The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Amplified Analysis of DNA by the Autonomous Assembly of Polymers Consisting of DNAzyme Wires
Abstract
A systematic study of the amplified optical detection of DNA by Mg(2+)-dependent DNAzyme subunits is described. The use of two DNAzyme subunits and the respective fluorophore/quencher-modified substrate allows the detection of the target DNA with a sensitivity corresponding to 1 × 10(-9) M. The use of two functional hairpin structures that include the DNAzyme subunits in a caged, inactive configuration leads, in the presence of the target DNA, to the opening of one of the hairpins and to the activation of an autonomous cross-opening process of the two hairpins, which affords polymer DNA wires consisting of the Mg(2+)-dependent DNAzyme subunits. This amplification paradigm leads to the analysis of the target DNA with a sensitivity corresponding to 1 × 10(-14) M. The amplification mixture composed of the two hairpins can be implemented as a versatile sensing platform for analyzing any gene in the presence of the appropriate hairpin probe. This is exemplified with the detection of the BRCA1 oncogene.
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Metadata
- Authors
- Wang, F., Elbaz, J., Orbach, R., Magen, N., & Willner, I.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-10-12
- Volume
- 133
- Issue
- 43
- Pages
- 17149-17151
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2321796562
- Cited by
- 339
- References
- 26
- FWCI
- 12.23
- Type
- journal article
- Language
- en
- Open access
- closed
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