   Inga Hoffmann · 2013 · Uppsala University Publications (Uppsala University)
4. Lipids
   Ibrahim Guillermo Castro‐Torres, Víctor Alberto Castro‐Torres, Minerva Hernández-Lozano, Marcos Fernando Ocaña-Sánchez · 2021 · Springer eBooks
5. Metabólitos da 15-lipoxigenase influenciam crescimento, migração e potencial invasivo de células de glioblastoma.
   Matthew Thomas Ferreira · 2020
6. Oxylipins: Role in Stem Cell Biology
   Helike Lõhelaid, Tarvi Teder · 2022 · MDPI eBooks
7. Ferroptosis a Futuristic Roadmap for Cancer and Alzheimer's Disease
   Gourav Singh, Prashant Kesharwani, Bhupendra Kumar, Indubhusan Mishra, Saroj Kumar, Gyan Prakash Modi · 2022 · SSRN Electronic Journal
8. Identification of Novel Triazole Based Indoles as Lead Molecules against Enzyme Mediated Inflammation
   2016 · Chemical Science Transactions
9. Enzymes | Lipoxygenases and Their Downstream Oxylipin Products: Harnessing Nature’s Chemical Diversity for Applications in Medicine and Industry
   Marcia E. Newcomer, Svetlana V. Pakhomova, Nathaniel C. Gilbert · 2020 · Elsevier eBooks
10. Model for metabolism of arachidonic acid by 5-lipoxygenase as 5, 6-LTA4 synthase in the sheep uterus: Evidence from in vitro studies
    A. Sai Padma, K. Anil Kumar, P. Reddanna · 2022 · Journal of Applied Biology & Biotechnology
11. Long COVID and postcovid syndrome as a multidisciplinary problem
    Ж.В. Антонович · 2022 · Рецепт
12. 13 C ENDOR Spectroscopy-Guided MD Computations Reveals the Structure of the Enzyme-Substrate Complex of an Active, N-linked Glycosylated Lipoxygenase
    Ajay Sharma, Chris Whittington, Mohammed A. Jabed, S. Gage Hill, Anastasiia Kostenko, Tao Yu, Pengfei Li, Brian M. Hoffman, Adam R. Offenbacher · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
13. Influence of the CRISPR/Cas mediated knockout of 5-Lipoxygenase on tumour cells
    Hannah Weisser · 2022
14. Data from Leukotriene Synthesis Is Critical for Medulloblastoma Progression
    Fang Du, Larra W. Yuelling, Eric H. Lee, Yuan Wang, Shengyou Liao, Yan Cheng, Li Zhang, Chaonan Zheng, Suraj Peri, Kathy Qi Cai et al. · 2023
15. ALOX5 and ALOX5AP as an mRNA metric predicts unfavorable prognosis in lower-grade glioma
    Zhang Ping, Yujing Han, Yu Zhang · 2023 · Research Square
16. The effect of eight weeks of high-intensity interval training and moderate-intensity continuous training on some factors causing oxidative stress in the cardiomyocytes of mice with type II diabetes
    Ali Khosravi Zadeh, Rahmaninia Farhad, Arsalan Damirchi, Mehdi Kargarfard · 2023 · Journal of Shahrekord University of Medical Sciences
17. Ferroptosis Modulators: A Potential Therapeutic Target in Alzheimer’s Disease
    Gourav Singh, Nishant Kumar Rana, Indubhusan Mishra, Gyan Prakash Modi · 2023 · Springer eBooks
