The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Pharmacometrics of Stilbenes: Seguing Towards the Clinic
Abstract
Stilbenes are small molecular weight (approximately 200-300 g/mol), naturally occurring compounds and are found in a wide range of plant sources, aromatherapy products, and dietary supplements. These molecules are synthesized via the phenylpropanoid pathway and share some structural similarities to estrogen. Upon environmental threat, the plant host activates the phenylpropanoid pathway and stilbene structures are produced and subsequently secreted. Stilbenes act as natural protective agents to defend the plant against viral and microbial attack, excessive ultraviolet exposure, and disease. One stilbene, resveratrol, has been extensively studied and has been shown to possess potent anti-cancer, antiinflammatory and anti-oxidant activities. Found primarily in the skins of grapes, resveratrol is synthesized by Vitis vinifera grapevines in response to fungal infection or other environmental stressors. Considerable research showing resveratrol to be an attractive candidate in combating a wide variety of cancers and diseases has fueled interest in determining the disease-fighting capabilities of other structurally similar stilbene compounds. The purpose of this review is to describe four such structurally similar stilbene compounds, piceatannol, pinosylvin, rhapontigenin, and pterostilbene and detail some current pharmaceutical research and highlight their potential clinical applications.
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Cites
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Cited by
Metabolism and roles of stilbenes in plants
Chong, J., Poutaraud, A., & Hugueney, P. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.05.012 · Cited by 664
Growth inhibitory effect of grape phenolics against wine spoilage yeasts and acetic acid bacteria
Pastorkova, E., Zakova, T., Landa, P., Novakova, J., Vadlejch, J., & Kokoska, L. (2013) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2012.12.018 · Cited by 64
Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes in Cannabis sativa
O’Croinin, C., Garcia Guerra, A., Doschak, M. R., Löbenberg, R., & Davies, N. M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071941 · Cited by 25
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Metadata
- Authors
- Roupe, K., Remsberg, C., Yanez, J., & Davies, N.
- Venue
- Current Clinical Pharmacology
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2006-01-01
- Volume
- 1
- Issue
- 1
- Pages
- 81-101
- ISSN
- 1574-8847 (ISSN-L)
- OpenAlex
- W2123133124
- Cited by
- 309
- References
- 101
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- closed
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