The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Ultrahigh Sensitivity Carbon Nanotube Agents for Photoacoustic Molecular Imaging in Living Mice
Open accessAbstract
Photoacoustic imaging is an emerging modality that overcomes to a great extent the resolution and depth limitations of optical imaging while maintaining relatively high-contrast. However, since many diseases will not manifest an endogenous photoacoustic contrast, it is essential to develop exogenous photoacoustic contrast agents that can target diseased tissue(s). Here we present a novel photoacoustic contrast agent, Indocyanine Green dye-enhanced single walled carbon nanotube (SWNT-ICG). We conjugated this contrast agent with cyclic Arg-Gly-Asp (RGD) peptides to molecularly target the alpha(v)beta(3) integrins, which are associated with tumor angiogenesis. Intravenous administration of this tumor-targeted contrast agent to tumor-bearing mice showed significantly higher photoacoustic signal in the tumor than in mice injected with the untargeted contrast agent. The new contrast agent gave a markedly 300 times higher photoacoustic contrast in living tissues than previously reported SWNTs, leading to subnanomolar sensitivities. Finally, we show that the new contrast agent can detect approximately 20 times fewer cancer cells than previously reported SWNTs.
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Cites
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Self-citationPhotoacoustic Imaging of Mesenchymal Stem Cells in Living Mice via Silica-Coated Gold Nanorods
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Indocyanine Green J Aggregates in Polymersomes for Near-Infrared Photoacoustic Imaging
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Metadata
- Authors
- Zerda, A. D. L., Liu, Z., Bodapati, S., Teed, R., Vaithilingam, S., Khuri-Yakub, B. T., Chen, X., Dai, H., & Gambhir, S. S.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-05-25
- Volume
- 10
- Issue
- 6
- Pages
- 2168-2172
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2096952219
- Cited by
- 396
- References
- 14
- FWCI
- 17.48
- Type
- journal article
- Language
- en
- Open access
- green
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