Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease

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Items 201–300 of 897

1. Dydrogesterone exposure induces zebrafish ovulation but leads to oocytes over-ripening: An integrated histological and metabolomics study
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2. Modulation of neuroinflammation by cysteinyl leukotriene 1 and 2 receptors: implications for cerebral ischemia and neurodegenerative diseases
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3. Resolution of Pulmonary Inflammation Induced by Carbon Nanotubes and Fullerenes in Mice: Role of Macrophage Polarization
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4. Molecular insights into lipoxygenases for biocatalytic synthesis of diverse lipid mediators
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5. Arachidonic acid metabolites and endothelial dysfunction of portal hypertension
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6. Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS
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7. Nitro-fatty acid formation and metabolism
   Gregory J. Buchan, Gustavo Bonacci, Marco Fazzari, Sonia R. Salvatore, Stacy Gelhaus Wendell · 2018 · Nitric Oxide
8. An LC-MS/MS workflow to characterize 16 regio- and stereoisomeric trihydroxyoctadecenoic acids[S]
   David Fuchs, Mats Hámberg, C. Magnus Sköld, Åsa Maria Wheelock, Craig Edward Wheelock · 2018 · Journal of Lipid Research
9. Lysophospholipid acyltransferases and eicosanoid biosynthesis in zebrafish myeloid cells
   Simona Zarini, Joseph A. Hankin, Robert C. Murphy, Miguel A. Gijón · 2014 · Prostaglandins & Other Lipid Mediators
10. Immune Mechanisms in Atherosclerosis, Especially in Diabetes Type 2
    Johan Frostegård · 2013 · Frontiers in Endocrinology
11. Lipid mediators as regulators of human ILC2 function in allergic diseases
    Viktória Kónya, Jenny Mjösberg · 2016 · Immunology Letters
12. A Mononuclear Non-heme Manganese(III)–Aqua Complex as a New Active Oxidant in Hydrogen Atom Transfer Reactions
    Muniyandi Sankaralingam, Yong‐Min Lee, Deepika G. Karmalkar, Wonwoo Nam, Shunichi Fukuzumi · 2018 · Journal of the American Chemical Society
13. Recent development on liquid chromatography-mass spectrometry analysis of oxidized lipids
    Luxiao Li, Shanshan Zhong, Xia Shen, Qiujing Li, Wenxin Xu, Yongzhen Tao, Huiyong Yin · 2019 · Free Radical Biology and Medicine
14. Emerging roles for specific fatty acids in developmental processes
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15. Bacterial lipoxygenases: Biochemical characteristics, molecular structure and potential applications
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16. Phospholipids, Sphingolipids, and Cholesterol-Derived Lipid Mediators and Their Role in Neurological Disorders
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17. The Arachidonate 15-Lipoxygenase Enzyme Product 15-HETE Is Present in Heart Tissue from Patients with Ischemic Heart Disease and Enhances Clot Formation
    Annika Lundqvist, Mikael Sandstedt, Joakim Sandstedt, Ruth Wickelgren, Göran I. Hansson, Anders Jeppsson, Lillemor Mattsson Hultén · 2016 · PLoS ONE
18. Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages
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19. Interactions between α-tocopherol, polyunsaturated fatty acids, and lipoxygenases during embryogenesis
    Katie M. Lebold, Maret G. Traber · 2013 · Free Radical Biology and Medicine
20. Modulatory Effects of Mushrooms on the Inflammatory Signaling Pathways and Pro-inflammatory Mediators
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21. Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications
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22. Toxicological Effects of the Different Substances in Tobacco Smoke on Human Embryonic Development by a Systems Chemo-Biology Approach
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23. Novel liquid chromatography–mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos
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24. Molecular Mechanisms of Lipid Metabolism Disorders in Infectious Exacerbations of Chronic Obstructive Pulmonary Disease
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25. Targeting leukotriene B4in inflammation
    Antonio Di Gennaro, Jesper Z. Haeggström · 2013 · Expert Opinion on Therapeutic Targets
26. Secretion of two novel enzymes, manganese 9S-lipoxygenase and epoxy alcohol synthase, by the rice pathogen Magnaporthe salvinii
    Anneli Wennman, Ernst H. Oliw · 2012 · Journal of Lipid Research
27. 5-Lipoxygenase inhibitors: a review of recent patents (2010 – 2012)
    Bettina Hofmann, Dieter Steinhilber · 2013 · Expert Opinion on Therapeutic Patents
28. Modulation of innate immunity of patients with Alzheimer's disease by omega‐3 fatty acids
    Milan Fiala, Gijs Kooij, Karen M Wagner, Bruce D. Hammock, Matteo A. Pellegrini · 2017 · The FASEB Journal
29. Inhibition of 12/15-Lipoxygenase Protects Against β-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes
    Marimar Hernández‐Pérez, Gaurav Chopra, Jonathan A. Fine, Abass M. Conteh, Ryan M. Anderson, Amelia K. Linnemann, Chanelle Benjamin, Jennifer B. Nelson, Kara S. Benninger, Jerry L. Nadler et al. · 2017 · Diabetes
30. The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer
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31. Activatable Fluorescence and Bio/Chemiluminescence Probes for Aminopeptidases: From Design to Biomedical Applications
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32. Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis
    Devaraj K. Basavarajappa, Min Wan, Ana Lukic, Dieter Steinhilber, Bengt O. Samuelsson, Olof Rådmark · 2014 · Proceedings of the National Academy of Sciences
33. Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease
    Daniel Pettersen, Johan Broddefalk, Hans Emtenäs, Martin A. Hayes, Malin Lemurell, Marianne Swanson, Johan Ulander, Carl A. Whatling, Carl Amilon, Hans Ericsson et al. · 2019 · Journal of Medicinal Chemistry
34. Heme oxygenase-1 determines the cell fate of ferroptotic death of alveolar macrophages in COPD
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35. Arachidonic acid metabolism as a therapeutic target in AKI-to-CKD transition
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36. Ferroptosis: a new unexpected chance to treat metastatic melanoma?
