The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
A Chlorin-Based Nanoscale Metal–Organic Framework for Photodynamic Therapy of Colon Cancers
Open accessAbstract
We report here the rational design of the first chlorin-based nanoscale metal-organic framework (NMOF), DBC-UiO, with much improved photophysical properties over the previously reported porphyrin-based NMOF, DBP-UiO. Reduction of the DBP ligands in DBP-UiO to the DBC ligands in DBC-UiO led to a 13 nm red shift and an 11-fold increase in the extinction coefficient of the lowest-energy Q band. While inheriting the crystallinity, stability, porosity, and nanoplate morphology of DBP-UiO, DBC-UiO sensitizes more efficient (1)O2 generation and exhibits significantly enhanced photodynamic therapy (PDT) efficacy on two colon cancer mouse models as a result of its improved photophysical properties. Both apoptosis and immunogenic cell death contributed to killing of cancer cells in DBC-UiO-induced PDT.
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Zhang, Y., Wang, F., Liu, C., Wang, Z., Kang, L., Huang, Y., Dong, K., Ren, J., & Qu, X. (2018) · ACS Nano · doi:10.1021/acsnano.7b07746 · Cited by 854
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Abánades Lázaro, I., & Forgan, R. S. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.09.009 · Cited by 678
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Li, R., Chen, T., & Pan, X. (2021) · ACS Nano · doi:10.1021/acsnano.0c09617 · Cited by 555
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Metadata
- Authors
- Lu, K., He, C., & Lin, W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-06-12
- Volume
- 137
- Issue
- 24
- Pages
- 7600-7603
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W596767445
- Cited by
- 469
- References
- 32
- FWCI
- 36.87
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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