The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Molecular Design and in Vitro Studies of Novel pH-Sensitive Hydrogels for the Oral Delivery of Calcitonin
Abstract
pH-sensitive hydrogels are suitable candidates for oral drug delivery of peptides due to their ability to respond to their environment. We have developed new hydrogels composed of poly(methacrylic acid) (PMAA) grafted with poly(ethylene glycol) (PEG) (P(MAA- g -EG)) which can be used as drug delivery carriers for salmon calcitonin. P(MAA- g -EG) hydrogels were prepared by free radical solution polymerization. The monomer mixture was diluted using a 50% w/w solution of ethanol and water. The percentage of monomer in solution was varied from 84% to 45% v/v. Swelling studies were conducted to investigate the effects of solvent content used during polymer preparation in the swelling behavior. The effects of dilution on the swelling behavior were not observed until the monomer mixture was diluted to approximately 50%. Salmon calcitonin was successfully incorporated and released in vitro from the system. Solutions of approximately 0.1 mg/mL of salmon calcitonin were used to load the protein into the gels at pH = 7 and constant ionic strength of 0.1 M. The loading efficiency was affected by the amount of solvent used during hydrogel preparation. In vitro release studies were performed at pH = 7 and 37 °C, while keeping an ionic strength of 0.1 M. The release behavior was found to be not very much affected by the amount of diluent used during polymer preparation. The transport mechanism was found to be relaxation controlled for all cases, and the diffusion coefficient was estimated using a heuristic Fickian/relaxational model.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Principles of Polymer Chemistry.
Huggins, M. L. (1954) · Journal of the American Chemical Society · doi:10.1021/ja01639a090 · Cited by 16,550
Principles of polymer chemistry
(1995) · Choice Reviews Online · doi:10.5860/choice.33-2140 · Cited by 15,218
Berens, A. R., & Hopfenberg, H. B. (1978) · Polymer · doi:10.1016/0032-3861(78)90269-0 · Cited by 679
Analysis of the Complexation/Decomplexation Phenomena in Graft Copolymer Networks
Lowman, A. M., & Peppas, N. A. (1997) · Macromolecules · doi:10.1021/ma970399k · Cited by 141
Self-citationControlled release by using poly(methacrylic acid-g-ethylene glycol) hydrogels
Peppas, N. A., & Klier, J. (1991) · Journal of Controlled Release · doi:10.1016/0168-3659(91)90044-e · Cited by 137
Self-citationFrom sticky stuff to sweet receptors — achievements, limits and novel approaches to bioadhesion
Lehr, C. (1996) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03190262 · Cited by 103
Molecular analysis of interpolymer complexation in graft copolymer networks
Lowman, A. M., & Peppas, N. A. (2000) · Polymer · doi:10.1016/s0032-3861(99)00159-7 · Cited by 76
Self-citationNovel Bioadhesive Complexation Networks for Oral Protein Drug Delivery
Lowman, A. M., Peppas, N. A., Morishita, M., & NAGAI, T. (1998) · ACS symposium series · doi:10.1021/bk-1998-0709.ch012 · Cited by 22
Self-citation
Cited by
Stimuli-reponsive polymers and their bioconjugates
GIL, E., & HUDSON, S. (2004) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2004.08.003 · Cited by 2,385
Hydrogels in controlled release formulations: Network design and mathematical modeling
Lin, C.-C., & Metters, A. T. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.004 · Cited by 1,768
Polymers for Drug Delivery Systems
Liechty, W. B., Kryscio, D. R., Slaughter, B. V., & Peppas, N. A. (2010) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-073009-100847 · Cited by 1,608
Self-citationPhysicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology
Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., & Zhang, J. (2000) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.2.1.9 · Cited by 1,016
Self-citationAdvances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 855
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
Homayun, B., Lin, X., & Choi, H.-J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030129 · Cited by 837
Salt-Triggered Peptide Folding and Consequent Self-Assembly into Hydrogels with Tunable Modulus
Ozbas, B., Kretsinger, J., Rajagopal, K., Schneider, J. P., & Pochan, D. J. (2004) · Macromolecules · doi:10.1021/ma0491762 · Cited by 429
Therapeutic applications of hydrogels in oral drug delivery
Sharpe, L. A., Daily, A. M., Horava, S. D., & Peppas, N. A. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.902047 · Cited by 354
Self-citationChen, J.-K., & Chang, C.-J. (2014) · Materials · doi:10.3390/ma7020805 · Cited by 193
Wang, Q., Xie, X., Zhang, X., Zhang, J., & Wang, A. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2010.01.009 · Cited by 162
Bera, A., Singh Chandel, A. K., Uday Kumar, C., & Jewrajka, S. K. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01251a · Cited by 62
Pourjavadi, A., & Barzegar, S. (2009) · Starch - Stärke · doi:10.1002/star.200800032 · Cited by 39
Metadata
- Authors
- Torres-Lugo, M., & Peppas, N. A.
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 1999-09-18
- Volume
- 32
- Issue
- 20
- Pages
- 6646-6651
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2142147016
- Cited by
- 299
- References
- 8
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
