The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Effective Inhibition of Skin Cancer, Tyrosinase, and Antioxidative Properties by Astaxanthin and Astaxanthin Esters from the Green Alga Haematococcus pluvialis
Abstract
Astaxanthin mono- (AXME) and diesters (AXDE) were characterized and examined for anticancer potency with total carotenoids (TC) and astaxanthin (AX) against UV-7,12-dimethylbenz(a)anthracene (DMBA)-induced skin cancer model in rat. At 200 μg/kg bw, AXDE and AXME reduced UV-DMBA-induced tumor incidences up to 96 and 88%, respectively, when compared to AX (66%) and TC (85%). UV-DMBA has been known to generate high levels of free radicals and tyrosinase enzyme, leading to characteristic symptoms of skin pigmentation and tumor initiation. Intriguingly, ~7-fold increase in tyrosinase and 10-fold decrease in antioxidant levels were normalized by AXDE and AXME as opposed to only ~1.4-2.2-fold by AX and TC, respectively. This result together with the appearance of 72 and 58 ng/mL of retinol in the serum of respective AXE-treated (AXDE + AXME) and AX-treated animals suggested that better anticancer potency of AXEs could be due to increased bioavailability.
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Cites
Ranga Rao, A., Raghunath Reddy, R. L., Baskaran, V., Sarada, R., & Ravishankar, G. A. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf101187k · Cited by 215
Self-citationUlcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis
Kamath, B. S., Srikanta, B. M., Dharmesh, S. M., Sarada, R., & Ravishankar, G. A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.042 · Cited by 162
Self-citationStewart, J. S., Lignell, Å., Pettersson, A., Elfving, E., & Soni, M. G. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.05.038 · Cited by 138
O'Connor, I., & O'Brien, N. (1998) · Journal of Dermatological Science · doi:10.1016/s0923-1811(97)00058-3 · Cited by 123
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Su, M., Bastiaens, L., Verspreet, J., & Hayes, M. (2023) · Foods · doi:10.3390/foods12203878 · Cited by 129
Metadata
- Authors
- Rao, A. R., Sindhuja, H. N., Dharmesh, S. M., Sankar, K. U., Sarada, R., & Ravishankar, G. A.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-04-16
- Volume
- 61
- Issue
- 16
- Pages
- 3842-3851
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2021134073
- Cited by
- 268
- References
- 4
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- closed
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