The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Bioactive Peptides in Amaranth (Amaranthus hypochondriacus) Seed
Abstract
Amaranth seeds are rich in protein with a high nutritional value, but little is known about their bioactive compounds that could benefit health. The objectives of this research were to investigate the presence, characterization, and the anticarcinogenic properties of the peptide lunasin in amaranth seeds. Furthermore, to predict and identify other peptides in amaranth seed with potential biological activities. ELISA showed an average concentration of 11.1 microg lunasin equivalent/g total extracted protein in four genotypes of mature amaranth seeds. Glutelin fraction had the highest lunasin concentration (3.0 microg/g). Lunasin was also identified in albumin, prolamin and globulin amaranth protein fractions and even in popped amaranth seeds. Western blot analysis revealed a band at 18.5 kDa, and MALDI-TOF analysis showed that this peptide matched more than 60% of the soybean lunasin peptide sequence. Glutelin extracts digested with trypsin, showed the induction of apoptosis against HeLa cells. Prediction of other bioactive peptides in amaranth globulins and glutelins were mainly antihypertensive. This is the first study that reports the presence of a lunasin-like peptide and other potentially bioactive peptides in amaranth protein fractions.
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Citations
Cites
Food-derived peptides with biological activity: from research to food applications.
Hartmann, R., & Meisel, H. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.01.013 · Cited by 1,102
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A soybean cDNA encoding a chromatin-binding peptide inhibits mitosis of mammalian cells.
Galvez, A. F., & de Lumen, B. O. (1999) · Nature Biotechnology · doi:10.1038/8676 · Cited by 174
Cited by
Sánchez, A., & Vázquez, A. (2017) · Food Quality and Safety · doi:10.1093/fqs/fyx006 · Cited by 868
Bioactive peptides in cereals and legumes: agronomical, biochemical and clinical aspects.
Malaguti, M., Dinelli, G., Leoncini, E., Bregola, V., Bosi, S., Cicero, A., & Hrelia, S. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151121120 · Cited by 180
Huang, W.-Y., Davidge, S. T., & Wu, J. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.550071 · Cited by 157
Preventive and therapeutic potential of peptides from cereals against cancer
Ortiz-Martinez, M., Winkler, R., & García-Lara, S. (2014) · Journal of Proteomics · doi:10.1016/j.jprot.2014.03.044 · Cited by 100
López, D. N., Galante, M., Raimundo, G., Spelzini, D., & Boeris, V. (2019) · Food Research International · doi:10.1016/j.foodres.2018.08.056 · Cited by 77
Metadata
- Authors
- Silva-Sánchez, C., de la Rosa, A. P. B., León-Galván, M. F., de Lumen, B. O., de León-Rodríguez, A., & de Mejía, E. G.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-01-23
- Volume
- 56
- Issue
- 4
- Pages
- 1233-1240
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1991071453
- Cited by
- 278
- References
- 3
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Silva-Sánchez, C., de la Rosa, A. P. B., León-Galván, M. F., de Lumen, B. O., de León-Rodríguez, A., & de Mejía, E. G. (2008). Bioactive Peptides in Amaranth (Amaranthus hypochondriacus) Seed. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf072911z
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