18. Synthesis and biological characterization of esterified lipid mediators
    Bjarne Goebel · 2024
19. Mechanisms and Preventive Measures of Aldh2 in Ischemia-Reperfusion Injury: Ferroptosis as a Novel Target
    Liang Han, Wen Zhai · 2024 · SSRN Electronic Journal
20. Metabólitos da 15-lipoxigenase influenciam crescimento, migração e potencial invasivo de células de glioblastoma.
    Matthew Thomas Ferreira · 2019
21. Key markers of ferroptosis
    Maria D. Tokhtueva, Vsevolod V. Melekhin · 2024 · Molekulyarnaya Meditsina (Molecular medicine)
22. PEDV infection induces ferroptosis in Vero cells via an ACSL-mediated lipid peroxidation pathway
    Qian Weng, Yuheng Li, Yuze Wei, Simin Wang, Tingyu Hu, Zhihua Pei, Kai Wang, Guixue Hu · 2024 · Research Square
23. Análise de proteínas de leucócitos polimorfonucleares de gatos domésticos
    Gabriela Mota Sena de Oliveira, Irma Yuliana Mora-Ocampo, Carlos Priminho Pirovani, José Luís Meneses Varjão, Alexandre Dias Munhoz · 2024 · Semina Ciências Agrárias
24. Vasoactive Substances as Mediators of Renal Injury
    Paulo Sebastian Caceres, Noreen F. Rossi · 2025 · Elsevier eBooks
25. Hybrid pharmacophore-based design of novel 5-lipoxygenase inhibitors: Molecular docking and dynamics simulation studies
    Jiangmiao Pang, Kit‐Kay Mak, Mallikarjuna Rao Pichika, Vasudeva Rao Avupati · 2025 · Results in Materials
26. Targeting oxygenases could be a viable anti-metastatic approach in cancer therapy
    Pengfei Shi, Jie Xu, Hongjuan Cui · 2025 · International Journal of Biological Macromolecules
27. Antifungal Volatile Organic Compounds from Talaromyces purpureogenus CEF642N: Insights from One Strain Many Compounds (OSMAC) Strategy for Controlling Verticillium dahliae in Cotton
    Peng Li, Yalin Zhang, Hongjie Feng, Jinglong Zhou, Lihong Zhao, Heqin Zhu, Feng Wei, Zili Feng · 2025 · Journal of Fungi
28. Plasma leukotriene B 4 decreases after bariatric–metabolic surgery in severe obesity: A prospective observational study
    Seiji Nishikage, Yushi Hirota, Yasushi Nakagawa, Masakazu Shinohara, Yusei Hosokawa, Shinsuke Nakajima, Kai Yoshimura, Akane Yamamoto, Tomofumi Takayoshi, Seiichi Kitahama et al. · 2025 · Diabetes Obesity and Metabolism
29. Structural basis for ATP regulation of human 5-lipoxygenase
    Tarvi Teder, Federico Pozzani, Tim Paul Schulte, A. Hosseini, Olof Rådmark, Laura Orellana, Jesper Z. Haeggström · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
30. Identification and Validation of Differentially Expressed mRNAs From Peripheral Leukocytes for Acute Stanford Type A Aortic Dissection
    Yueyun Zhou, C N Chen, Jian Li, Tong Jing, Aizeretiaili Maimaiti, Dongliang Chen, Song Yang, Junxiang Sun, Wen Chen, Xin Chen et al. · 2025 · Journal of the American Heart Association
31. Comparing the Thermodynamic Properties and Reactivity of Fe III - and Mn III –Hydroxo Complexes
    Anagha Puthiyadath, Timothy A. Jackson · 2025 · Inorganic Chemistry
32. Molecular insights into ago-allosteric modulation at cysteinyl leukotriene receptor 2
    Mu Li, Xiaoling Bao, Wanbiao Chen, Yusheng Guo, Xiaomin Mao, Miaofang Xiao, Siqi Liu, Jiawei Li, Limin Zhao, Tiancai Chang et al. · 2025 · Nature Communications
33. Additional file 1 of Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
    Florian Reisch, Dagmar Heydeck, Marjann Schäfer, Michael Rothe, Jiaxing Yang, Sabine Stehling, Gerhard P. Püschel, Hartmut Kühn · 2024 · Figshare
