Determining Fetal Manganese Exposure from Mantle Dentine of Deciduous Teeth
Open accessAbstract
Studies addressing health effects of manganese (Mn) excess or deficiency during prenatal development are hampered by a lack of biomarkers that can reconstruct fetal exposure. We propose a method using the neonatal line, a histological feature in deciduous teeth, to identify regions of mantle dentine formed at different prenatal periods. Micromeasurements of Mn in these regions may be used to reconstruct exposure at specific times in fetal development. To test our hypothesis, we recruited pregnant women before 20 weeks gestation from a cohort of farmworkers exposed to Mn-containing pesticides. We collected house floor dust samples and mother's blood during the second trimester; umbilical cord blood at birth; and shed deciduous incisors when the child was ∼7 years of age. Mn levels in mantle dentine formed during the second trimester (as (55)Mn:(43)Ca area under curve) were significantly associated with floor dust Mn loading (r(spearman) = 0.40; p = 0.0005; n = 72). Furthermore, (55)Mn:(43)Ca in sampling points immediately adjacent the neonatal line were significantly associated to Mn concentrations in cord blood (r(spearman) = 0.70; p = 0.003; n = 16). Our results support that Mn levels in mantle dentine are useful in discerning perinatal Mn exposure, offering a potentially important biomarker for the study of health effects due to environmental Mn exposure.
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The tooth-matrix biomarkers are recently developed and rigorously validated, and objectively reconstruct fetal and early postnatal exposure to multiple metals with detailed temporal resolution.
“The teeth samples we collected from the twins were analysed using recently developed and rigorously validated tooth-matrix biomarkers, which objectively reconstruct fetal and early postnatal exposure to multiple metals with detailed temporal resolution141516171819.”
From Fetal and postnatal metal dysregulation in autism (2017) · cites this paper as [16]
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- Authors
- Arora, M., Bradman, A., Austin, C., Vedar, M., Holland, N., Eskenazi, B., & Smith, D. R.
- Affiliations
- University of Technology Sydney (AU)
- University of California, Berkeley (US)
- University of California, Santa Cruz (US)
- Corresponding author
- Arora, Manish
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-04-11
- Volume
- 46
- Issue
- 9
- Pages
- 5118-5125
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- PMC
- PMC3341525
- OpenAlex
- W2001827897
- Cited by
- 99
- References
- 30
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 16 · 2019: 6 · 2018: 4 · 2017: 13 · 2016: 7 · 2015: 8 · 2014: 8 · 2013: 3 · 2012: 1
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Environmental Science & Technology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UTS ePRESS (University of Technology Sydney) (submittedVersion)
- Funders
- U.S. Environmental Protection Agency
- National Institutes of Health
- National Institute of Environmental Health Sciences (R01ES018990, K99ES019597, P01ES009605)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- primary teeth, neonatal line, manganese-55, umbilical cord blood
- MeSH terms
- Dentin, Dust, Female, Fetal Blood, Humans, Manganese, Tooth, Deciduous, Biomarkers, Maternal Exposure
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