The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Endocytosis and Intracellular Trafficking as Gateways for Nanomedicine Delivery: Opportunities and Challenges
Abstract
More than 40 nanomedicines are already in routine clinical use with a growing number following in preclinical and clinical development. The therapeutic objectives are often enhanced disease-specific targeting (with simultaneously reduced access to sites of toxicity) and, especially in the case of macromolecular biotech drugs, improving access to intracellular pharmacological target receptors. Successful navigation of the endocytic pathways is usually a prerequisite to achieve these goals. Thus a comprehensive understanding of endocytosis and intracellular trafficking pathways in both the target and bystander normal cell type(s) is essential to enable optimal nanomedicine design. It is becoming evident that endocytic pathways can become disregulated in disease and this, together with the potential changes induced during exposure to the nanocarrier itself, has the potential to significantly impact nanomedicine performance in terms of safety and efficacy. Here we overview the endomembrane trafficking pathways, discuss the methods used to determine and quantitate the intracellular fate of nanomedicines, and review the current status of lysosomotropic and endosomotropic delivery. Based on the lessons learned during more than 3 decades of clinical development, the need to use endocytosis-relevant clinical biomarkers to better select those patients most likely to benefit from nanomedicine therapy is also discussed.
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Cites
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Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts
Stewart, M. P., Langer, R., & Jensen, K. F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00678 · Cited by 747
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Fluorescent Polymer Nanoparticles Based on Dyes: Seeking Brighter Tools for Bioimaging
Reisch, A., & Klymchenko, A. S. (2016) · Small · doi:10.1002/smll.201503396 · Cited by 634
Ph-responsive polymer–drug conjugates: design and progress
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Metadata
- Authors
- Duncan, R., & Richardson, S. C. W.
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-08-20
- Volume
- 9
- Issue
- 9
- Pages
- 2380-2402
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W2077850064
- Cited by
- 332
- References
- 9
- FWCI
- 12.51
- Type
- journal article
- Language
- en
- Open access
- closed
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