34. Additional file 1 of Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth
    Zhao, Hongting, Zhang, Meng, Zhang, Jinghua, Zichen Sun, Wenxin Zhang, Dong, Weichen, Cheng, Chen, Yongzhong Yao, Kuanyu Li · 2023 · Figshare
35. Relation of Serum 5‐LOX, Angiotensin Macromolecules, and Some Biochemical Parameters Levels in Renal Failure Patients
    Nibras Fadhel Ismail, Nadia Ahmed Saleh · 2025 · Macromolecular Symposia
36. Synthesis, characterization, and biological evaluation as inhibitors of 5-hLOX / COX-2 of 2-hydroxy-benzylidene-cymanthrenyl-sulfonylhydrazone ligand and its coordination entities
    Miguel Gallardo, Roberto Sanchez, Rodrigo Arancibia González, David Villaman, Patricia M. Toro, Elizabeth Navarrete, Pilar Morales, Carolina Mascayano · 2025 · SSRN Electronic Journal
37. The Inflammatory Roles of n-3 and n-6 Polyunsaturated Fatty Acids in COPD: Clinical Implications and Underlying Mechanisms
    Yingqi Wang, Yidie Bao, Boya Liu, Hui Li, Hongxia Duan, Yide Wang, Jiachi Zhang, Weibing Wu, Peijun Li, Xiaodan Liu · 2026 · Journal of Inflammation Research
38. Isolation and Biophysical Characterization of Lipoxygenase-1 from Soybean Seed, a Versatile Biocatalyst for Industrial Applications
    Ioanna Gerogianni, Antiopi Vardaxi, Ilias Matis, Maria Karayianni, Maria Zoumpanioti, Thomas Mavromoustakos, Stergios Pispas, Evangelia D. Chrysina · 2026 · Biomolecules
39. ANTI-INFLAMMATORY AND ANTI-HEMORRHOIDAL ACTIVITY OF POLYHERBAL GEL WITH THEIR CHARACTERIZATION USING CROTON OIL-INDUCED MODEL AND IN-SILICO ACTIVITY AGAINST INFLAMMATORY MEDIATORS
    ISHAN AGGARWAL, Sukirti Upadhyay, ARVIND KUMAR · 2025 · International Journal of Applied Pharmaceutics
40. Structure-Based Virtual Screening for ALOX5 Inhibitors: Combining Scaffold Hopping and Pharmacophore Approaches
    Xiao Li, Liang Li, Na Zhang, Linxin Wang, Lianxiang Luo · 2026 · Targets
41. Implementation of the FENIX assay to assess the anti-ferroptotic properties of test compounds
    Juliana A. Hüther, Melodie Mallais, Markus Rehm, Derek A. Pratt · 2026 · Methods in cell biology
42. Anti-inflammatory and antioxidant activities and nitric oxide inhibition of acetone extracts of three Algerian Saharan medicinal plants in LPS-stimulated RAW 264.7 Cells
    Manal LAKAS, Ibrahim Sifi, Jacobus Nicolaas Eloff · 2026 · European Journal of Integrative Medicine
43. PEDV infection induces ferroptosis in Vero cells via an ACSL4-mediated lipid peroxidation pathway
    Qian Weng, Yuheng Li, Yuze Wei, Simin Wang, TingYu Hu, Zhihua Pei, Kai Wang, Guixue Hu · 2026 · Archives of Virology
44. A Multistep Computational Approach to Achieve a Complete Human 5‐Lipoxygenase Structure and Provide a Pharmacophore Model for Further Drug Design
    Lisa Lombardo, Francesco Agnello, Rosaria Gitto, Laura De Luca · 2026 · Molecular Informatics
45. Schleichera oleosa Bark Extract Shows Potent Anti‐Arthritic Activity in Complete Freund's Adjuvant (CFA)‐Induced Arthritis in Rats and Network Pharmacology
    Yogita B. Tandalekar, Shreyanshi Kulshreshtha, Bhawana Jangra, Alok Goyal, Sanjay M. Jachak · 2026 · Chemistry & Biodiversity
46. Mobilisation de l'acide arachidonique et sensibilité au peptide ß-amyloïde
    Mélanie H. Thomas · 2015 · theses.fr (ABES)
47. Network Analysis of Convergent and Specific Molecular Pathways of Nutraceuticals with Antioxidant and Neuroprotective Potential in Glaucoma
