The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Nanostraws for Direct Fluidic Intracellular Access
Abstract
Nanomaterials are promising candidates to improve the delivery efficiency and control of active agents such as DNA or drugs directly into cells. Here we demonstrate cell-culture platforms of nanotemplated "nanostraws" that pierce the cell membrane, providing a permanent fluidic pipeline into the cell for direct cytosolic access. Conventional polymeric track-etch cell culture membranes are alumina coated and etched to produce fields of nanostraws with controllable diameter, thickness, and height. Small molecules and ions were successfully transported into the cytosol with 40 and 70% efficiency, respectively, while GFP plasmids were successfully delivered and expressed. These platforms open the way for active, reproducible delivery of a wide variety of species into cells without endocytosis.
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Cites
Molecular characterization of mitochondrial apoptosis-inducing factor
Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060
Biomolecular gradients in cell culture systems
Keenan, T. M., & Folch, A. (2008) · Lab Chip · doi:10.1039/b711887b · Cited by 596
Biodegradable nanoparticles for cytosolic delivery of therapeutics
VASIR, J., & LABHASETWAR, V (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.06.003 · Cited by 526
Zeck, G., & Fromherz, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181348698 · Cited by 290
Multifunctional carbon-nanotube cellular endoscopes.
Singhal, R., Orynbayeva, Z., Kalyana Sundaram, R. V., Niu, J. J., Bhattacharyya, S., Vitol, E. A., Schrlau, M. G., Papazoglou, E. S., Friedman, G., & Gogotsi, Y. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.241 · Cited by 241
Cited by
In vitro and ex vivo strategies for intracellular delivery
Stewart, M. P., Sharei, A., Ding, X., Sahay, G., Langer, R., & Jensen, K. F. (2016) · Nature · doi:10.1038/nature19764 · Cited by 885
Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts
Stewart, M. P., Langer, R., & Jensen, K. F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00678 · Cited by 747
Three-dimensional nano-biointerface as a new platform for guiding cell fate
Liu, X., & Wang, S. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60419e · Cited by 275
CMOS nanoelectrode array for all-electrical intracellular electrophysiological imaging
Abbott, J., Ye, T., Qin, L., Jorgolli, M., Gertner, R. S., Ham, D., & Park, H. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.3 · Cited by 266
Nanotechnology: emerging tools for biology and medicine
Wong, I. Y., Bhatia, S. N., & Toner, M. (2013) · Genes & Development · doi:10.1101/gad.226837.113 · Cited by 132
Metadata
- Authors
- VanDersarl, J. J., Xu, A. M., & Melosh, N. A.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-12-20
- Volume
- 12
- Issue
- 8
- Pages
- 3881-3886
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2005933611
- Cited by
- 223
- References
- 5
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
