The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Remotely Triggered Liposome Release by Near-Infrared Light Absorption via Hollow Gold Nanoshells
Open accessAbstract
An elusive goal for systemic drug delivery is to provide both spatial and temporal control of drug release. Liposomes have been evaluated as drug delivery vehicles for decades, but their clinical significance has been limited by slow release or poor availability of the encapsulated drug. Here we show that near-complete liposome release can be initiated within seconds by irradiating hollow gold nanoshells (HGNs) with a near-infrared (NIR) pulsed laser. Our findings reveal that different coupling methods such as having the HGNs tethered to, encapsulated within, or suspended freely outside the liposomes, all triggered liposome release but with different levels of efficiency. For the underlying content release mechanism, our experiments suggest that the microbubble formation and collapse due to the rapid temperature increase of the HGN is responsible for liposome disruption, as evidenced by the formation of solid gold particles after the NIR irradiation and the coincidence of a laser power threshold for both triggered release and pressure fluctuations in the solution associated with cavitation. These effects are similar to those induced by ultrasound and our approach is conceptually analogous to the use of optically triggered nano-"sonicators" deep inside the body for drug delivery. We expect HGNs can be coupled with any nanocarriers to promote spatially and temporally controlled drug release. In addition, the capability of external HGNs to permeabilize lipid membranes can facilitate the cellular uptake of macromolecules including proteins and DNA and allow for promising applications in gene therapy.
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Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
Synthetic Micelle Sensitive to IR Light via a Two-Photon Process
Goodwin, A. P., Mynar, J. L., Ma, Y., Fleming, G. R., & Fréchet, J. M. J. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0523035 · Cited by 352
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Schroeder, A., Heller, D. A., Winslow, M. M., Dahlman, J. E., Pratt, G. W., Langer, R., Jacks, T., & Anderson, D. G. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3180 · Cited by 1,159
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Al-Jamal, W. T., & Kostarelos, K. (2011) · Accounts of Chemical Research · doi:10.1021/ar200105p · Cited by 696
Kim, H., Lee, D., Kim, J., Kim, T.-I., & Kim, W. J. (2013) · ACS Nano · doi:10.1021/nn403096s · Cited by 420
Inorganic nanoparticles: A potential cancer therapy for human welfare
Pugazhendhi, A., Edison, T. N. J. I., Karuppusamy, I., & Kathirvel, B. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.01.034 · Cited by 325
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Kumar, S., Allard, J.-F., Morris, D., Dory, Y. L., Lepage, M., & Zhao, Y. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm16380b · Cited by 146
Liposomal gene delivery mediated by tissue-engineered scaffolds
Kulkarni, M., Greiser, U., O’Brien, T., & Pandit, A. (2010) · Trends in Biotechnology · doi:10.1016/j.tibtech.2009.10.003 · Cited by 81
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Metadata
- Authors
- Wu, G., Mikhailovsky, A., Khant, H. A., Fu, C., Chiu, W., & Zasadzinski, J. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-06-11
- Volume
- 130
- Issue
- 26
- Pages
- 8175-8177
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2001942810
- Cited by
- 500
- References
- 4
- FWCI
- 15.07
- Type
- journal article
- Language
- en
- Open access
- green
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