Cited by 89biodegradable polymer synthesis and propertiesAdvanced Polymer Synthesis and CharacterizationCarbon dioxide utilization in catalysis

Versatile Copolymerization of Glycolide and rac-Lactide by Dimethyl(salicylaldiminato)aluminum Compounds

Meduri, Angelo, Fuoco, Tiziana, Lamberti, Marina, Pellecchia, Claudio, Pappalardo, Daniela·2014·Macromolecules

Abstract

The dimethylaluminum compounds Al(CH 3 ) 2 [(O-2-{(C 6 F 5 )N═CH}-4,6-R 2 C 6 H 2 )], R = H ( 1 ) or cumyl ( 2 ), were synthesized and tested as initiators in the homo- and copolymerization of rac -lactide and glycolide. These complexes resulted active for the production of PLGA copolymers with variable microstructure. All the copolymers were fully characterized by NMR, GPC, and DSC analysis. The copolymerization reactions were performed in bulk and in solution, by varying comonomers ratio, monomer/catalyst feed ratio, temperature, reaction time, and solvent. Interestingly, by changing the reaction conditions, copolymers from random, to blocky, to diblock were obtained, demonstrating the effectiveness and versatility of such systems in modulating the copolymers microstructure and the related thermal properties.

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Crossref · 10.1021/ma402174y

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  • This family of catalysts was highly versatile and active in ROP of traditional cyclic esters (glycolide, lactide, caprolactone), large ring macrolactone, and novel thiol-functionalized lactide.

    “This family of catalysts were highly versatile and active not only in the ROP of traditional cyclic esters i.e., glycolide, lactide and caprolactone [30,31], but also oflarge ring macrolactone [32,33] and ofnovel synthetized thiol-functionalized lactide [34,35].”

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Authors
Meduri, A., Fuoco, T., Lamberti, M., Pellecchia, C., & Pappalardo, D.
Affiliations
  • University of Sannio (IT)
  • University of Salerno (IT)
Corresponding author
Pappalardo, Daniela
Venue
Macromolecules
Published
2014-01-07
Volume
47
Issue
2
Pages
534-543
ISSN
  • 0024-9297 (ISSN-L)
  • 1520-5835
OpenAlex
W2331584902
Cited by
89
References
47
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 10 · 2020: 5 · 2019: 8 · 2018: 7 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 7
FWCI
5.05
Type
journal article
Language
en
Open access
closed
Locations
Macromolecules (publishedVersion)
Funders
Ministero dell'Università e della Ricerca
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Carbon dioxide utilization in catalysis
Keywords
glycolide, rac-lactide, PLGA copolymer, copolymerization, polymerization initiators, copolymer microstructure, block copolymers, random copolymers, diblock copolymers, thermal properties

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