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Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA
Abstract
Oxidation of 5-methylcytosine in DNA by ten-eleven translocation (Tet) family of enzymes has been demonstrated to play a significant role in epigenetic regulation in mammals. We found that Tet enzymes also possess the activity of catalyzing the formation of 5-hydroxymethylcytidine (5-hmrC) in RNA in vitro. In addition, the catalytic domains of all three Tet enzymes as well as full-length Tet3 could induce the formation of 5-hmrC in human cells. Moreover, 5-hmrC was present at appreciable levels (∼1 per 5000 5-methylcytidine) in RNA of mammalian cells and tissues. Our results suggest the involvement of this oxidation in RNA biology.
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“Purified TET2 protein is known to mediate oxidation of RNA m5C to hm5C18.”
From RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis (2024) · cites this paper as [18]
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“Other studies also reported RNA m5C oxidation by TET2 or Drosophila TET homologue17–20.”
From RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis (2024) · cites this paper as [18]
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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451
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Cited by
The epigenetics of aging and neurodegeneration
Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis
Zou, Z., Dou, X., Li, Y., Zhang, Z., Wang, J., Gao, B., Xiao, Y., Wang, Y., Zhao, L., Sun, C., et al. (2024) · Nature · doi:10.1038/s41586-024-07969-x · Cited by 103
Self-citationRole of RNA modifications in brain and behavior
Jung, Y., & Goldman, D. (2018) · Genes, Brain and Behavior · doi:10.1111/gbb.12444 · Cited by 66
TET dioxygenases localize at splicing speckles and promote RNA splicing
Hastert, F. D., Weber, J., Bauer, C., Zhadan, A., Singh, D. N. D., Dix, T. C., Arnold, R., Bessonov, S., Soller, M., Leonhardt, H., et al. (2025) · Nucleus · doi:10.1080/19491034.2025.2536902 · Cited by 5
“Accordingly, previous studies detected hm5C in RNA of different tissues, like the heart and spleen [37].”
Influential
Metadata
- Authors
- Fu, L., Guerrero, C. R., Zhong, N., Amato, N. J., Liu, Y., Liu, S., Cai, Q., Ji, D., Jin, S.-G., Niedernhofer, L. J., Pfeifer, G. P., Xu, G.-L., & Wang, Y.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-07-29
- Volume
- 136
- Issue
- 33
- Pages
- 11582-11585
- ISSN
- 0002-7863
- 1520-5126
- PMC
- PMC4140497
- Cited by
- 404
- References
- 6
- Language
- en
- Funders
- National Institutes of Health (P01 AG043376, R01 CA101864)
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