The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Surface-Mediated Production of Hydroxyl Radicals as a Mechanism of Iron Oxide Nanoparticle Biotoxicity
Abstract
Emerging applications of nanosized iron oxides in nanotechnology introduce vast quantities of nanomaterials into the human environment, thus raising some concerns. Here we report that the surface of γ-Fe(2)O(3) nanoparticles 20-40 nm in diameter mediates production of highly reactive hydroxyl radicals (OH(•)) under conditions of the biologically relevant superoxide-driven Fenton reaction. By conducting comparative spin-trapping EPR experiments, we show that the free radical production is attributed primarily to the catalytic reactions at the nanoparticles' surface rather than being caused by the dissolved metal ions released by the nanoparticles as previously thought. Moreover, the catalytic centers on the nanoparticle surface were found to be at least 50-fold more effective in OH(•) radical production than the dissolved Fe(3+) ions. Conventional surface modification methods such as passivating the nanoparticles' surface with up to 935 molecules of oleate or up to 18 molecules of bovine serum albumin per iron oxide core were found to be rather ineffective in suppressing production of the hydroxyl radicals. The experimental protocols developed in this study could be used as one of the approaches for developing analytical assays for assessing the free radical generating activity of a variety of nanomaterials that is potentially related to their biotoxicity.
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Cites
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Cited by
Chen, Z., Yin, J.-J., Zhou, Y.-T., Zhang, Y., Song, L., Song, M., Hu, S., & Gu, N. (2012) · ACS Nano · doi:10.1021/nn300291r · Cited by 940
A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications
Liu, Q., Zhang, A., Wang, R., Zhang, Q., & Cui, D. (2021) · Nano-Micro Letters · doi:10.1007/s40820-021-00674-8 · Cited by 745
Li, H., Shang, J., Yang, Z., Shen, W., Ai, Z., & Zhang, L. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b00040 · Cited by 538
Co3O4 Nanoparticles with Multi-Enzyme Activities and Their Application in Immunohistochemical Assay
Dong, J., Song, L., Yin, J.-J., He, W., Wu, Y., Gu, N., & Zhang, Y. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am405009f · Cited by 454
Mechanism of Heterogeneous Fenton Reaction Kinetics Enhancement under Nanoscale Spatial Confinement
Zhang, S., Sun, M., Hedtke, T., Deshmukh, A., Zhou, X., Weon, S., Elimelech, M., & Kim, J.-H. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c02192 · Cited by 422
Metadata
- Authors
- Voinov, M. A., Pagán, J. O. S., Morrison, E., Smirnova, T. I., & Smirnov, A. I.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-12-09
- Volume
- 133
- Issue
- 1
- Pages
- 35-41
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2029462611
- Cited by
- 372
- References
- 52
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Voinov, M. A., Pagán, J. O. S., Morrison, E., Smirnova, T. I., & Smirnov, A. I. (2011). Surface-Mediated Production of Hydroxyl Radicals as a Mechanism of Iron Oxide Nanoparticle Biotoxicity. Journal of the American Chemical Society. https://doi.org/10.1021/ja104683w
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