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Antioxidant and DNA-Protective Activities of Chlorogenic Acid Isomers
Abstract
Chlorogenic acid is a well-known antioxidant and has more isomers according to the difference in binding location and number of caffeic on quinic acid. In this study, we investigated and compared the profiles of antioxidant and DNA-protective activities of chlorogenic acid isomers including three caffeoylquinic acid isomers (3-O-caffeoylquinic acid, 3-CQA; 4-O-caffeoylquinic acid, 4-CQA; and 5-O- caffeoylquinic acid, 5-CQA) and three dicaffeoylquinic acid isomers (3,5-dicaffeoyl-quinic acid, ICAA; 3,4-dicaffeoylquinic acid, ICAB; and 4,5-dicaffeoyl-quinic acid, ICAC). The results showed that each of chlorogenic acid isomers studied exhibited antioxidant activities and DNA damage protective effects to various extents. On the whole, dicaffeoylquinic acids possessed better antioxidant activities, mostly because they have more hydroxyl groups than caffeoylquinic acids. Three caffeoylquinic acid isomers showed quite similar antioxidant activities, indicating that the position of esterification on the quinic moiety of caffeoylquinic acid had no effect on its antioxidant activities. Quite the contrary, a difference among dicaffeoylquinic acid isomers was observed, namely, ICAA and ICAB exhibited the same antioxidant activities, whereas ICAC had higher antioxidant activities than ICAA and ICAB in some assays, which implied that their antioxidant activities were probably influenced by the position of esterification on the quinic moiety. We speculated that this difference might be due to the fact that there may exist a steric hindrance effect in the ICAC. However, this assumption needs to be further confirmed.
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Cites
Antioxidant activity applying an improved ABTS radical cation decolorization assay
Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., & Rice-Evans, C. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,165
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085
Prior, R. L., Wu, X., & Schaich, K. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0502698 · Cited by 5,650
Determination of Antioxidant and Antimicrobial Activities of Rumex crispus L. Extracts
Yıldırım, A., Mavi, A., & Kara, A. A. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0103572 · Cited by 1,165
Clifford, M. N. (2000) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(20000515)80:7<1033::aid-jsfa595>3.0.co;2-t · Cited by 966
In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid
Sato, Y., Itagaki, S., Kurokawa, T., Ogura, J., Kobayashi, M., Hirano, T., Sugawara, M., & Iseki, K. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.09.035 · Cited by 965
Antioxidant assays for plant and food components
Moon, J.-K., & Shibamoto, T. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf803537k · Cited by 958
Free radical-induced damage to DNA: mechanisms and measurement
Dizdaroglu, M., Jaruga, P., Birincioglu, M., & Rodriguez, H. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00826-2 · Cited by 953
Discriminating between the Six Isomers of Dicaffeoylquinic Acid by LC-MSn
Clifford, M. N., Knight, S., & Kuhnert, N. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050046h · Cited by 691
Singh, B. N., Singh, B. R., Singh, R. L., Prakash, D., Dhakarey, R., Upadhyay, G., & Singh, H. B. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.01.034 · Cited by 425
Wang, G.-F., Shi, L.-P., Ren, Y.-D., Liu, Q.-F., Liu, H.-F., Zhang, R.-J., Li, Z., Zhu, F.-H., He, P.-L., Tang, W., et al. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2009.05.002 · Cited by 403
Nakatani, N., Kayano, S.-I., Kikuzaki, H., Sumino, K., Katagiri, K., & Mitani, T. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000422s · Cited by 397
Evidence for health benefits of plant phenols: local or systemic effects?
