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Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

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Ishikawa, Minoru, Hashimoto, Yuichi·2011·Journal of Medicinal Chemistry
DOI 10.1021/jm101356p
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Abstract

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTImprovement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and SymmetryMinoru Ishikawa* and Yuichi HashimotoView Author Information Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan*Phone: +81.3.5841.7849. Fax: +81.3.5841.8495. E-mail: [email protected]Cite this: J. Med. Chem. 2011, 54, 6, 1539–1554Publication Date (Web):February 23, 2011Publication History Received19 October 2010Published online23 February 2011Published inissue 24 March 2011https://pubs.acs.org/doi/10.1021/jm101356phttps://doi.org/10.1021/jm101356preview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views24218Altmetric-Citations449LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Agonists,Hydrophobicity,Partition coefficient,Solubility,Transition temperature Get e-Alerts

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Metadata

Authors
Ishikawa, M., & Hashimoto, Y.
Venue
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Published
2011-02-23
Volume
54
Issue
6
Pages
1539-1554
ISSN
  • 0022-2623 (ISSN-L)
  • 1520-4804
DOI
10.1021/jm101356p
OpenAlex
W1999197232
Cited by
619
References
4
FWCI
20.65
Type
journal article
Language
en
Open access
green

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