The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Near-Infrared Fluorescent Macromolecular Reporters for Real-Time Imaging and Urinalysis of Cancer Immunotherapy
Abstract
Real-time imaging of immunoactivation is imperative for cancer immunotherapy and drug discovery; however, most existing imaging agents possess “always-on” signals and thus have poor signal correlation with immune responses. Herein, renal-clearable near-infrared (NIR) fluorescent macromolecular reporters are synthesized to specifically detect an immunoactivation-related biomarker (granzyme B) for real-time evaluation of cancer immunotherapy. Composed of a peptide-caged NIR signaling moiety linked with a hydrophilic poly(ethylene glycol) (PEG) passivation chain, the reporters not only specifically activate their fluorescence by granzyme B but also passively target the tumor of living mice after systemic administration. Such granzyme B induced in vivo signals of the reporters are validated to correlate well with the populations of cytotoxic T lymphocytes (CD8 + ) and T helper (CD4 + ) cells detected in tumor tissues. By virtue of their ideal renal clearance efficiency (60% injected doses at 24 h postinjection), the reporters can be used for optical urinalysis of immunoactivation simply by detecting the status of excreted reporters. This study thus proposes a molecular optical imaging approach for noninvasive evaluation of cancer immunotherapeutic efficacy in living animals.
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A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
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Fluorescent Probes for Disease Diagnosis
Wang, X., Ding, Q., Groleau, R. R., Wu, L., Mao, Y., Che, F., Kotova, O., Scanlan, E. M., Lewis, S. E., Li, P., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00776 · Cited by 543
Activity‐Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image‐Guided Surgery
Li, H., Kim, D., Yao, Q., Ge, H., Chung, J., Fan, J., Wang, J., Peng, X., & Yoon, J. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202009796 · Cited by 363
Hemicyanine‐Based Near‐Infrared Activatable Probes for Imaging and Diagnosis of Diseases
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Self-citationYan, D., Wang, M., Wu, Q., Niu, N., Li, M., Song, R., Rao, J., Kang, M., Zhang, Z., Zhou, F., et al. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202202614 · Cited by 187
Xiao, P., Liang, M., Yang, S., Sun, Y., Li, J., Gu, Z., Zhang, L., Fan, Q., Jiang, X., & Wu, W. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.121993 · Cited by 36
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Metadata
- Authors
- He, S., Li, J., Lyu, Y., Huang, J., & Pu, K.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-03-20
- Volume
- 142
- Issue
- 15
- Pages
- 7075-7082
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W3012484408
- Cited by
- 282
- References
- 43
- FWCI
- 14.82
- Type
- journal article
- Language
- en
- Open access
- closed
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