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Cited by 592

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Small Molecule-Capped Gold Nanoparticles as Potent Antibacterial Agents That Target Gram-Negative Bacteria

Zhao, Yuyun, Tian, Yue, Cui, Yan, Liu, Wenwen, Ma, Wanshun, Jiang, Xingyu·2010·Journal of the American Chemical Society
DOI 10.1021/ja1028843
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Abstract

This report illustrates a new strategy in designing antibacterial agents--a series of commercially available compounds, amino-substituted pyrimidines (themselves completely inactive as antibiotics), when presented on gold nanoparticles (NPs), show antibacterial activities against multidrug-resistant clinical isolates, without external sources of energy such as IR. These pyrimidine-capped gold NPs exert their antibiotic actions via sequestration of magnesium or calcium ions to disrupt the bacterial cell membrane, resulting in leakage of cytoplasmic contents including nucleic acids from compromised cell membranes, and via interaction with DNA and inhibition of protein synthesis by internalized NPs. These amino-substituted pyrimidine-capped gold NPs induce bacterial resistance more slowly compared with conventional, small-molecule antibiotics and appear harmless to human cells; these NPs may hence be useful for clinical applications.

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Crossref · 10.1021/ja1028843

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Metadata

Authors
Zhao, Y., Tian, Y., Cui, Y., Liu, W., Ma, W., & Jiang, X.
Venue
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Published
2010-08-13
Volume
132
Issue
35
Pages
12349-12356
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
DOI
10.1021/ja1028843
OpenAlex
W2083081255
Cited by
592
References
45
FWCI
6.18
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.