    Pavlina Teneva, Sylvia Stamova, Kaloyan Varlyakov, Neli Ermenlieva, Emilia Petrova Georgieva, Todorka I. Kostadinova · 2026 · Antioxidants
48. Extraction et évaluation des propriétés biologiques des ulvanes et oligo-ulvanes de l'algue verte Ulva sp. : actions sur le métabolisme de cellules cutanées et sur le microbiote cutané
    Mathilde Fournière · 2021
49. Phytochemical Profiling and In Vitro Lipoxygenase Inhibitory Activity of Three Kratom Leaf Varieties by GC–MS, HPLC, and LC–HRMS
    Bujaningrum Ega Agustina, Berna Elya, Roshamur Cahyan Forestrania, Husniati Husniati · 2026 · Journal of Multidisciplinary Applied Natural Science
50. Harnessing the chemical reactivity of metals and related supramolecular structures in cancer cells and inflammation
    Leeroy Baron · 2024 · theses.fr (ABES)
51. Scoparone alleviates cisplatin-induced acute kidney injury by inhibiting 5-lipoxygenase-mediated ferroptosis
    Congcong Dai, Shuting Huang, Na Huang, Suwan Mu, Suwang Liu, Minhui Xie, Jing Mei, Yuhong Tang, Honghao Yu, Pengpeng Yue et al. · 2026 · Toxicology and Applied Pharmacology
52. Terapötik Hedef Enzimlerde (MAO, LOX, COX, ACE, Üreaz) Erişim Tünelleri ve Ligand Çıkış Yollarının Haritalanması: Doğal Ürün Kaynaklı İnhibitörlere Odaklanan Sistematik Bir Derleme
    Ayşenur Özer, Zafer Ömer Özdemir · 2026 · Bütünleyici ve Anadolu Tıbbı Dergisi
53. Structure-based identification of GIRK2–PIP2 modulators: Integrative docking, MM-GBSA, ADMET, and molecular dynamics study
    Danko Jeremic, Lydia Jiménez‐Díaz, Juan D. Navarro‐López · 2026 · Journal of Molecular Graphics and Modelling
54. Combined computational and experimental studies reveal an altered regiospecific switch in 5-lipoxygenase targeted by AKBA
    Sahanawaz Parvez, Markus Werner, Bill J Perkowski, Alrun Schumann, Oliver Werz, Polamarasetty Aparoy · 2026 · Biochemical and Biophysical Research Communications
55. Discovery of anti-inflammatory cardioprotective components interfering with eicosanoid metabolism from Sini decoction via correlation analysis between plasma chemical components and eicosanoid profiles
    Junli Liang, Cuiping Long, Xin Ding, Hongrui Ma, Ping Li, Runuo Wang, Qian Zhou, Guangguo Tan · 2026 · Microchemical Journal
56. A Thin-Layer Chromatography Bioautographic Assay for the Rapid Detection of Arachidonate 5-Lipoxygenase Inhibitors
    Aurélie Urbain, Yohan Paille, Maria Meidani, Souaibou Yaouba, Lucile Berthomier, César Cotte, Valérie Bardot · 2026 · Analytica—A Journal of Analytical Chemistry and Chemical Analysis
57. Immunomodulatory effect of squid ink extract on lipoxygenase pathways and MIH gene in Litopenaeus vannamei under different salinity condition
    Mohamad Fadjar, Sri Andayani, H. Kuhn, Diana Aisyah, Ayu Winna Ramadhani, Cucun Herlina · 2026 · Brazilian Journal of Biology
58. Signaling lipids: An overview of emerging physiological functions
    Ojal Saharan, Tathagata Pal, Siddhesh S. Kamat · 2026 · Current Opinion in Cell Biology
59. Light‐Controlled Modulation of 15‐Lipoxygenase‐1 Regulates Intestinal Inflammatory Signaling
    Anastasia Louka, Eirini-Eleni Kalaitzaki, Athanasios Panousis, Sotirios Bonoras, Charalampos G. Livas, George E. Froudakis, Ioannis Drygiannakis, Athina Damianaki, George C. Kolios, Vassilis Valatas et al. · 2026 · Angewandte Chemie
60. Light‐Controlled Modulation of 15‐Lipoxygenase‐1 Regulates Intestinal Inflammatory Signaling
