Cited by 146Nanoparticle-Based Drug DeliveryAdvanced Polymer Synthesis and CharacterizationNanoplatforms for cancer theranostics

Near-infrared light sensitive polypeptide block copolymer micelles for drug delivery

Kumar, Surjith, Allard, Jean-Francois, Morris, Denis, Dory, Yves L., Lepage, Martin, Zhao, Yue·2012·Journal of Materials Chemistry

Abstract

A new biocompatible block copolymer (BCP) composed of poly(ethylene oxide) (PEO) and poly(L-glutamic acid) bearing a number of 6-bromo-7-hydroxycoumarin-4-ylmethyl groups, PEO114-b-P(LGA0.62-co-COU0.38)34, was prepared for near-infrared (NIR) light-induced drug delivery. We demonstrate that micelles of PEO114-b-P(LGA0.62-co-COU0.38)34 could be disrupted by 794 nm NIR light excitation via two-photon absorption. This was linked to the high two-photon absorption cross-section of the coumarin moiety. Disruption followed from the NIR light-induced removal of coumarin groups from the polypeptide block that shifted the hydrophilic–hydrophobic balance toward the destabilization of the micelles in aqueous solution. Using NIR light-triggered disruption of BCP micelles, we investigated the release of an antibacterial drug (Rifampicin) and an anticancer drug (Paclitaxel) loaded into the photosensitive BCP micelles. We found that the two drugs could be released effectively upon NIR light exposure of the micellar solution. To our knowledge, this is the first study of NIR light-triggered disruption of biocompatible polypeptide BCP micelles and its use for drug release. This is a step forward towards light-controllable drug delivery applications.

Integrity signals

Registry

Crossref · 10.1039/c2jm16380b

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kumar, S., Allard, J.-F., Morris, D., Dory, Y. L., Lepage, M., & Zhao, Y.
Affiliations
Université de Sherbrooke (CA)
Corresponding author
  • Dory, Yves L.
  • Lepage, Martin
  • Zhao, Yue
Venue
Journal of Materials Chemistry
Published
2012
Volume
22
Issue
15
Pages
7252
ISSN
  • 0959-9428 (ISSN-L)
  • 1364-5501
OpenAlex
W2095976477
Cited by
146
References
56
Citations by year
2026: 3 · 2025: 9 · 2024: 8 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 16 · 2017: 11 · 2016: 15 · 2015: 13 · 2014: 16 · 2013: 14 · 2012: 4
FWCI
6.10
Type
journal article
Language
en
Open access
closed
Locations
Journal of Materials Chemistry (publishedVersion)
Funders
  • Canada Research Chairs
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
near-infrared light-triggered drug release, two-photon absorption, poly(ethylene oxide), poly(L-glutamic acid), hydrophilic-hydrophobic balance, rifampicin, paclitaxel, antibacterial drug delivery, anticancer drug delivery

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review