The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Free Radical Scavenging by Natural Polyphenols: Atom versus Electron Transfer
Abstract
Polyphenols (synthetically modified or directly provided by human diet) scavenge free radicals by H-atom transfer and may thus decrease noxious effects due to oxidative stress. Free radical scavenging by polyphenols has been widely theoretically studied from the thermodynamic point of view whereas the kinetic point of view has been much less addressed. The present study describes kinetic-based structure-activity relationship for quercetin. This compound is very characteristic of the wide flavonoid subclass of polyphenols. H-atom transfer is a mechanism based on either atom or electron transfer. This is analyzed here by quantum chemical calculations, which support the knowledge acquired from experimental studies. The competition between the different processes is discussed in terms of the nature of the prereaction complexes, the pH, the formation of activated-deprotonated forms, and the atom- and electron-transfer efficiency. The role of the catechol moiety and the 3-OH group of quercetin as scavengers of different types of free radicals (CH3OO(•), CH3O(•), (•)OH, and (•)CH2OH) is rationalized. Identifying the exact mechanism and accurately evaluating kinetics is of fundamental importance to understand antioxidant behavior in physiological environments.
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Cites
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ABTS/PP Decolorization Assay of Antioxidant Capacity Reaction Pathways
Ilyasov, I. R., Beloborodov, V. L., Selivanova, I. A., & Terekhov, R. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031131 · Cited by 543
Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries
Bezerra, F. S., Lanzetti, M., Nesi, R. T., Nagato, A. C., Silva, C. P. E., Kennedy-Feitosa, E., Melo, A. C., Cattani-Cavalieri, I., Porto, L. C., & Valenca, S. S. (2023) · Antioxidants · doi:10.3390/antiox12030548 · Cited by 336
Reglodi, D., Renaud, J., Tamas, A., Tizabi, Y., Socías, S. B., Del-Bel, E., & Raisman-Vozari, R. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.004 · Cited by 162
Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress
Galano, A., Castañeda-Arriaga, R., Pérez-González, A., Tan, D.-X., & Reiter, R. (2016) · Molecules · doi:10.3390/molecules21111442 · Cited by 60
Metadata
- Authors
- Di Meo, F., Lemaur, V., Cornil, J., Lazzaroni, R., Duroux, J.-L., Olivier, Y., & Trouillas, P.
- Venue
- The Journal of Physical Chemistry A
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-03-05
- Volume
- 117
- Issue
- 10
- Pages
- 2082-2092
- ISSN
- 1089-5639 (ISSN-L)
- 1520-5215
- OpenAlex
- W2325469858
- Cited by
- 294
- References
- 63
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Di Meo, F., Lemaur, V., Cornil, J., Lazzaroni, R., Duroux, J.-L., Olivier, Y., & Trouillas, P. (2013). Free Radical Scavenging by Natural Polyphenols: Atom versus Electron Transfer. The Journal of Physical Chemistry A. https://doi.org/10.1021/jp3116319
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