    Anastasia Louka, Eirini-Eleni Kalaitzaki, Athanasios Panousis, Sotirios Bonoras, Charalampos G. Livas, George E. Froudakis, Ioannis Drygiannakis, Athina Damianaki, George C. Kolios, Vassilis Valatas et al. · 2026 · Angewandte Chemie International Edition
61. Tocotrienol metabolites redirect lipid mediator production in innate immune cells towards inflammation resolution
    Stephan Permann, Elena Brunner, Khaled Alsabil, Markus Werner, Lorenz Waltl, Guillaume Viault, Danilo D’Avino, Bill J Perkowski, Anita Siller, Laura Fritsch et al. · 2026 · Acta Pharmaceutica Sinica B
62. Vibrio parahaemolyticusAHPND infection altered eicosanoid biosynthesis in the gastrointestinal tract of Litopenaeus vannamei
    Wananit Wimuttisuk, Pisut Yotbuntueng, Pacharawan Deenarn, Punsa Tobwor, Surasak Jiemsup, Suganya Yongkiettrakul, Kamonluk Kittiwongpukdee, Siriwan Khidprasert, Chanadda Kasamechotchung, Kitlada Srichomthong et al. · 2026 · Biochemistry and Biophysics Reports
63. 8-Iso-Prostaglandin F2α and Lipoxygenase Gene Expression as Candidate Molecular Markers of Training Adaptation in Professional Volleyball Players: A Pilot Study
    Krystian Baran, Rafał Podgórski, Michalina Grzesik, Wojciech Czarny, Paweł Król, Julia Połeć, Élvio Rúbio Gouveia, Marek Cieśla · 2026 · International Journal of Molecular Sciences
64. Attenuation of liver fibrosis by platelet-type 12S-lipoxygenase expressed in hepatic stellate cells involves repression of platelet-derived growth factor receptors
    桂介 戸田, Rena Tamai, Ryoma Tanaka, Nanomi Araki, Maho Ishihara, Hibiki Kanji, Izumi Tsukayama, Yuki Kawakami, Toshiko Suzuki-Yamamoto, Yoshitaka Takahashi · 2026 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
65. Luteolin Attenuates Hypoxia-Induced Ferroptosis in Human Brain Microvascular Endothelial Cells Through Modulation of the PPARγ/FABP5/ALOX15 Signaling Pathway
    Sirirak Mukem, Patcharakorn Kiatamornrak, Saowaros Suwansa‐ard, Tipsuda Thongbuakaew · 2026 · Biomedicines
66. Unravelling Ferroptosis in Sepsis: A Comprehensive Integrative Transcriptomic Analysis Across Age and Disease Severity
    Miguel Victor Bringel Sales, Helder Imoto Nakaya, Fernando de Queiroz Cunha, Antônio Edson Rocha Oliveira · 2026 · Bioinformatics and Biology Insights
67. The functional diversification of somatosensory neuron repertoires across Mammalia
    S. Andrew Shuster, Jia Yin Xiao, Bruno Gegenhuber, Shamsuddin A. Bhuiyan, Min Dai, Yongting Chen, Michelle M. DeLisle, Preston Sheng, Elizabeth Howell, Michael Brecht et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
68. A molecular modeling and machine learning–based approach for the identification of potential human ALOX15 inhibitors
    Sonam Grewal, Biswayan Ghosh, Roy Karnati, Tanneru Hemanth Kumar, Polamarasetty Aparoy · 2026 · Journal of Molecular Modeling
69. cis ‐Carboxylate Enhancement of Mn(III)‐OH Hydrogen Atom Abstraction through PCET Thermodynamics
    Yuri Lee, Yujin Sim, Sehun An, Kyung‐Bin Cho, Jaeheung Cho · 2026 · Advanced Science
70. Structural expansion of benzimidazole-based FLAP inhibitors: identification of dual-action agents targeting leukotriene biosynthesis and Cancer cell proliferation
    Mehmet KARATAŞ, Hannes Engelbrecht, P M Jordan, Özge Akbulut Çalışkan, Kübra Çalışkan, Burcu Çalışkan, Oliver Werz, Erden Banoğlu · 2026 · Bioorganic & Medicinal Chemistry
71. Synthetic analogs of specialized proresolving mediators: From chemical design to therapeutic prospects in atherosclerosis
