Versatile Copolymerization of Glycolide and rac-Lactide by Dimethyl(salicylaldiminato)aluminum Compounds
Abstract
The dimethylaluminum compounds Al(CH 3 ) 2 [(O-2-{(C 6 F 5 )N═CH}-4,6-R 2 C 6 H 2 )], R = H ( 1 ) or cumyl ( 2 ), were synthesized and tested as initiators in the homo- and copolymerization of rac -lactide and glycolide. These complexes resulted active for the production of PLGA copolymers with variable microstructure. All the copolymers were fully characterized by NMR, GPC, and DSC analysis. The copolymerization reactions were performed in bulk and in solution, by varying comonomers ratio, monomer/catalyst feed ratio, temperature, reaction time, and solvent. Interestingly, by changing the reaction conditions, copolymers from random, to blocky, to diblock were obtained, demonstrating the effectiveness and versatility of such systems in modulating the copolymers microstructure and the related thermal properties.
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This family of catalysts was highly versatile and active in ROP of traditional cyclic esters (glycolide, lactide, caprolactone), large ring macrolactone, and novel thiol-functionalized lactide.
“This family of catalysts were highly versatile and active not only in the ROP of traditional cyclic esters i.e., glycolide, lactide and caprolactone [30,31], but also oflarge ring macrolactone [32,33] and ofnovel synthetized thiol-functionalized lactide [34,35].”
From Thermo-Rheological and Shape Memory Properties of Block and Random Copolymers of Lactide and ε-Caprolactone (2021) · cites this paper as [30]
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- Authors
- Meduri, A., Fuoco, T., Lamberti, M., Pellecchia, C., & Pappalardo, D.
- Affiliations
- University of Sannio (IT)
- University of Salerno (IT)
- Corresponding author
- Pappalardo, Daniela
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-01-07
- Volume
- 47
- Issue
- 2
- Pages
- 534-543
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2331584902
- Cited by
- 89
- References
- 47
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 10 · 2020: 5 · 2019: 8 · 2018: 7 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 7
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecules (publishedVersion)
- Funders
- Ministero dell'Università e della Ricerca
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Carbon dioxide utilization in catalysis
- Keywords
- glycolide, rac-lactide, PLGA copolymer, copolymerization, polymerization initiators, copolymer microstructure, block copolymers, random copolymers, diblock copolymers, thermal properties
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