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37. The antimicrobial peptide LL ‐37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils – implications for asthma
    Jitong Sun, Barbro Dahlén, B. Agerberth, Jesper Z. Haeggström · 2013 · Allergy
38. Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents
    Oliver Werz, Jana Gerstmeier, Ulrike Garscha · 2016 · Expert Opinion on Therapeutic Patents
39. Profile of Arachidonic Acid-Derived Inflammatory Markers and Its Modulation by Nitro-Oleic Acid in an Inherited Model of Amyotrophic Lateral Sclerosis
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40. Paradoxical Cellular Effects and Biological Role of the Multifaceted Compound Nordihydroguaiaretic Acid
    Jacqueline Hernández‐Damián, Ana Cristina Andérica‐Romero, José Pedraza‐Chaverrí · 2014 · Archiv der Pharmazie
41. Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics
    Jesper Z. Haeggström, Marcia E. Newcomer · 2022 · The Annual Review of Pharmacology and Toxicology
42. A Tutorial on Fatty Acid Biology
    Brian Thomas Kalish, Erica M. Fallon, Mark Puder · 2012 · Journal of Parenteral and Enteral Nutrition
43. Unraveling How Enzymes Can Use Bulky Residues To Drive Site-Selective C–H Activation: The Case of Mammalian Lipoxygenases Catalyzing Arachidonic Acid Oxidation
    Patricia Saura, Reynier Suardíaz, Laura Masgrau, José M. Lluch, Àngels González‐Lafont · 2014 · ACS Catalysis
44. Metabololipidomic profiling of functional immunoresolvent clusters and eicosanoids in mammalian tissues
    Paul C. Norris, Charles Nicholas Serhan · 2018 · Biochemical and Biophysical Research Communications
45. Leukotriene A4 hydrolase: an emerging target of natural products for cancer chemoprevention and chemotherapy
    Tam Thuy Lu Vo, Won‐Jun Jang, Chul‐Ho Jeong · 2018 · Annals of the New York Academy of Sciences
46. Sphingosine‐1‐phosphate (S1P) induces potent anti‐inflammatory effects in vitro and in vivo by S1P receptor 4‐mediated suppression of 5‐lipoxygenase activity
    Jasmin Fettel, Benjamin R. Kuhn, Nathalie Guillen, Duran Sürün, Marcus Peters, Rebekka Bauer, Carlo Angioni, Gerd Geißlinger, Frank Schnütgen, Dagmar Meyer zu Heringdorf et al. · 2018 · The FASEB Journal
47. Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain
    Karen M Wagner, Aldrin V. Gomes, Cindy B. McReynolds, Bruce D. Hammock · 2020 · Neurotherapeutics
48. Regulated cell death in cisplatin-induced AKI: relevance of myo-inositol metabolism
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49. Melatonin and ferroptosis: Mechanisms and therapeutic implications
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50. The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi
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51. Involvement of 5-Lipoxygenase in Alzheimer's Disease: A Role for DNA Methylation
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52. Expression of Fusion Proteins of Aspergillus terreus Reveals a Novel Allene Oxide Synthase
    Inga Hoffmann, Fredrik Jernerén, Ernst H. Oliw · 2013 · Journal of Biological Chemistry
53. Understanding the Mechanism of the Hydrogen Abstraction from Arachidonic Acid Catalyzed by the Human Enzyme 15-Lipoxygenase-2. A Quantum Mechanics/Molecular Mechanics Free Energy Simulation
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54. New insight into cofactor-free oxygenation from combined experimental and computational approaches
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55. Triacylglycerol‐Rich Oils of Marine Origin are Optimal Nutrients for Induction of Polyunsaturated Docosahexaenoic Acid Ester of Hydroxy Linoleic Acid (13‐DHAHLA) with Anti‐Inflammatory Properties in Mice
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56. The relationship between specialized pro-resolving lipid mediators, morbid obesity and weight loss after bariatric surgery
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57. Linoleic acid metabolism activation in macrophages promotes the clearing of intracellular Staphylococcus aureus
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58. Overview of recent drug discovery approaches for new generation leukotriene A 4 hydrolase inhibitors
    Burcu Çalışkan, Erden Banoğlu · 2012 · Expert Opinion on Drug Discovery
59. Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations
    Susanna L. Lundström, Rohit Saluja, Mikael Adner A, Jesper Z. Haeggström, Gunnar P. Nilsson, Craig Edward Wheelock · 2012 · Journal of Lipid Research
60. Ferroptosis in organ ischemia–reperfusion injuries: recent advancements and strategies
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61. Cysteinyl Leukotrienes in Allergic Inflammation
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62. 5‐Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor‐induced cell migration through T iam1 upregulation and R ac1 activation
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63. Cathelicidin LL‐37 induces time‐resolved release of LTB 4 and TXA 2 by human macrophages and triggers eicosanoid generation in vivo
    Min Wan, Oliver Soehnlein, Xiao Yan Tang, Anne M. van der Does, Erik Smedler, Per Uhlén, Lennart Lindbom, Birgitta Agerberth, Jesper Z. Haeggström · 2014 · The FASEB Journal
64. Epoxy fatty acids mediate analgesia in murine diabetic neuropathy
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65. Quantitative shotgun proteomics distinguishes wound-healing biomarker signatures in common carp skin mucus in response to Ichthyophthirius multifiliis
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66. Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity
