The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
A DNA Nanostructure Platform for Directed Assembly of Synthetic Vaccines
Open accessAbstract
Safe and effective vaccines offer the best intervention for disease control. One strategy to maximize vaccine immunogenicity without compromising safety is to rationally design molecular complexes that mimic the natural structure of immunogenic microbes but without the disease-causing components. Here we use highly programmable DNA nanostructures as platforms to assemble a model antigen and CpG adjuvants together into nanoscale complexes with precise control of the valency and spatial arrangement of each element. Our results from immunized mice show that compared to a mixture of antigen and CpG molecules, the assembled antigen-adjuvant-DNA complexes induce strong and long-lasting antibody responses against the antigen without stimulating a reaction to the DNA nanostructure itself. This result demonstrates the potential of DNA nanostructures to serve as general platforms for the rational design and construction of a variety of vaccines.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Self-assembly of DNA into nanoscale three-dimensional shapes
Douglas, S. M., Dietz, H., Liedl, T., Högberg, B., Graf, F., & Shih, W. M. (2009) · Nature · doi:10.1038/nature08016 · Cited by 2,571
Nucleic acid junctions and lattices
Seeman, N. C. (1982) · Journal of Theoretical Biology · doi:10.1016/0022-5193(82)90002-9 · Cited by 2,497
A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
Douglas, S. M., Bachelet, I., & Church, G. M. (2012) · Science · doi:10.1126/science.1214081 · Cited by 2,180
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
Bachmann, M. F., & Jennings, G. T. (2010) · Nature Reviews Immunology · doi:10.1038/nri2868 · Cited by 2,106
DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires
Yan, H., Park, S. H., Finkelstein, G., Reif, J. H., & LaBean, T. H. (2003) · Science · doi:10.1126/science.1089389 · Cited by 1,762
Self-citationFolding DNA into Twisted and Curved Nanoscale Shapes
Dietz, H., Douglas, S. M., & Shih, W. M. (2009) · Science · doi:10.1126/science.1174251 · Cited by 1,335
Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra
He, Y., Ye, T., Su, M., Zhang, C., Ribbe, A. E., Jiang, W., & Mao, C. (2008) · Nature · doi:10.1038/nature06597 · Cited by 1,304
DNA Origami with Complex Curvatures in Three-Dimensional Space
Han, D., Pal, S., Nangreave, J., Deng, Z., Liu, Y., & Yan, H. (2011) · Science · doi:10.1126/science.1202998 · Cited by 1,214
Self-citationRapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication
Goodman, R. P., Schaap, I. A. T., Tardin, C. F., Erben, C. M., Berry, R. M., Schmidt, C. F., & Turberfield, A. J. (2005) · Science · doi:10.1126/science.1120367 · Cited by 1,171
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
Lee, H., Lytton-Jean, A. K. R., Chen, Y., Love, K. T., Park, A. I., Karagiannis, E. D., Sehgal, A., Querbes, W., Zurenko, C. S., Jayaraman, M., et al. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.73 · Cited by 1,169
Immunotherapeutic uses of CpG oligodeoxynucleotides
Klinman, D. M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1329 · Cited by 1,012
A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron
Shih, W. M., Quispe, J. D., & Joyce, G. F. (2004) · Nature · doi:10.1038/nature02307 · Cited by 989
Assembling Materials with DNA as the Guide
Aldaye, F. A., Palmer, A. L., & Sleiman, H. F. (2008) · Science · doi:10.1126/science.1154533 · Cited by 976
Programming the magnitude and persistence of antibody responses with innate immunity
Kasturi, S. P., Skountzou, I., Albrecht, R. A., Koutsonanos, D., Hua, T., Nakaya, H. I., Ravindran, R., Stewart, S., Alam, M., Kwissa, M., et al. (2011) · Nature · doi:10.1038/nature09737 · Cited by 975
Li, J., Pei, H., Zhu, B., Liang, L., Wei, M., He, Y., Chen, N., Li, D., Huang, Q., & Fan, C. (2011) · ACS Nano · doi:10.1021/nn202774x · Cited by 748
DNA Cage Delivery to Mammalian Cells
Walsh, A. S., Yin, H., Erben, C. M., Wood, M. J. A., & Turberfield, A. J. (2011) · ACS Nano · doi:10.1021/nn2005574 · Cited by 599
Virus-like particles as immunogens
Noad, R., & Roy, P. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(03)00208-7 · Cited by 581
Nanotechnology in vaccine delivery
Peek, L. J., Middaugh, C. R., & Berkland, C. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.05.017 · Cited by 562
Cellular Immunostimulation by CpG-Sequence-Coated DNA Origami Structures
Schüller, V. J., Heidegger, S., Sandholzer, N., Nickels, P. C., Suhartha, N. A., Endres, S., Bourquin, C., & Liedl, T. (2011) · ACS Nano · doi:10.1021/nn203161y · Cited by 495
CpG motifs as immune adjuvants
Klinman, D. M., Barnhart, K. M., & Conover, J. (1999) · Vaccine · doi:10.1016/s0264-410x(98)00151-0 · Cited by 308
Conformational flexibility facilitates self-assembly of complex DNA nanostructures
Zhang, C., Su, M., He, Y., Zhao, X., Fang, P.-A., Ribbe, A. E., Jiang, W., & Mao, C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803841105 · Cited by 288
An autonomous DNA nanomachine maps spatiotemporal pH changes in a multicellular living organism
Surana, S., Bhat, J. M., Koushika, S. P., & Krishnan, Y. (2011) · Nature Communications · doi:10.1038/ncomms1340 · Cited by 254
A DNA-Reacting Factor in Serum of a Patient with Lupus Erythematosus Diffusus.
