The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Mesoporous Silica-Coated Hollow Manganese Oxide Nanoparticles as Positive T1 Contrast Agents for Labeling and MRI Tracking of Adipose-Derived Mesenchymal Stem Cells
Open accessAbstract
Mesoporous silica-coated hollow manganese oxide (HMnO@mSiO(2)) nanoparticles were developed as a novel T(1) magnetic resonance imaging (MRI) contrast agent. We hypothesized that the mesoporous structure of the nanoparticle shell enables optimal access of water molecules to the magnetic core, and consequently, an effective longitudinal (R(1)) relaxation enhancement of water protons, which value was measured to be 0.99 (mM(-1)s(-1)) at 11.7 T. Adipose-derived mesenchymal stem cells (MSCs) were efficiently labeled using electroporation, with much shorter T(1) values as compared to direct incubation without electroporation, which was also evidenced by signal enhancement on T(1)-weighted MR images in vitro. Intracranial grafting of HMnO@mSiO(2)-labeled MSCs enabled serial MR monitoring of cell transplants over 14 days. These novel nanoparticles may extend the arsenal of currently available nanoparticle MR contrast agents by providing positive contrast on T(1)-weighted images at high magnetic field strengths.
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Self-citationOn the controllable soft-templating approach to mesoporous silicates
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Self-citationFlacke, S., Fischer, S., Scott, M. J., Fuhrhop, R. J., Allen, J. S., McLean, M., Winter, P., Sicard, G. A., Gaffney, P. J., Wickline, S. A., et al. (2001) · Circulation · doi:10.1161/hc3601.094303 · Cited by 515
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Cited by
Hollow‐Structured Mesoporous Materials: Chemical Synthesis, Functionalization and Applications
Li, Y., & Shi, J. (2014) · Advanced Materials · doi:10.1002/adma.201305319 · Cited by 759
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Manganese-based MRI contrast agents: past, present, and future
Pan, D., Schmieder, A. H., Wickline, S. A., & Lanza, G. M. (2011) · Tetrahedron · doi:10.1016/j.tet.2011.07.076 · Cited by 419
Multifunctional nanoparticles for brain tumor imaging and therapy
Cheng, Y., Morshed, R. A., Auffinger, B., Tobias, A. L., & Lesniak, M. S. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.006 · Cited by 349
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Metadata
- Authors
- Kim, T., Momin, E., Choi, J., Yuan, K., Zaidi, H., Kim, J., Park, M., Lee, N., McMahon, M. T., Quinones-Hinojosa, A., Bulte, J. W. M., Hyeon, T., & Gilad, A. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-02-11
- Volume
- 133
- Issue
- 9
- Pages
- 2955-2961
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2078107514
- Cited by
- 511
- References
- 8
- FWCI
- 28.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Kim, T., Momin, E., Choi, J., Yuan, K., Zaidi, H., Kim, J., Park, M., Lee, N., McMahon, M. T., Quinones-Hinojosa, A., Bulte, J. W. M., Hyeon, T., & Gilad, A. A. (2011). Mesoporous Silica-Coated Hollow Manganese Oxide Nanoparticles as Positive T1 Contrast Agents for Labeling and MRI Tracking of Adipose-Derived Mesenchymal Stem Cells. Journal of the American Chemical Society. https://doi.org/10.1021/ja1084095
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