Low-calorie cranberry juice supplementation reduces plasma oxidized LDL and cell adhesion molecule concentrations in men
Open accessAbstract
Elevated circulating concentrations of oxidized LDL (OxLDL) and cell adhesion molecules are considered to be relevant markers of oxidative stress and endothelial activation which are implicated in the development of CVD. On the other hand, it has been suggested that dietary flavonoid consumption may be cardioprotective through possible favourable impacts on LDL particle oxidation and endothelial activation. The present study was undertaken to determine the effect of the daily consumption of low-calorie cranberry juice cocktail on plasma OxLDL, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin concentrations in men. Thirty men (mean age 51 (sd 10) years) were recruited and asked to consume increasing daily doses of cranberry juice cocktail (125, 250 and 500 ml/d) over three successive periods of 4 weeks. Plasma OxLDL and adhesion molecule concentrations were measured by ELISA before and after each phase. We noted a significant decrease in plasma OxLDL concentrations following the intervention (P < 0.0001). We also found that plasma ICAM-1 (P < 0.0001) and VCAM-1 (P < 0.05) concentrations decreased significantly during the course of the study. In summary, the present results show that daily cranberry juice cocktail consumption is associated with decreases in plasma OxLDL, ICAM-1 and VCAM-1 concentrations in men.
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Of 20 trials conducted using different varieties of fresh and processed berry products, only two showed a significant decrease in systolic blood pressure: one in healthy men following cranberry juice supplementation and the other in subjects with CVD risk factors following mixed berry supplementation.
“Of 20 trials conducted using different varieties of fresh and processed berry products, only two showed a significant decrease in systolic blood pressure: one was conducted in healthy men following cranberry juice supplementation46 and the other was in subjects with CVD risk factors following mixed berry supplementation.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [46]
None of the clinical studies showed any significant effect of berry intervention on biomarkers of inflammation, with the exception of a significant decrease in adhesion molecules following cranberry juice supplementation in healthy volunteers.
“Interestingly, none of these clinical studies showed any significant effect of berry intervention on biomarkers of inflammation, with the exception of a significant decrease in adhesion molecules following cranberry juice supplementation in healthy volunteers.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [46]
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Berries: emerging impact on cardiovascular health
Basu, A., Rhone, M., & Lyons, T. J. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00273.x · Cited by 462 · see citing works
“…UK); 750 mL/day (3 × 250 mL) No effects on blood or cellular antioxidant status, lipid status, or oxidative DNA damage in cranberry group versus placebo (P > 0.05) Ruel et al. (2008)46 Sixteen weeks Successive 4-week phases of increasing dose of cranberry juice Thirty healthy men (mean age, 51 ±…”
InfluentialEffect of cranberry extracts on lipid profiles in subjects with type 2 diabetes
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Strawberries, Blueberries, and Cranberries in the Metabolic Syndrome: Clinical Perspectives
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- Authors
- Ruel, G., Pomerleau, S., Couture, P., Lemieux, S., Lamarche, B., & Couillard, C.
- Affiliations
- Université Laval (CA)
- Centre hospitalier universitaire de Québec (CA)
- Corresponding author
- Couillard, Charles
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008-02
- Volume
- 99
- Issue
- 2
- Pages
- 352-359
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2029249017
- Cited by
- 96
- References
- 56
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 11 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 6 · 2014: 8 · 2013: 7 · 2012: 3
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- cranberry juice, oxidized LDL, adhesion molecules, ICAM-1, VCAM-1, E-selectin, flavonoids, oxidative stress, endothelial activation, cardiovascular risk, men
- MeSH terms
- Anthropometry, Beverages, Blood Pressure, Heart Rate, Humans, Lipids, Lipoproteins, LDL, Male, Middle Aged, Cell Adhesion Molecules, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, E-Selectin, Vaccinium macrocarpon
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