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Cited by 332

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Endocytosis and Intracellular Trafficking as Gateways for Nanomedicine Delivery: Opportunities and Challenges

Duncan, Ruth, Richardson, Simon C. W.·2012·Molecular Pharmaceutics
DOI 10.1021/mp300293n
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Abstract

More than 40 nanomedicines are already in routine clinical use with a growing number following in preclinical and clinical development. The therapeutic objectives are often enhanced disease-specific targeting (with simultaneously reduced access to sites of toxicity) and, especially in the case of macromolecular biotech drugs, improving access to intracellular pharmacological target receptors. Successful navigation of the endocytic pathways is usually a prerequisite to achieve these goals. Thus a comprehensive understanding of endocytosis and intracellular trafficking pathways in both the target and bystander normal cell type(s) is essential to enable optimal nanomedicine design. It is becoming evident that endocytic pathways can become disregulated in disease and this, together with the potential changes induced during exposure to the nanocarrier itself, has the potential to significantly impact nanomedicine performance in terms of safety and efficacy. Here we overview the endomembrane trafficking pathways, discuss the methods used to determine and quantitate the intracellular fate of nanomedicines, and review the current status of lysosomotropic and endosomotropic delivery. Based on the lessons learned during more than 3 decades of clinical development, the need to use endocytosis-relevant clinical biomarkers to better select those patients most likely to benefit from nanomedicine therapy is also discussed.

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Metadata

Authors
Duncan, R., & Richardson, S. C. W.
Venue
Molecular Pharmaceutics
Publisher
American Chemical Society (ACS)
Published
2012-08-20
Volume
9
Issue
9
Pages
2380-2402
ISSN
  • 1543-8384 (ISSN-L)
  • 1543-8392
DOI
10.1021/mp300293n
OpenAlex
W2077850064
Cited by
332
References
9
FWCI
12.51
Type
journal article
Language
en
Open access
closed

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