The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Cell Uptake and in Vitro Toxicity of Magnetic Nanoparticles Suitable for Drug Delivery
Abstract
Magnetic targeting is useful for intravascular or intracavitary drug delivery, including tumor chemotherapy or intraocular antiangiogenic therapy. For all such in vivo applications, the magnetic drug carrier must be biocompatible and nontoxic. In this work, we investigated the toxic properties of magnetic nanoparticles coated with polyethylenoxide (PEO) triblock copolymers. Such coatings prevent the aggregation of magnetic nanoparticles and guarantee consistent magnetic and nonmagnetic flow properties. It was found that the PEO tail block length inversely correlates with toxicity. The nanoparticles with the shortest 0.75 kDa PEO tails were the most toxic, while particles coated with the 15 kDa PEO tail block copolymers were the least toxic. Toxicity responses of the tested prostate cancer cell lines (PC3 and C4-2), human umbilical vein endothelial cells (HUVECs), and human retinal pigment epithelial cells (HRPEs) were similar. Furthermore, all cell types took up the coated magnetic nanoparticles. It is concluded that magnetite nanoparticles coated with triblock copolymers containing PEO tail lengths of above 2 kDa are biocompatible and appropriate for in vivo application.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cell Death: The Significance of Apoptosis
Wyllie, A. H., Kerr, J. F. R., & Currie, A. R. (1980) · International Review of Cytology · doi:10.1016/s0074-7696(08)62312-8 · Cited by 7,162
Lewin, M., Carlesso, N., Tung, C.-H., Tang, X.-W., Cory, D., Scadden, D. T., & Weissleder, R. (2000) · Nature Biotechnology · doi:10.1038/74464 · Cited by 1,716
Chemical synthesis of magnetic nanoparticles
Hyeon, T. (2003) · Chemical Communications · doi:10.1039/b207789b · Cited by 1,576
Wang, Y.-X. J., Hussain, S. M., & Krestin, G. P. (2001) · European Radiology · doi:10.1007/s003300100908 · Cited by 1,381
Superparamagnetic iron oxide: pharmacokinetics and toxicity
Weissleder, R., Stark, D., Engelstad, B., Bacon, B., Compton, C., White, D., Jacobs, P., & Lewis, J. (1989) · American Journal of Roentgenology · doi:10.2214/ajr.152.1.167 · Cited by 1,045
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
Weissleder, R., Kelly, K., Sun, E. Y., Shtatland, T., & Josephson, L. (2005) · Nature Biotechnology · doi:10.1038/nbt1159 · Cited by 904
In vivo magnetic resonance imaging of transgene expression
Weissleder, R., Moore, A., Mahmood, U., Bhorade, R., Benveniste, H., Chiocca, E. A., & Basilion, J. P. (2000) · Nature Medicine · doi:10.1038/73219 · Cited by 776
Toxicity and Tissue Distribution of Magnetic Nanoparticles in Mice
Kim, J. S., Yoon, T.-J., Yu, K. N., Kim, B. G., Park, S. J., Kim, H. W., Lee, K. H., Park, S. B., Lee, J.-K., & Cho, M. H. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj027 · Cited by 633
Kohler, N., Sun, C., Wang, J., & Zhang, M. (2005) · Langmuir · doi:10.1021/la0503451 · Cited by 579
Vascular Targeted Nanoparticles for Imaging and Treatment of Brain Tumors
Reddy, G. R., Bhojani, M. S., McConville, P., Moody, J., Moffat, B. A., Hall, D. E., Kim, G., Koo, Y.-E. L., Woolliscroft, M. J., Sugai, J. V., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0946 · Cited by 491
Cited by
Nanoparticles as drug delivery systems
Wilczewska, A. Z., Niemirowicz, K., Markiewicz, K. H., & Car, H. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70901-5 · Cited by 1,445
Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
Singh, N., Jenkins, G. J. S., Asadi, R., & Doak, S. H. (2010) · Nano Reviews · doi:10.3402/nano.v1i0.5358 · Cited by 1,112
Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy
Krishnan, K. M. (2010) · IEEE Transactions on Magnetics · doi:10.1109/tmag.2010.2046907 · Cited by 819
Applications and potential toxicity of magnetic iron oxide nanoparticles
Liu, G., Gao, J., Ai, H., & Chen, X. (2013) · Small · doi:10.1002/smll.201201531 · Cited by 570
Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review
Malhotra, N., Lee, J.-S., Liman, R. A. D., Ruallo, J. M. S., Villaflores, O. B., Ger, T.-R., & Hsiao, C.-D. (2020) · Molecules · doi:10.3390/molecules25143159 · Cited by 470
Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-Carriers
Jin, L., Zeng, X., Liu, M., Deng, Y., & He, N. (2014) · Theranostics · doi:10.7150/thno.6914 · Cited by 388
Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
Jasmin, Souza, G. T., Andrade Louzada, R., Rosado-de-Castro, P. H., Mendez-Otero, R., & Carvalho, A. C. C. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s126530 · Cited by 78
Small versus Large Iron Oxide Magnetic Nanoparticles: Hyperthermia and Cell Uptake Properties
Iacovita, C., Florea, A., Dudric, R., Pall, E., Moldovan, A., Tetean, R., Stiufiuc, R., & Lucaciu, C. (2016) · Molecules · doi:10.3390/molecules21101357 · Cited by 57
Recent Advances in the Development of Magnetic Nanoparticles for Biomedical Applications
Monteserín, M., Larumbe, S., Martínez, A. V., Burgui, S., & Francisco Martín, L. (2021) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2021.19062 · Cited by 27
Schizophrenia, Curcumin and Minimizing Side Effects of Antipsychotic Drugs: Possible Mechanisms
Rabiee, R., Hosseini Hooshiar, S., Ghaderi, A., & Jafarnejad, S. (2023) · Neurochemical Research · doi:10.1007/s11064-022-03798-4 · Cited by 11
Metadata
- Authors
- Häfeli, U. O., Riffle, J. S., Harris-Shekhawat, L., Carmichael-Baranauskas, A., Mark, F., Dailey, J. P., & Bardenstein, D.
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-05-26
- Volume
- 6
- Issue
- 5
- Pages
- 1417-1428
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W1990894546
- Cited by
- 277
- References
- 57
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