    Stanislav Kotlyarov · 2026 · Studies in natural products chemistry
72. BindingDB Entry 50018701: Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis.
    BindingDB · 2024 · UC San Diego
73. BindingDB Entry 50042670: N-1, C-3 substituted indoles as 5-LOX inhibitors--in vitro enzyme immunoaasay, mass spectral and molecular docking investigations.
    BindingDB · 2013 · UC San Diego
74. BindingDB Entry 50008977: Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.
    BindingDB · 2021 · UC San Diego
75. BindingDB Entry 50046896: Synthesis and biological evaluation of novel 5-hydroxylaminoisoxazole derivatives as lipoxygenase inhibitors and metabolism enhancing agents.
    BindingDB · 2017 · UC San Diego
76. BindingDB Entry 50018176: Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E
    BindingDB · 2024 · UC San Diego
77. BindingDB Entry 50023534: Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity.
    BindingDB · 2026 · UC San Diego
78. BindingDB Entry 50044296: Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.
    BindingDB · 2015 · UC San Diego
79. BindingDB Entry 50043834: Inhibition of 5-oxo-6,8,11,14-eicosatetraenoic acid-induced activation of neutrophils and eosinophils by novel indole OXE receptor antagonists.
    BindingDB · 2014 · UC San Diego
80. BindingDB Entry 50009000: A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1.
    BindingDB · 2021 · UC San Diego
81. BindingDB Entry 50008183: Engineered Substrate for Cyclooxygenase-2: A Pentapeptide Isoconformational to Arachidonic Acid for Managing Inflammation.
    BindingDB · 2021 · UC San Diego
82. BindingDB Entry 50047089: A potent and selective inhibitor targeting human and murine 12/15-LOX.
    BindingDB · 2017 · UC San Diego
83. BindingDB Entry 50047179: 4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP).
    BindingDB · 2017 · UC San Diego
84. BindingDB Entry 50021757: Ferroptosis and its modulators: A raising target for cancer and Alzheimer's disease.
    BindingDB · 2025 · UC San Diego
85. BindingDB Entry 50048047: Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7.
    BindingDB · 2018 · UC San Diego
86. BindingDB Entry 50048145: Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties.
    BindingDB · 2018 · UC San Diego
87. BindingDB Entry 50043819: Lead modification: amino acid appended indoles as highly effective 5-LOX inhibitors.
    BindingDB · 2014 · UC San Diego
88. BindingDB Entry 50009601: Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells.
    BindingDB · 2021 · UC San Diego
89. BindingDB Entry 50045984: Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.
    BindingDB · 2016 · UC San Diego
90. BindingDB Entry 50014874: Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents
    BindingDB · 2023 · UC San Diego
91. BindingDB Entry 50014014: Discovery of chiral N-2'-aryletheryl-1'-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium.
    BindingDB · 2022 · UC San Diego
92. BindingDB Entry 50046656: Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.
    BindingDB · 2016 · UC San Diego
93. BindingDB Entry 50001383: Photoactivation provides a mechanistic explanation for pan-assay interference behaviour of 2-aminopyrroles in lipoxygenase inhibition.
    BindingDB · 2020 · UC San Diego
94. BindingDB Entry 50020267: Structure and ligand based design for identification of highly potent molecules against 5-LOX.
    BindingDB · 2024 · UC San Diego
95. BindingDB Entry 50020555: Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.
    BindingDB · 2024 · UC San Diego
96. BindingDB Entry 50008718: Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity.
    BindingDB · 2021 · UC San Diego
97. BindingDB Entry 50011146: Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.
    BindingDB · 2021 · UC San Diego