Ceppellini, R., Polli, E., & Celada, F. (1957) · Experimental Biology and Medicine · doi:10.3181/00379727-96-23544 · Cited by 249
Mohri, K., Nishikawa, M., Takahashi, N., Shiomi, T., Matsuoka, N., Ogawa, K., Endo, M., Hidaka, K., Sugiyama, H., Takahashi, Y., et al. (2012) · ACS Nano · doi:10.1021/nn300727j · Cited by 179
Innovative strategies for co-delivering antigens and CpG oligonucleotides
Krishnamachari, Y., & Salem, A. K. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.12.013 · Cited by 160
Auyeung, E., Cutler, J. I., Macfarlane, R. J., Jones, M. R., Wu, J., Liu, G., Zhang, K., Osberg, K. D., & Mirkin, C. A. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2011.222 · Cited by 158
DNA Self-assembly for Nanomedicine
Chhabra, R., Sharma, J., Liu, Y., Rinker, S. D., & Yan, H. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.03.005 · Cited by 145
Self-citationRattanakiat, S., Nishikawa, M., Funabashi, H., Luo, D., & Takakura, Y. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.053 · Cited by 121
Enhanced immunostimulatory activity of oligodeoxynucleotides by Y‐shape formation
Nishikawa, M., Matono, M., Rattanakiat, S., Matsuoka, N., & Takakura, Y. (2008) · Immunology · doi:10.1111/j.1365-2567.2007.02762.x · Cited by 104
DNA‐Directed Three‐Dimensional Protein Organization
Zhang, C., Tian, C., Guo, F., Liu, Z., Jiang, W., & Mao, C. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201108710 · Cited by 101
Human erythropoietin dimers with markedly enhanced in vivo activity
Sytkowski, A. J., Dotimas, E., Davis, K. L., Feldman, L., & Siekman, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1184 · Cited by 58
Exterior modification of a DNA tetrahedron
Zhang, C., Su, M., He, Y., Leng, Y., Ribbe, A. E., Wang, G., Jiang, W., & Mao, C. (2010) · Chemical Communications · doi:10.1039/c0cc02363a · Cited by 46
Cited by
DNA Nanotechnology-Enabled Drug Delivery Systems
Hu, Q., Li, H., Wang, L., Gu, H., & Fan, C. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00663 · Cited by 1,118
Wang, F., Lu, C.-H., & Willner, I. (2014) · Chemical Reviews · doi:10.1021/cr400354z · Cited by 649
Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy
Meng, H.-M., Liu, H., Kuai, H., Peng, R., Mo, L., & Zhang, X.-B. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00645g · Cited by 608
DNA nanotechnology from the test tube to the cell
Chen, Y.-J., Groves, B., Muscat, R. A., & Seelig, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.195 · Cited by 594
Smart Drug Delivery Nanocarriers with Self‐Assembled DNA Nanostructures
Li, J., Fan, C., Pei, H., Shi, J., & Huang, Q. (2013) · Advanced Materials · doi:10.1002/adma.201300875 · Cited by 441
Metadata
- Authors
- Liu, X., Xu, Y., Yu, T., Clifford, C., Liu, Y., Yan, H., & Chang, Y.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-07-06
- Volume
- 12
- Issue
- 8
- Pages
- 4254-4259
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2091691458
- Cited by
- 289
- References
- 32
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