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67. Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
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68. Potential mechanism of ferroptosis in pancreatic cancer (Review)
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69. Identification of the Substrate Access Portal of 5-Lipoxygenase
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70. Novel pharmacological approaches for treatment of obstructive sleep apnea in children
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71. Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1
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72. Fatty acids from edible sea hares: anti-inflammatory capacity in LPS-stimulated RAW 264.7 cells involves iNOS modulation
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73. Beyond leukotriene formation—The noncanonical functions of 5-lipoxygenase
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74. Clinical blood sampling for oxylipin analysis – effect of storage and pneumatic tube transport of blood on free and total oxylipin profile in human plasma and serum
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75. Cysteinyl Leukotriene Signaling Aggravates Myocardial Hypoxia in Experimental Atherosclerotic Heart Disease
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76. Modulation of T-type calcium channels by bioactive lipids
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77. Reactions of lipid hydroperoxides and how they may contribute to ferroptosis sensitivity
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78. Functional characterization of genetic enzyme variations in human lipoxygenases
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79. Expression and characterization of manganese lipoxygenase of the rice blast fungus reveals prominent sequential lipoxygenation of α-linolenic acid
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80. Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants
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81. Synthesis of 13( R )-Hydroxy-7 Z ,10 Z ,13 R ,14 E ,16 Z ,19 Z Docosapentaenoic Acid (13 R -HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins
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82. Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells
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83. Site-specific peroxidation modulates lipid bilayer mechanics
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84. Role of arachidonic acid lipoxygenase pathway in Asthma
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85. Biology and pharmacology of platelet-type 12-lipoxygenase in platelets, cancer cells, and their crosstalk
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86. Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development
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87. Chromatographic separation and biological evaluation of benzimidazole derivative enantiomers as inhibitors of leukotriene biosynthesis
    Roccaldo Sardella, Serkan Levent, Federica Ianni, Burcu Çalışkan, Jana Gerstmeier, Carlo Pergola, Oliver Werz, Erden Banoğlu, Benedetto Natalini · 2013 · Journal of Pharmaceutical and Biomedical Analysis
88. Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4+ T cells across an in vitro blood–brain barrier model
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89. Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?
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90. Cyclooxygenases and platelet functions
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91. Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens
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92. The crystal structure of Pseudomonas aeruginosa lipoxygenase Ala420Gly mutant explains the improved oxygen affinity and the altered reaction specificity
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93. Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase
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94. Non-inflammatory Physiology of “Inflammatory” Mediators – Unalamation, a New Paradigm
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95. Sex differences in eicosanoid formation and metabolism: A possible mediator of sex discrepancies in cardiovascular diseases
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96. A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood
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97. Female mice carrying a defective Alox15 gene are protected from experimental colitis via sustained maintenance of the intestinal epithelial barrier function
    Saskia Kroschwald, Cheng‐Ying Chiu, Dagmar Heydeck, Nadine Rohwer, Tatjana Gehring, Ulrike Seifert, Anke Lux, Michael Rothe, Karsten Henrich Weylandt, Hartmut Kühn · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
98. Discovery and Engineering of a Microbial Double-Oxygenating Lipoxygenase for Synthesis of Dihydroxy Fatty Acids as Specialized Proresolving Mediators
    Jin Lee, Jung-Ung An, Tae‐Hun Kim, Yoon‐Joo Ko, Jin‐Byung Park, Deok‐Kun Oh · 2020 · ACS Sustainable Chemistry & Engineering
99. Iron-dependent ferroptosis participated in benzene-induced anemia of inflammation through IRP1-DHODH-ALOX12 axis
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100. Lipid mediator profiles differ between lung compartments in asthmatic and healthy humans
     Nirina Larsson, Susanna L. Lundström, Rui Climaco Pinto, Gregory D. Rankin, Masoumeh Karimpour, Anders Blomberg, Thomas Sandström, Jamshid Pourazar, Johan Trygg, Annelie Behndig et al. · 2013 · European Respiratory Journal