Hollman, P. C. H. (2001) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.900 · Cited by 378
Relationships between Free Radical Scavenging and Antioxidant Activity in Foods
Alamed, J., Chaiyasit, W., McClements, D. J., & Decker, E. A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf803436c · Cited by 306
Inhibitory effects of chlorogenic acids on linoleic acid peroxidation and haemolysis
Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., & Kido, R. (1994) · Phytochemistry · doi:10.1016/s0031-9422(00)89778-2 · Cited by 288
Profiling the Chlorogenic Acids and Other Caffeic Acid Derivatives of Herbal Chrysanthemum by LC−MSn
Clifford, M. N., Wu, W., Kirkpatrick, J., & Kuhnert, N. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062314x · Cited by 238
Jin, U.-H., Lee, J.-Y., Kang, S.-K., Kim, J.-K., Park, W.-H., Kim, J.-G., Moon, S.-K., & Kim, C.-H. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.02.028 · Cited by 221
Contribution of Individual Polyphenolics to Total Antioxidant Capacity of Plums
Chun, O. K., Kim, D.-O., Moon, H. Y., Kang, H. G., & Lee, C. Y. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0343579 · Cited by 215
Kasai, H., Fukada, S., Yamaizumi, Z., Sugie, S., & Mori, H. (2000) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(00)00014-4 · Cited by 212
Xiang, Z.-N., & Ning, Z. (2007) · LWT · doi:10.1016/j.lwt.2007.08.006 · Cited by 151
Oxidative stress during the chronic phase after stroke
Alexandrova, M. L., & Bochev, P. G. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.017 · Cited by 135
Zheng, L., Dai, F., Zhou, B., Li, Y., & Liu, Z. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.07.010 · Cited by 134
Evaluation of antioxidant ability of ethanolic extract from dill (Anethum graveolens L.) flower
Shyu, Y., Lin, J.-T., Chang, Y.-T., Chiang, C.-J., & Yang, D. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.12.039 · Cited by 114
Mullen, W., Nemzer, B. V., Ou, B., Stalmach, A., Hunter, J., Clifford, M. N., & Combet, E. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200122m · Cited by 114
Natural Antioxidant, Chlorogenic Acid, Protects Against DNA Breakage Caused by Monochloramine
SHIBATA, H., SAKAMOTO, Y., OKA, M., & KONO, Y. (1999) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.63.1295 · Cited by 91
Peroxyl Radical Scavenging Activity of Caffeic Acid and Its Related Phenolic Compounds in Solution
Terao, J., Karasawa, H., Arai, H., et al. (1993) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.57.1204 · Cited by 68
Radical-scavenging and antioxidant activity of avenanthramides
Fagerlund, A., Sunnerheim, K., & Dimberg, L. H. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.07.101 · Cited by 67
Jeong, J. B., Park, J. H., Lee, H. K., Ju, S. Y., Hong, S. C., Lee, J. R., Chung, G. Y., Lim, J. H., & Jeong, H. J. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.11.039 · Cited by 65
Gordon, M. H., & Wishart, K. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf100106e · Cited by 48
Tang, Y., & Liu, Z. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf802462h · Cited by 46
Napolitano, A., & d’Ischia, M. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo015965v · Cited by 33
Cited by
Vignoli, J. A., Viegas, M. C., Bassoli, D. G., & Benassi, M. D. T. (2014) · Food Research International · doi:10.1016/j.foodres.2013.06.006 · Cited by 261
Rudrapal, M., Rakshit, G., Singh, R. P., Garse, S., Khan, J., & Chakraborty, S. (2024) · Antioxidants · doi:10.3390/antiox13040429 · Cited by 259
Mehmood, A., Ishaq, M., Zhao, L., Yaqoob, S., Safdar, B., Nadeem, M., Munir, M., & Wang, C. (2019) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2018.10.013 · Cited by 184
Chlorogenic Acid and Mental Diseases: From Chemistry to Medicine
Nabavi, S. F., Tejada, S., Setzer, W. N., Gortzi, O., Sureda, A., Braidy, N., Daglia, M., Manayi, A., & Nabavi, S. M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160325120625 · Cited by 152
Bułdak, R. J., Hejmo, T., Osowski, M., Bułdak, Ł., Kukla, M., Polaniak, R., & Birkner, E. (2018) · Molecules · doi:10.3390/molecules23123309 · Cited by 89
“has confirmed antioxidant and DNA-protective action of 5-CQA and its isomers 3-CQA and 4-CQA [155].”
Background
Metadata
- Authors
- Xu, J.-G., Hu, Q.-P., & Liu, Y.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-11-13
- Volume
- 60
- Issue
- 46
- Pages
- 11625-11630
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2018919826
- Cited by
- 368
- References
- 32
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- closed
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