The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Using Cocrystals To Systematically Modulate Aqueous Solubility and Melting Behavior of an Anticancer Drug
Open accessAbstract
Five cocrystals of an anticancer compound have been assembled using a well-defined hydrogen-bond-based supramolecular approach that produced the necessary structural consistency in the resulting solids. These cocrystals contain aliphatic even-numbered dicarboxylic acids of increasing chain length, and as a result, the physical properties of the cocrystals can be related to the molecular structure of the acid. The melting points of the five cocrystals show an excellent correlation with the melting points of the individual acids, and it has also been shown that aqueous solubility can be increased by a factor of 2.5 relative to that of the individual drug. Consequently, cocrystals can offer a range of solid forms from which can be chosen an active ingredient where a particular physical property can be dialed in, provided that the cocrystals show considerable structural consistency and that systematic changes are made to the participating cocrystallizing agents.
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Cites
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Self-citationLipid-based vehicles for the oral delivery of poorly water soluble drugs
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Single-Crystal-to-Single-Crystal Topochemical Polymerizations by Design
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Cited by
Pharmaceutical cocrystals: An overview
Qiao, N., Li, M., Schlindwein, W., Malek, N., Davies, A., & Trappitt, G. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.07.037 · Cited by 665
Pharmaceutical cocrystals and poorly soluble drugs
Thakuria, R., Delori, A., Jones, W., Lipert, M. P., Roy, L., & Rodríguez-Hornedo, N. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.10.043 · Cited by 614
Suresh, K., & Matzger, A. J. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201907652 · Cited by 369
Pharmaceutical cocrystals: from serendipity to design to application
Kavanagh, O. N., Croker, D. M., Walker, G. M., & Zaworotko, M. J. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2018.11.023 · Cited by 323
Metadata
- Authors
- Aakeröy, C. B., Forbes, S., & Desper, J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-11-06
- Volume
- 131
- Issue
- 47
- Pages
- 17048-17049
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2014855732
- Cited by
- 297
- References
- 14
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- green
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