The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Optical Control of CRISPR/Cas9 Gene Editing
Open accessAbstract
The CRISPR/Cas9 system has emerged as an important tool in biomedical research for a wide range of applications, with significant potential for genome engineering and gene therapy. In order to achieve conditional control of the CRISPR/Cas9 system, a genetically encoded light-activated Cas9 was engineered through the site-specific installation of a caged lysine amino acid. Several potential lysine residues were identified as viable caging sites that can be modified to optically control Cas9 function, as demonstrated through optical activation and deactivation of both exogenous and endogenous gene function.
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Cites
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
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Cited by
The CRISPR tool kit for genome editing and beyond
Adli, M. (2018) · Nature Communications · doi:10.1038/s41467-018-04252-2 · Cited by 1,545
Xiong, Y., Zhang, J., Yang, Z., Mou, Q., Ma, Y., Xiong, Y., & Lu, Y. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b09211 · Cited by 689
Alsaiari, S. K., Patil, S., Alyami, M., Alamoudi, K. O., Aleisa, F. A., Merzaban, J. S., Li, M., & Khashab, N. M. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11754 · Cited by 517
Carlson-Stevermer, J., Abdeen, A. A., Kohlenberg, L., Goedland, M., Molugu, K., Lou, M., & Saha, K. (2017) · Nature Communications · doi:10.1038/s41467-017-01875-9 · Cited by 170
Recent Progress in CRISPR/Cas9 Technology
Mei, Y., Wang, Y., Chen, H., Sun, Z. S., & Ju, X.-D. (2016) · Journal of Genetics and Genomics · doi:10.1016/j.jgg.2016.01.001 · Cited by 148
Metadata
- Authors
- Hemphill, J., Borchardt, E. K., Brown, K., Asokan, A., & Deiters, A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-04-23
- Volume
- 137
- Issue
- 17
- Pages
- 5642-5645
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2092493681
- Cited by
- 269
- References
- 12
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Hemphill, J., Borchardt, E. K., Brown, K., Asokan, A., & Deiters, A. (2015). Optical Control of CRISPR/Cas9 Gene Editing. Journal of the American Chemical Society. https://doi.org/10.1021/ja512664v
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