Reactions of NO and nitrite with heme models and proteins
Abstract
Presented is an overview of the fundamental chemical properties of nitric oxide and nitrite ion in relation to the reactions with ferri- and ferroheme models and proteins potentially relevant to the roles of these species in mammalian biology.
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Recent evidence points to dinitrogen trioxide (N2O3) as a plausible intermediate for generation of NO downstream from nitrite reduction.
“Recent evidence points towards the formation of the nitrosating agent dinitrogen trioxide (N2O3) as one such plausible intermediate for the generation of NO downstream from nitrite reduction (Scheme 2) [42-45].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [45]
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- Authors
- Ford, P. C.
- Affiliations
- University of California, Santa Barbara (US)
- Corresponding author
- Ford, Peter C.
- ORCID
- Ford, Peter C.
- Venue
- Inorganic Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-07-12
- Volume
- 49
- Issue
- 14
- Pages
- 6226-6239
- ISSN
- 0020-1669 (ISSN-L)
- 1520-510X
- OpenAlex
- W2105472240
- Cited by
- 138
- References
- 144
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 2 · 2023: 9 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 15 · 2014: 11 · 2013: 17 · 2012: 11
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Inorganic Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- nitric oxide, nitrite, heme proteins, ferriheme, heme models, nitric oxide reactivity, mammal biology
- MeSH terms
- Heme, Models, Molecular, Nitric Oxide, Nitrites, Proteins, Molecular Structure
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