Cited by 188Nanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies

Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen

Yan, Dingyuan, Wang, Miao, Wu, Qian, Niu, Niu, Li, Meng, Song, Ruixiang, Rao, Jie, Kang, Miaomiao +4 more·2022·Angewandte Chemie International Edition

Abstract

Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed and prepared based on benzo[c]thiophene unit as a building block; it can be used for simultaneous fluorescence imaging (FLI) in the second near‐infrared (NIR‐II) window, photoacoustic imaging (PAI), photothermal imaging (PTI), and thermal eradication of tumors. Further experiments validate that photothermal therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys the primary tumor but also enhances immunogenicity for further suppressing the growth of tumors at distant sites. Furthermore, PTT combining a programmed death‐ligand 1 (PD‐L1) antibody prevents the metastasis and recurrence of cancer by potentiating the effect of immunotherapy.

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Crossref · 10.1002/anie.202202614

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Authors
Yan, D., Wang, M., Wu, Q., Niu, N., Li, M., Song, R., Rao, J., Kang, M., Zhang, Z., Zhou, F., Wang, D., & Tang, B. Z.
Affiliations
  • Shenzhen University (CN)
  • Hainan University (CN)
  • Chinese University of Hong Kong (HK)
Corresponding author
  • Zhou, Feifan
  • Wang, Dong
  • Tang, Ben Zhong
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2022-05-05
Volume
61
Issue
27
Pages
e202202614-e202202614
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W4221090070
Cited by
187
References
50
Citations by year
2026: 20 · 2025: 36 · 2024: 64 · 2023: 48 · 2022: 19
FWCI
12.13
Type
journal article
Language
en
Open access
closed
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Postdoctoral Research Foundation of China (2019M663030)
  • National Natural Science Foundation of China (52122317, 22175120, 21788102, 82171990)
  • Natural Science Foundation of Guangdong Province for Distinguished Young Scholars (2020B1515020011)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
Keywords
photothermal immunotherapy, aggregation-induced emission, theranostic nanoparticles, benzo[c]thiophene, fluorescence imaging, photoacoustic imaging, photothermal imaging, abscopal effect, PD-L1 inhibitors, metastasis, tumor recurrence, multimodal imaging
MeSH terms
Theranostic Nanomedicine, Humans, Immunotherapy, Neoplasms, Phototherapy, Cell Line, Tumor, Nanoparticles, Photoacoustic Techniques, Multimodal Imaging

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