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Cited by 334

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

An LC-MS Method for Analyzing Total Resveratrol in Grape Juice, Cranberry Juice, and in Wine

Wang, Yan, Catana, Florentina, Yang, Yanan, Roderick, Robin, van Breemen, Richard B.·2002·Journal of Agricultural and Food Chemistry
DOI 10.1021/jf010812u
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Abstract

Resveratrol is an antioxidant found in grapes, grape products, and some other botanical sources with antiinflammatory and anticancer properties. In grapes and wine, it occurs both as free resveratrol and piceid, the 3beta-glucoside of resveratrol. Here we report a liquid chromatography-mass spectrometry method to analyze total resveratrol (including free resveratrol and resveratrol from piceid) in fruit products and wine. Samples were extracted using methanol, enzymatically hydrolyzed, and analyzed using reversed phase HPLC with positive ion atmospheric pressure chemical ionization (APCI) mass spectrometric detection. Following APCI, the abundance of protonated molecules was recorded using selected ion monitoring (SIM) of m/z 229. An external standard curve was used for quantitation, which showed a linear range of 0.52-2260 pmol of trans-resveratrol injected on-column with a correlation coefficient 0.9999. The coefficient of variance of the response factor over the same concentration range was determined to be 5.8%, and the intra-assay coefficient of variance was determined to be 4.2% (n = 7). The limit of quantitation, defined as signal-to-noise 10:1, was determined to be 0.31 pmol injected on-column. The extraction efficiency of the method was determined to be 92%. The stability of resveratrol under different conditions was also examined. For example, resveratrol was stable for up to 5 days at 4 degrees C in the dark but was not stable at room temperature without protection from light. Resveratrol was detected in grape, cranberry, and wine samples. Concentrations ranged from 1.56 to 1042 nmol/g in Concord grape products, and from 8.63 to 24.84 micromol/L in Italian red wine. The concentrations of resveratrol were silmilar in cranberry and grape juice at 1.07 and 1.56 nmol/g, respectively.

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Metadata

Authors
Wang, Y., Catana, F., Yang, Y., Roderick, R., & van Breemen, R. B.
Venue
Journal of Agricultural and Food Chemistry
Publisher
American Chemical Society (ACS)
Published
2002-01-01
Volume
50
Issue
3
Pages
431-435
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
DOI
10.1021/jf010812u
OpenAlex
W2072342869
Cited by
334
References
19
FWCI
6.69
Type
journal article
Language
en
Open access
closed

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